Results 51 to 60 of about 1,470,634 (309)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

А. Chekhov in the works of Zhang Jie

RUDN Journal of Studies in Literature and Journalism
The purpose of this paper is to examine the genesis of the work of Zhang Jie, a major Chinese prose writer of the second half of the 20th and early 21st century.
Vladimir A. Meskin, Huizhen Zhang
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Adaptive Translation Strategies for Culture-Loaded Terms in Chronicle of a Blood Merchant: A Three-Dimensional Eco-Translatological Analysis

Darnioji daugiakalbystė
In the context of globalization, the effective transmission of culture through translation has become a pressing concern, particularly in literary works where culture-loaded terms present significant challenges.
Hou Xinyu, Zou Deyan, Zhang Shuhan
doaj   +1 more source

Linguoesthetic and idiodiscursive dimensions of artistic modelling

Russian Journal of Linguistics
The study addresses the issue of the linguistic analysis of artistic discourse in the aesthetic projection of idiodiscursive language modelling, where artistic discourse is understood as a particular aesthetic and ethno-cultural worldview formed through ...
Alexander V. Ignatenko
doaj   +1 more source

Juri Lotman’s autocommunication model and Roland Barthes’s representations of Self and Other

Sign Systems Studies, 2014
This paper discusses Juri Lotman’s concept of autocommunication and explores its applicability by referring to Roland Barthes’s representations of Self and Other.
Lei Han
doaj   +1 more source

A Dream of a Stone: The Ethics of De-anthropocentrism

Open Philosophy, 2020
De-anthropocentrism is the leitmotif of philosophy in the twenty-first century, encouraging diverse and competing thoughts as to how this goal may be achieved.
Wu Tsaiyi
doaj   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Barriers to the successful exploitation of ERP systems in Chinese state-owned enterprises

, 2010
Adopting a systems perspective, the research presented in this paper aims at identifying, assessing and discussing potential cultural, organisational and system barriers to the successful exploitation of Enterprise Resource Planning (ERP) systems in the ...
Nunes, J.M.B., Peng, G.C.
core   +1 more source