Results 31 to 40 of about 4,760,404 (253)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Chinese Expert Consensus on Community-based Cancer-related Fatigue Management (2025 Edition) [PDF]

Zhongguo quanke yixue
Cancer related fatigue (CRF) represents one of the most prevalent symptoms among cancer survivors, significantly impacting their quality of life.
Community Rehabilitation Working Committee of Chinese Rehabilitation Medicine Association
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Chinese medicine in Australia [PDF]

, 2016
Objectives: Chinese medicine is a complex domain of theoretical and practical approaches that is being increasingly put under the research spotlight.
Moore, A, Bensoussan, Alan (R7273), Komesaroff, PA, Komesaroff, Paul A., Alan Bensoussan, Xu, Hong, O'Brien, Kylie A. (R14413), Kylie O'Brien, Amber Moore, O'Brien, K, Bensoussan, Alan, Hong Xu, Bensoussan, A, Moore, Amber, O'brien, Kylie, Paul A. Komesaroff   +15 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Chinese Expert Consensus on Constipation Screening and Assessment for Community Cancer Patients (2025 Edition) [PDF]

Zhongguo quanke yixue
Constipation is a common complication in cancer patients, with an incidence rate ranging from 30% to 90%. It is particularly prevalent among those using opioids and patients with advanced cancer.
Community Rehabilitation Working Committee of Chinese Rehabilitation Medicine Association
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Expert Consensus on the Application of Virtual Reality Technology in Home-based Rehabilitation for Cancer-related Insomnia (2025 Edition) [PDF]

Zhongguo quanke yixue
To thoroughly implement the concept of whole-cycle rehabilitation and further standardize the application and management of virtual reality (VR) technology in home-based rehabilitation for patients with cancer-related insomnia (CRI), the Community ...
Community Rehabilitation Working Committee of Chinese Rehabilitation Medicine Association
doaj   +1 more source

Expert Consensus on Integrated Traditional Chinese and Western Medicine Management for Chronic Obstructive Pulmonary Disease (2023 Edition) [PDF]

, 2023
Chronic obstructive pulmonary disease (COPD) is one of the major chronic disease seriously affecting the health of Chinese residents. There are national and international guidelines and consensus on the diagnosis, treatment and management of COPD ...
Expert Consensus Writing Group of Integrated Traditional Chinese and Western Medicine Management for Chronic Obstructive Pulmonary Disease
core   +2 more sources