Results 51 to 60 of about 4,760,404 (253)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Chinese Diabetes Behavior and Lifestyle Intervention Guidelines (2024) [PDF]

Zhongguo quanke yixue
Behavior and lifestyle interventions (BLIs) can reduce blood glucose and blood pressure, regulate blood lipids, control obesity, reduce cardiovas cular events and are a first-line treatment for chronic diseases such as diabetes mellitus.
Diabetes Prevention and Control Committee of Chinese Preventive Medicine Association
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

(Brief discussion on the differences of Chinese Medicine education in universities between Australia and China)

, 2018
Australia,with an early start of Chinese Medicine education,is one of the few western countries holding degree courses for Chinese Medicine in universities.
Bensoussan, Alan (R7273), Zhu, Xiaoshu (R8905), Wang, Shanshan, Zhang, Danying, Zhang, Liping, Zhang, Yong   +5 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Chinese Expert Consensus on the Diagnosis and Treatment of Diabetes Comorbid with Depression [PDF]

Zhongguo quanke yixue
The comorbidity of diabetes and depression is relatively common in clinical practice,with a significant bidirectional association between the two conditions.
Psychosomatic Endocrinology Coordination Group of the Psychosomatic Medicine Society of the Chinese Medical Association, Diabetes Prevention and Control Committee of Chinese Preventive Medicine Association
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Expert recommendations on the clinical application of radiofrequency ablation for the treatment of hemorrhoids

结直肠肛门外科
There are various treatment options for hemorrhoids, and the choice of treatment should be based on the patient’s condition, acceptance, and treatment expectations in clinical practice.
Anorectal Branch of the China Association of Chinese Medicine
doaj   +1 more source

Expert consensus on the management of risk factors for benign prostatic hyperplasia (2025 edition) [PDF]

Yixue xinzhi zazhi
Benign prostatic hyperplasia (BPH) is a common urological disease in middle-aged and elderly men. Its incidence increases continuously with age, which significantly affects patients' quality of life and may even be life-threatening.
Specialty Society of Urinary System Aging-related Diseases Prevention and Treatment, Chinese Aging Well Association, Evidence-based Preventive Medicine Professional Committee, Chinese Preventive Medicine Association, Evidence-based Urology Group, Evidence-based Medicine Professional Committee, Chinese Medical Doctor Association   +6 more
doaj   +1 more source