Results 21 to 30 of about 1,449,836 (311)

Characterization and Mechanism Prediction of Active Components in Fuganlin Oral Liquid for Respiratory Tract Infections Using UPLC–Q-TOF–MS and Network Pharmacology

open access: yesJournal of Analytical Methods in Chemistry
Fuganlin oral liquid (FOL) has been clinically employed for the treatment of pediatric qi deficiency colds, manifesting symptoms such as fever, cough, asthma, and sore throat.
Mengyue Zhang   +7 more
doaj   +1 more source

Diagnostic Ion-Guided Isolation and Characterization of Trace Periplocin-Derived Cardenolide Metabolites from Rat Urine

open access: yesMolecules
Cardiac glycosides from Periplocae Cortex are bioactive constituents, but isolating and structurally confirming their trace in vivo metabolites remains challenging because authentic standards are often unavailable.
Peng Zhao   +9 more
doaj   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

open access: yesAdvanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen   +15 more
wiley   +1 more source

Quantitative Analysis of Flavonols and Their Glycosides and Gastrointestinal Transformation of Flavonol Glycosides in Yinxing Mihuan Oral Solution

open access: yesJournal of Analytical Methods in Chemistry
Yinxing Mihuan Oral Solution (YMOS) is extensively utilized in the clinical treatment of cardiovascular and cerebrovascular diseases (CCVDs), with flavonols and their glycosides identified as the primary active ingredients.
Yun Lyu   +6 more
doaj   +1 more source

Comparative pharmacokinetics of periplocin and its four key metabolites in rats after oral administration of periplocin and cardiac glycoside extract from Cortex Periplocae

open access: yesFrontiers in Pharmacology
IntroductionCortex Periplocae has been demonstrated to possess a variety of pharmacological effects, particularly in the treatment of chronic heart failure, attributed largely to its cardiac glycosides particularly periplocin.MethodsIn order to gain a ...
Peng Zhao   +7 more
doaj   +1 more source

Modern Confucianism and Chinese Theories of Modernization [PDF]

open access: yesPhilosophy Compass, 2015
Abstract The Confucian revival, which manifests itself in the modern Confucian current, belongs to the most influential and important streams of thought in contemporary Chinese philosophy and represents a crucial part of the new prevailing ideologies in P. R. China.
openaire   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

open access: yesAdvanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao   +10 more
wiley   +1 more source

Zi Shen Wan Fang repaired blood–brain barrier integrity in diabetic cognitive impairment mice via preventing cerebrovascular cells senescence

open access: yesChinese Medicine
Background Blood–brain barrier (BBB) integrity disruption is a key pathological link of diabetes-induced cognitive impairment (DCI), but the detailed mechanism of how the diabetic environment induces BBB integrity disruption is not fully understood.
Qingsheng Yin   +7 more
doaj   +1 more source

The Pharmacokinetics, Bioavailability, and Excretion Studies of α-Cyperone in Rats by UHPLC-QQQ-MS/MS

open access: yesMolecules
α-Cyperone (C15H22O), a critical bioactive sesquiterpene, serves as a representative chemical compound of Cyperi Rhizoma—a classical functional food. To investigate the pharmacokinetic characteristics of α-cyperone, a quantified method was developed in ...
Ye Shang   +11 more
doaj   +1 more source

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