Results 21 to 30 of about 1,539,179 (304)

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Quantitative Analysis of Flavonols and Their Glycosides and Gastrointestinal Transformation of Flavonol Glycosides in Yinxing Mihuan Oral Solution

Journal of Analytical Methods in Chemistry
Yinxing Mihuan Oral Solution (YMOS) is extensively utilized in the clinical treatment of cardiovascular and cerebrovascular diseases (CCVDs), with flavonols and their glycosides identified as the primary active ingredients.
Yun Lyu, Wenqian Cheng, Kejing Niu, Shaoqing He, Lulu Ma, Jing Yang, Huijuan Yu   +6 more
doaj   +1 more source

Comparative pharmacokinetics of periplocin and its four key metabolites in rats after oral administration of periplocin and cardiac glycoside extract from Cortex Periplocae

Frontiers in Pharmacology
IntroductionCortex Periplocae has been demonstrated to possess a variety of pharmacological effects, particularly in the treatment of chronic heart failure, attributed largely to its cardiac glycosides particularly periplocin.MethodsIn order to gain a ...
Peng Zhao, Fanjiao Zuo, Caixia Li, Yingjing Zhao, Yanjin Li, Haoran Wu, Yameng Zhu, Jun He   +7 more
doaj   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

Zi Shen Wan Fang repaired blood–brain barrier integrity in diabetic cognitive impairment mice via preventing cerebrovascular cells senescence

Chinese Medicine
Background Blood–brain barrier (BBB) integrity disruption is a key pathological link of diabetes-induced cognitive impairment (DCI), but the detailed mechanism of how the diabetic environment induces BBB integrity disruption is not fully understood.
Qingsheng Yin, Genhui Yang, Runtao Su, Jie Bu, Ying Li, Han Zhang, Yanjun Zhang, Pengwei Zhuang   +7 more
doaj   +1 more source

The Pharmacokinetics, Bioavailability, and Excretion Studies of α-Cyperone in Rats by UHPLC-QQQ-MS/MS

Molecules
α-Cyperone (C15H22O), a critical bioactive sesquiterpene, serves as a representative chemical compound of Cyperi Rhizoma—a classical functional food. To investigate the pharmacokinetic characteristics of α-cyperone, a quantified method was developed in ...
Ye Shang, Yameng Zhu, Kaili Zhang, Zijing Zhang, Huining Geng, Xueyu Liu, Wenwen Li, Lu Chen, Caixia Li, Yang Liu, Huizi Ouyang, Jun He   +11 more
doaj   +1 more source

Chinese Modernization in Comparative Perspective

, 2015
China's rise has become subject to fierce academic debates about the nature and possible consequences of this growth. The phenomenon of the Chinese modernization was also studied from the angle of the theories of modernization.
Andrey Vladimirovich Vinogradov
core   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Complete chloroplast genomes of four Triumfetta species obtained from herbarium specimens: comparative analysis and identification of a synapomorphic inversion

Scientific Reports
The genus Triumfetta L. (Malvaceae) comprises about 177 species, several of which are of medicinal importance. However, genomic resources for this genus remain limited, with only ten chloroplast (cp.) genomes published to date.
Rushan Yan, Abdullah, Abdul Sammad, Hui Li, Mingzhuo Fu, Ying Cui, Parviz Heidari, Xiaoxuan Tian   +7 more
doaj   +1 more source

Study on the National Conditions of Modernization with Chinese Characteristics [PDF]

This is an open access book. Based on the analysis of China’s basic national conditions and development trends, this book begins with a general introduction to the study of “modernization with Chinese characteristics,” and then discusses the ...
Hu, Angang, Xie, Yize, Zhou, Shaojie
core   +1 more source