Results 21 to 30 of about 15,143 (308)

Zi Shen Wan Fang repaired blood–brain barrier integrity in diabetic cognitive impairment mice via preventing cerebrovascular cells senescence

Chinese Medicine
Background Blood–brain barrier (BBB) integrity disruption is a key pathological link of diabetes-induced cognitive impairment (DCI), but the detailed mechanism of how the diabetic environment induces BBB integrity disruption is not fully understood.
Qingsheng Yin, Genhui Yang, Runtao Su, Jie Bu, Ying Li, Han Zhang, Yanjun Zhang, Pengwei Zhuang   +7 more
doaj   +1 more source

Simultaneous Quantification of Multiple Analytes in Rat Plasma by UHPLC–MS/MS Following Oral Administration of Gastrodiae Rhizoma Extract for Pharmacokinetic Evaluation

Molecules
Gastrodiae Rhizoma (GR) is known to have a medicinal and food-based homology. It is used to treat infantile convulsion, epilepsy, spasm, tetanus, and vertigo.
Lu Chen, Yameng Zhu, Huizi Ouyang, Xiwei Wu, Wenhan Lin, Kaili Zhang, Jun He   +6 more
doaj   +1 more source

Chinese Modernization in Comparative Perspective

, 2015
China's rise has become subject to fierce academic debates about the nature and possible consequences of this growth. The phenomenon of the Chinese modernization was also studied from the angle of the theories of modernization.
Andrey Vladimirovich Vinogradov
core   +1 more source

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Protective effect and mechanism of Perilla frutescens (L.) Britton on acute liver injury via an integrated strategy of pharmacodynamics, liver metabonomics and lipidomics, and network pharmacology

Journal of Functional Foods
This study first compared the protective effects of different parts of Perilla frutescens (L.) Britton leaves (PFo), stems (PCa), and seeds (PFr) on LPS/ D-GalN-induced acute liver injury (ALI) in rats, to screen the most effective parts.
Yameng Zhu, Yuqi Fan, Lu Chen, Ye Shang, Zhoujing Feng, Linchang Fan, Huizi Ouyang, Jun He   +7 more
doaj   +1 more source

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton

Advanced Science, EarlyView.
Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang, Jie Dai, Ting Zhao, Shengjun Zhao, Hongyu Wu, Jiaying Pan, Yupeng Hao, Ke Nie, Li Yu, Yumeng Zhu, Xiangyi Zhao, Kai Huang, Mengke Zhang, Yongyan Zhao, Yaping Jiang, Siyuan Wang, Yiling Pan, Yubing Chen, Yilai Lin, Wanghong Shi, Yayuan Deng, Jin Han, Jie Li, Xuan Long, Junbin Wang, Zhiyuan Zhang, Zegang Han, Zhanfeng Si, Lei Ju, Jun Li, Tianzhen Zhang, Ji Zhou, Xueying Guan   +32 more
wiley   +1 more source

Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity

Journal of Pharmaceutical Analysis
Plant-derived nanovesicles have gained attention given their similarity to mammalian exosomes and advantages such as low cost, sustainability, and tissue targeting. Thus, they hold promise for disease treatment and drug delivery.
Shengjie Huang, Min Zhang, Xiaoge Li, Jierong Pei, Zhirong Zhou, Peng Lei, Meng Wang, Peng Zhang, Heshui Yu, Guanwei Fan, Lifeng Han, Haiyang Yu, Yuefei Wang, Miaomiao Jiang   +13 more
doaj   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Development and validation of a UHPLC-QqQ-MS/MS method for simultaneous determination of fifteen major components from Oroxyli seed extract in rat plasma and its application in the pharmacokinetic study

Frontiers in Pharmacology
For this investigation, a UHPLC-QqQ-MS/MS method was developed for the simultaneous determination of 15 components (chrysin, chrysin-7-O-β-D-glucuronide, hispidulin, wogonoside, quercetin, quercetin-7-O-β-D-glucoside, baicalin, baicalein, acacetin ...
Zhenguo Lv, Zhenguo Lv, Kaili Zhang, Zijing Zhang, Jinyue Ma, Wenwen Li, Lu Chen, Wenhan Lin, Yameng Zhu, Minglei Ge, Huizi Ouyang, Huizi Ouyang, Jun He   +12 more
doaj   +1 more source

How Modern was Chinese Modernity?

International Journal for History, Culture and Modernity, 2014
“Modernity” continues to be a useful historiographical tool, however, it is tension-laden both theoretically and empirically. Conceptually, “modernity” can denote either a quality (“modern-ness”) or a condition referring to a specific period in history.
openaire   +1 more source