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Network Pharmacology of Natural Products from Computational Prediction to Experimental Validation [PDF]

Biomedicines
Natural products are important sources of bioactive compounds, but their complex chemical composition and multi-target effects make their mechanisms difficult to investigate using conventional approaches.
Emmanuelle Usun Stephen, Khai-Lin Hew, Chze-Yin Tan, Yeun-Mun Choo   +3 more
doaj   +2 more sources

Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment

Frontiers in Pharmacology, 2019
The research field of systems biology has greatly advanced and, as a result, the concept of network pharmacology has been developed. This advancement, in turn, has shifted the paradigm from a “one-target, one-drug” mode to a “network-target, multiple ...
Runzhi Zhang, Xue Zhu, Hong Bai, Kang Ning   +3 more
doaj   +3 more sources

The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology

Biomolecules, 2019
Natural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods to decipher the potential mechanisms of THM.
Won-Yung Lee, Choong-Yeol Lee, Youn-Sub Kim, Chang-Eop Kim   +3 more
doaj   +3 more sources

Network Pharmacology Approach for Medicinal Plants: Review and Assessment

Pharmaceuticals, 2022
Natural products have played a critical role in medicine due to their ability to bind and modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive scaffolds for the treatment of multiple disorders.
Fatima Noor, Muhammad Tahir ul Qamar, Usman Ali Ashfaq, Aqel Albutti, Ameen S. S. Alwashmi, Mohammad Abdullah Aljasir   +5 more
doaj   +3 more sources

Research trends and hotspots of neurodegenerative diseases employing network pharmacology: A bibliometric analysis

Frontiers in Pharmacology, 2023
Background: Employing network pharmacology in neurodegenerative diseases (NDs) has been extensively studied recently. However, no comprehensive study has conducted on this subject employing bibliometrics so far.
Jie Zhu, Qingchun Liang, Siyi He, Chen Wang, Xiafei Lin, Duozhi Wu, Guanwen Lin, Zhihua Wang   +7 more
doaj   +1 more source

Progress and Prospects of Research Ideas and Methods in the Network Pharmacology of Traditional Chinese Medicine

Journal of Pharmacy & Pharmaceutical Sciences, 2022
In recent years, the emerging network pharmacology has been extensively applied to the field of traditional Chinese medicine and has made great contributions to the modernization of TCM.
Zhongzhu Yuan, Yingying Pan , Tian Leng, Yu Chu, Haojie Zhang, Jingru Ma, Xiaoju Ma   +6 more
doaj   +1 more source

INPUT: An intelligent network pharmacology platform unique for traditional Chinese medicine

Computational and Structural Biotechnology Journal, 2022
The application of network pharmacology has greatly promoted the scientific interpretation of disease treatment mechanism of traditional Chinese medicine (TCM).
Xianhai Li, Qiang Tang, Fanbo Meng, Pufeng Du, Wei Chen   +4 more
doaj   +1 more source

Network pharmacology: a bright guiding light on the way to explore the personalized precise medication of traditional Chinese medicine

Chinese Medicine, 2023
Network pharmacology can ascertain the therapeutic mechanism of drugs for treating diseases at the level of biological targets and pathways. The effective mechanism study of traditional Chinese medicine (TCM) characterized by multi-component, multi ...
Ling Li, Lele Yang, Liuqing Yang, Chunrong He, Yuxin He, Liping Chen, Qin Dong, Huaiying Zhang, Shiyun Chen, Peng Li   +9 more
doaj   +1 more source

Mechanism of Action of Hawthorn Leaves against Hyperlipidemia Based on Network Pharmacology and Preliminary Validation Study

Shipin gongye ke-ji, 2022
Objective: Network pharmacology was used to predict potential compounds, targets and pathways of action in hawthorn leaves for the treatment of hyperlipidaemia, and the network pharmacology predictions were validated in conjunction with target enzyme and
Xuegui LIU, Zhiming LI, Changfeng LIU, Jingyao ZHOU, Yaoyao WANG, Pinyi GAO, Danqi LI   +6 more
doaj   +1 more source

Application of network pharmacology in the study of mechanism of Chinese medicine in the treatment of ulcerative colitis: A review

Frontiers in Bioinformatics, 2022
Network pharmacology is a research method based on a multidisciplinary holistic analysis of biological systems, which coincides with the idea of the holistic view of traditional Chinese medicine.
Shihao Zheng, Tianyu Xue, Bin Wang, Haolin Guo, Qiquan Liu, Qiquan Liu   +5 more
doaj   +1 more source