Results 1 to 10 of about 339,960 (301)

Tinnitus: Network pathophysiology-network pharmacology [PDF]

Frontiers in Systems Neuroscience, 2012
Tinnitus, the phantom perception of sound, is a prevalent disorder. One in 10 adults has clinically significant subjective tinnitus, and for 1 in 100, tinnitus severely affects their quality of life. Despite the significant unmet clinical need for a safe
Ana Belen eElgoyhen, Berthold eLangguth, Sven eVanneste, Dirk eDe Ridder   +3 more
doaj   +4 more sources

Network pharmacology: curing causal mechanisms instead of treating symptoms [PDF]

Trends in Pharmacological Sciences, 2022
Para enfermedades complejas, la mayoría de los medicamentos son altamente ineficaces y la tasa de éxito del descubrimiento de fármacos está en constante declive. Si bien la baja calidad, los problemas de reproducibilidad y la irrelevancia traslacional de la mayoría de las investigaciones básicas y preclínicas han contribuido a esto, la actual ...
Cristian Nogales, Zeinab M. Mamdouh, Markus List, Christina Kiel, Ana I. Casas, Harald Schmidt   +5 more
openaire   +6 more sources

Research trends and hotspots of neurodegenerative diseases employing network pharmacology: A bibliometric analysis

Frontiers in Pharmacology, 2023
Background: Employing network pharmacology in neurodegenerative diseases (NDs) has been extensively studied recently. However, no comprehensive study has conducted on this subject employing bibliometrics so far.
Jie Zhu, Qingchun Liang, Siyi He, Chen Wang, Xiafei Lin, Duozhi Wu, Guanwen Lin, Zhihua Wang   +7 more
doaj   +1 more source

Progress and Prospects of Research Ideas and Methods in the Network Pharmacology of Traditional Chinese Medicine

Journal of Pharmacy & Pharmaceutical Sciences, 2022
In recent years, the emerging network pharmacology has been extensively applied to the field of traditional Chinese medicine and has made great contributions to the modernization of TCM.
Zhongzhu Yuan, Yingying Pan , Tian Leng, Yu Chu, Haojie Zhang, Jingru Ma, Xiaoju Ma   +6 more
doaj   +1 more source

INPUT: An intelligent network pharmacology platform unique for traditional Chinese medicine

Computational and Structural Biotechnology Journal, 2022
The application of network pharmacology has greatly promoted the scientific interpretation of disease treatment mechanism of traditional Chinese medicine (TCM).
Xianhai Li, Qiang Tang, Fanbo Meng, Pufeng Du, Wei Chen   +4 more
doaj   +1 more source

Network pharmacology: a bright guiding light on the way to explore the personalized precise medication of traditional Chinese medicine

Chinese Medicine, 2023
Network pharmacology can ascertain the therapeutic mechanism of drugs for treating diseases at the level of biological targets and pathways. The effective mechanism study of traditional Chinese medicine (TCM) characterized by multi-component, multi ...
Ling Li, Lele Yang, Liuqing Yang, Chunrong He, Yuxin He, Liping Chen, Qin Dong, Huaiying Zhang, Shiyun Chen, Peng Li   +9 more
doaj   +1 more source

Mechanism of Action of Hawthorn Leaves against Hyperlipidemia Based on Network Pharmacology and Preliminary Validation Study

Shipin gongye ke-ji, 2022
Objective: Network pharmacology was used to predict potential compounds, targets and pathways of action in hawthorn leaves for the treatment of hyperlipidaemia, and the network pharmacology predictions were validated in conjunction with target enzyme and
Xuegui LIU, Zhiming LI, Changfeng LIU, Jingyao ZHOU, Yaoyao WANG, Pinyi GAO, Danqi LI   +6 more
doaj   +1 more source

Application of network pharmacology in the study of mechanism of Chinese medicine in the treatment of ulcerative colitis: A review

Frontiers in Bioinformatics, 2022
Network pharmacology is a research method based on a multidisciplinary holistic analysis of biological systems, which coincides with the idea of the holistic view of traditional Chinese medicine.
Shihao Zheng, Tianyu Xue, Bin Wang, Haolin Guo, Qiquan Liu, Qiquan Liu   +5 more
doaj   +1 more source

Effect of Fushengong Decoction on PTEN/PI3K/AKT/NF-κB Pathway in Rats With Chronic Renal Failure via Dual-Dimension Network Pharmacology Strategy

Frontiers in Pharmacology, 2022
Overview: The treatment of chronic renal failure (CRF) with traditional Chinese medicine has attracted much attention, but its mechanism is not clear. Network pharmacology is an effective strategy for exploring the interaction mechanisms between Chinese ...
Hongyu Luo, Munan Wang, Ke Xu, Qiyao Peng, Bo Zou, Shi Yin, Chao Yu, Lingyan Ren, Ping Li, Li Tang, Yongbo Peng, Xuekuan Huang   +11 more
doaj   +1 more source

SmartGraph: A Network Pharmacology Investigation Platform [PDF]

Journal of Cheminformatics, 2019
AbstractMotivationDrug discovery investigations need to incorporate network pharmacology concepts while navigating the complex landscape of drug-target and target-target interactions. This task requires solutions that integrate high-quality biomedical data, combined with analytic and predictive workflows as well as efficient visualization.
Zahoránszky-Kőhalmi, Gergely, Sheils, Timothy, Oprea, Tudor I.   +2 more
openaire   +5 more sources