Results 11 to 20 of about 143,043 (264)
Frontiers in Bioinformatics, 2022 Network pharmacology is a research method based on a multidisciplinary holistic analysis of biological systems, which coincides with the idea of the holistic view of traditional Chinese medicine.
Shihao Zheng +5 more
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Frontiers in Pharmacology, 2022 Overview: The treatment of chronic renal failure (CRF) with traditional Chinese medicine has attracted much attention, but its mechanism is not clear. Network pharmacology is an effective strategy for exploring the interaction mechanisms between Chinese ...
Hongyu Luo +11 more
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Network analyses in systems pharmacology [PDF]
Bioinformatics, 2009 Abstract Systems pharmacology is an emerging area of pharmacology which utilizes network analysis of drug action as one of its approaches. By considering drug actions and side effects in the context of the regulatory networks within which the drug targets and disease gene products function, network analysis promises to greatly increase ...
Seth I. Berger, Ravi Iyengar
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Network pharmacology of JAK inhibitors [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance JAK kinase inhibitors (JAKis) have advanced options for treatment of autoimmune diseases. Because JAKs are signaling hubs for several cytokine receptors, JAKis’ overall impact on the immune system and how they actually improve diseases like rheumatoid arthritis remain poorly understood.
Devapregasan, Moodley +10 more
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SmartGraph: A Network Pharmacology Investigation Platform [PDF]
Journal of Cheminformatics, 2019 Abstract Motivation Drug discovery investigations need to incorporate network pharmacology concepts while navigating the complex landscape of drug-target and target-target interactions. This task requires solutions that integrate high-quality biomedical data, combined with analytic and predictive ...
Gergely Zahoránszky-Köhalmi +2 more
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Chinese Medicine, 2021 Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic cancer (PC) treatment has not been
Chao Wu +15 more
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Frontiers in Pharmacology, 2022 Objective: Network pharmacology provides new methods and references for the research of traditional Chinese medicine, but some problems remain, such as single evaluation components and index methods, imperfect relevant databases, unscientific prediction ...
Yu-Qing Tan +3 more
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Molecular networks for the study of TCM Pharmacology [PDF]
Briefings in Bioinformatics, 2009 To target complex, multi-factorial diseases more effectively, there has been an emerging trend of multi-target drug development based on network biology, as well as an increasing interest in traditional Chinese medicine (TCM) that applies a more holistic treatment to diseases.
Jing Zhao 0003 +2 more
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Frontiers in Pharmacology, 2021 Myocardial ischemia (MI) is one of the most common cardiovascular diseases with high incidence and mortality. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic traditional Chinese prescription to clear “heat” and “poison”.
Li Li +8 more
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Pharmacological mechanism of JiaWeiSiWu granule in the treatment of hypertension based on network pharmacology [PDF]
Annals of Palliative Medicine, 2021 JiaWeiSiWu granule (JWSWG) has been applied clinically for more than a decade, and the preliminary results show that blood pressure can be reduced while protecting the target organ at the same time. The purpose of this research is to study the pharmacological mechanism of JWSWG in treating hypertension using network pharmacology.The chief active ...
Lun, Chen +5 more
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