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Clinical Pharmacology in the UK, c.1950-2000: Influences and Institutions [PDF]
, 2008 Annotated and edited transcript of a Witness Seminar held on 6 February 2007. Introduction by Dr Mark Walport, The Wellcome Trust.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2008.©The Trustee of the Wellcome Trust ...
Reynolds, LA, Tansey, EM
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Shipin gongye ke-ji, 2022 Objective: Network pharmacology was used to predict potential compounds, targets and pathways of action in hawthorn leaves for the treatment of hyperlipidaemia, and the network pharmacology predictions were validated in conjunction with target enzyme and
Xuegui LIU +6 more
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Frontiers in Bioinformatics, 2022 Network pharmacology is a research method based on a multidisciplinary holistic analysis of biological systems, which coincides with the idea of the holistic view of traditional Chinese medicine.
Shihao Zheng +5 more
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Good Research Practice in Non-Clinical Pharmacology and Biomedicine [PDF]
, 2020 This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical ...
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Frontiers in Pharmacology, 2022 Overview: The treatment of chronic renal failure (CRF) with traditional Chinese medicine has attracted much attention, but its mechanism is not clear. Network pharmacology is an effective strategy for exploring the interaction mechanisms between Chinese ...
Hongyu Luo +11 more
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Network pharmacology of JAK inhibitors [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance JAK kinase inhibitors (JAKis) have advanced options for treatment of autoimmune diseases. Because JAKs are signaling hubs for several cytokine receptors, JAKis’ overall impact on the immune system and how they actually improve diseases like rheumatoid arthritis remain poorly understood.
Devapregasan, Moodley +10 more
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Introduction to dynamical systems analysis in quantitative systems pharmacology: basic concepts and applications [PDF]
, 2020 Quantitative systems pharmacology (QSP) can be regarded as a hybrid of pharmacometrics and systems biology. Here, we introduce the basic concepts related to dynamical systems theory that are fundamental to the analysis of systems biology models ...
채동우
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Network analyses in systems pharmacology [PDF]
Bioinformatics, 2009 Abstract Systems pharmacology is an emerging area of pharmacology which utilizes network analysis of drug action as one of its approaches. By considering drug actions and side effects in the context of the regulatory networks within which the drug targets and disease gene products function, network analysis promises to greatly increase ...
Seth I. Berger, Ravi Iyengar
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SmartGraph: A Network Pharmacology Investigation Platform [PDF]
Journal of Cheminformatics, 2019 Abstract Motivation Drug discovery investigations need to incorporate network pharmacology concepts while navigating the complex landscape of drug-target and target-target interactions. This task requires solutions that integrate high-quality biomedical data, combined with analytic and predictive ...
Gergely Zahoránszky-Köhalmi +2 more
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Chinese Medicine, 2021 Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic cancer (PC) treatment has not been
Chao Wu +15 more
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