Results 11 to 20 of about 339,960 (301)
Network‐based Approaches in Pharmacology [PDF]
Molecular Informatics, 2017 AbstractIn drug discovery, network‐based approaches are expected to spotlight our understanding of drug action across multiple layers of information. On one hand, network pharmacology considers the drug response in the context of a cellular or phenotypic network.
Baptiste, Boezio +3 more
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Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment
Frontiers in Pharmacology, 2019 The research field of systems biology has greatly advanced and, as a result, the concept of network pharmacology has been developed. This advancement, in turn, has shifted the paradigm from a “one-target, one-drug” mode to a “network-target, multiple ...
Runzhi Zhang +3 more
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Network Pharmacology Approach for Medicinal Plants: Review and Assessment
Pharmaceuticals, 2022 Natural products have played a critical role in medicine due to their ability to bind and modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive scaffolds for the treatment of multiple disorders.
Fatima Noor +5 more
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Network pharmacology of JAK inhibitors [PDF]
Proceedings of the National Academy of Sciences, 2016 SignificanceJAK kinase inhibitors (JAKis) have advanced options for treatment of autoimmune diseases. Because JAKs are signaling hubs for several cytokine receptors, JAKis’ overall impact on the immune system and how they actually improve diseases like rheumatoid arthritis remain poorly understood.
Devapregasan, Moodley +10 more
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Systematically Deciphering the Pharmacological Mechanism of Fructus Aurantii via Network Pharmacology [PDF]
Evidence-Based Complementary and Alternative Medicine, 2021 Fructus Aurantii (FA) is a traditional herbal medicine that has been widely used for thousands of years in China and possesses a variety of pharmacological effects. However, the active ingredients in FA and the potential mechanisms of its therapeutic effects have not been fully explored.
Qionglong Jin +5 more
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Network analyses in systems pharmacology [PDF]
Bioinformatics, 2009 Abstract Systems pharmacology is an emerging area of pharmacology which utilizes network analysis of drug action as one of its approaches. By considering drug actions and side effects in the context of the regulatory networks within which the drug targets and disease gene products function, network analysis promises to greatly increase ...
Seth I, Berger, Ravi, Iyengar
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Frontiers in Pharmacology, 2022 Objective: Network pharmacology provides new methods and references for the research of traditional Chinese medicine, but some problems remain, such as single evaluation components and index methods, imperfect relevant databases, unscientific prediction ...
Yu-Qing Tan +3 more
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Chinese Medicine, 2021 Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic cancer (PC) treatment has not been
Chao Wu +15 more
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Frontiers in Pharmacology, 2021 Myocardial ischemia (MI) is one of the most common cardiovascular diseases with high incidence and mortality. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic traditional Chinese prescription to clear “heat” and “poison”.
Li Li +8 more
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Is there a potential of misuse for venlafaxine and bupropion? [PDF]
, 2018 © 2018 Schifano and Chiappini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the ...
Anderson +64 more
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