Results 41 to 50 of about 339,960 (301)

The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology

Biomolecules, 2019
Natural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods to decipher the potential mechanisms of THM.
Won-Yung Lee, Choong-Yeol Lee, Youn-Sub Kim, Chang-Eop Kim   +3 more
doaj   +1 more source

Analytic lymph node number establishes staging accuracy by occult tumor burden in colorectal cancer. [PDF]

, 2012
BACKGROUND AND OBJECTIVES: Recurrence in lymph node-negative (pN0) colorectal cancer suggests the presence of undetected occult metastases. Occult tumor burden in nodes estimated by GUCY2C RT-qPCR predicts risk of disease recurrence.
Barkun, Alan, Hyslop, Terry, Schulz, Stephanie, Waldman, Scott A., Weinberg, David S.   +4 more
core   +2 more sources

Network Pharmacology

, 2017
The one-drug/one-target/one-disease approach to drug discovery is presently facing many challenges of safety, efficacy, and sustainability. Network biology and polypharmacology approaches gained appreciation recently as methods for omics data integration and multitarget drug development, respectively.
Chandran, Uma, Mehendale, Neelay, Patil, Saniya, Chaguturu, Rathnam, Patwardhan, Bhushan   +4 more
openaire   +1 more source

Network Pharmacology in Traditional Chinese Medicine [PDF]

Evidence-Based Complementary and Alternative Medicine, 2014
Network pharmacology is becoming a cutting-edge research field in current drug discovery and drug development thanks to rapid progress in systems biology, network biology, and chemical biology. By integrating reductionist and systems approaches as well as computational and experimental methods, network pharmacology has great potential to act as the ...
Li, Shao, Fan, Tai-Ping, Jia, Wei, Lu, Aiping, Zhang, Weidong   +4 more
openaire   +3 more sources

Combining metabolomics and network pharmacology to investigate the protective effect of Jiawei Xinglou Chengqi Granules in ischemic stroke [PDF]

Brazilian Journal of Medical and Biological Research
Jiawei Xinglou Chengqi Granule (JXCG) is an effective herbal medicine for the treatment of ischemic stroke (IS). JXCG has been shown to effectively ameliorate cerebral ischemic symptoms in clinical practice, but the underlying mechanisms are unclear.
Raoqiong Wang, Linshen Mao, Pan Liang, Yulu Gan, Qixue Gao, Shizhi Liang, Dechou Zhang, Gang Luo, Sijin Yang   +8 more
doaj   +1 more source

Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine [PDF]

, 2019
Here we describe a collaboration between industry, the National Health Service (NHS) and academia that sought to demonstrate how early understanding of both pharmacology and genomics can improve strategies for the development of precision medicines ...
A Cilli, AA Agyeman, AE Tilley, AL Chokas, AV Biankin, C-H Chou, Carolyn Low, Colin N. A. Palmer, D Cook, David C. Bunton, David Mallinson, E Arif, Elaine M. Gourlay, Erika Cecchin, G Faura Tellez, Graeme Macluskie, H Yang, Hannah Child, J Milara, J-R Yu, Jane Hair, K Linhart, Karen Cowan, Linda Cheyne, M Zanoni, Marian McNeil, Max Bylesjo, ME Ezzie, Michael Finch, MR Trusheim, NJ Schork, PA André, Pamela Brankin, RC Gentleman, S Purcell, Sarah Lynagh, SI Rennard, SJ Mandrekar, SM Paul, T Yang, W Asghar, WE Johnson, Y Chen   +42 more
core   +2 more sources

The Analysis of Existing Experience for the Ethnobotanical Information System [PDF]

, 2019
Ethnobotanical researches reflect the conventional learning of a region. Over the previous decade, medical plants which used for healing indigenous people has become a significant notion among the people and impacted improvement of scientific and ...
Hamidova, L. F. (Laman)
core   +3 more sources

Network pharmacology: a crucial approach in traditional Chinese medicine research

Chinese Medicine
Network pharmacology plays a pivotal role in systems biology, bridging the gap between traditional Chinese medicine (TCM) theory and contemporary pharmacological research.
Yiyan Zhai, Liu Liu, Fanqin Zhang, Xiaodong Chen, Haojia Wang, Jiying Zhou, Keyan Chai, Jiangying Liu, Huiling Lei, Peiying Lu, Meiling Guo, Jincheng Guo, Jiarui Wu   +12 more
doaj   +1 more source

The resistible decline of European science [PDF]

, 2011
Using a new data set that allows us to analyze precisely the research output in all fields of science, we show that the gap in scientific performance between Europe, especially continental Europe, and Anglo-Saxon countries, especially the USA, is large ...
Bauwens, Luc, Mion, Giordano, Thisse, Jacques-François   +2 more
core   +2 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source