Results 61 to 70 of about 153,471 (262)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Network pharmacology approach for validation of traditional claims of Ayurvedic medicines [PDF]

Network Biology
Ayurveda, an ancient holistic healing system originating from India emphasizes balance and harmony between body, mind, and spirit. Ayurvedic medicines offer diverse therapeutic claims, spanning preventive care, disease treatment, and overall well-being ...
Suvarna Ingale, Tejal Bele, Pramod Ingale   +2 more
doaj  

Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt

Scientific Reports
The well-established tumor suppressor, Breast Cancer Susceptibility Gene 1 (BRCA1), has been implicated in lipid metabolism and in paradoxically promoting hepatocellular carcinoma (HCC); yet its mechanistic role remains unknown.
Martha Ghebreselassie, Yoo Jin Park, Diana Nakib, David Dodington, Parasvi Patel, Sohyun Won, Anne Hakem, Razqallah Hakem, Sonya MacParland, Minna Woo   +9 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Network Pharmacology Analysis of the Potential Pharmacological Mechanism of a Sleep Cocktail

Biomolecules
Insomnia, also known as sleeplessness, is a sleep disorder due to which people have trouble sleeping, followed by daytime sleepiness, low energy, irritability, and a depressed mood. It may result in an increased risk of accidents of all kinds as well as problems focusing and learning.
Yuyun Liang, Yanrong Lv, Jing Qin, Wenbin Deng   +3 more
openaire   +3 more sources

Computer-aided drug design to generate a unique antibiotic family

Nature Communications
The World Health Organization has identified antibiotic resistance as one of the three greatest threats to human health. The need for antibiotics is a pressing matter that requires immediate attention.
Christopher J. Barden, Fan Wu, J. Pedro Fernandez-Murray, Erhu Lu, Shengguo Sun, Marcia M. Taylor, Annette L. Rushton, Jason Williams, Mahtab Tavasoli, Autumn Meek, Alla Siva Reddy, Lisa M. Doyle, Irina Sagamanova, Kovilpitchai Sivamuthuraman, Robert T. M. Boudreau, David M. Byers, Donald F. Weaver, Christopher R. McMaster   +17 more
doaj   +1 more source

Clinical practice guidelines for translating pharmacogenomic knowledge to bedside. Focus on anticancer drugs.

Frontiers in Pharmacology, 2014
The development of clinical practice recommendations or guidelines for the clinical use of pharmacogenomics data is an essential issue for improving drug therapy, particularly for drugs with high toxicity and/or narrow therapeutic index such as ...
José A G Agúndez, José A G Agúndez, Gara eEsguevillas, Gara eEsguevillas, Gemma eAmo, Gemma eAmo, Elena eGarcía-Martín, Elena eGarcía-Martín   +7 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons

eLife, 2016
Corticostriatal afferents can engage parvalbumin-expressing (PV+) interneurons to rapidly curtail the activity of striatal projection neurons (SPNs), thus shaping striatal output.
Farid N Garas, Rahul S Shah, Eszter Kormann, Natalie M Doig, Federica Vinciati, Kouichi C Nakamura, Matthijs C Dorst, Yoland Smith, Peter J Magill, Andrew Sharott   +9 more
doaj   +1 more source