Results 81 to 90 of about 17,342 (262)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Network pharmacology approach for validation of traditional claims of Ayurvedic medicines [PDF]
Network BiologyAyurveda, an ancient holistic healing system originating from India emphasizes balance and harmony between body, mind, and spirit. Ayurvedic medicines offer diverse therapeutic claims, spanning preventive care, disease treatment, and overall well-being ...
Suvarna Ingale +2 more
doaj
Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt
Scientific ReportsThe well-established tumor suppressor, Breast Cancer Susceptibility Gene 1 (BRCA1), has been implicated in lipid metabolism and in paradoxically promoting hepatocellular carcinoma (HCC); yet its mechanistic role remains unknown.
Martha Ghebreselassie +9 more
doaj +1 more source
Clinical Pharmacology in the UK, c.1950-2000: Influences and Institutions
, 2008 Annotated and edited transcript of a Witness Seminar held on 6 February 2007. Introduction by Dr Mark Walport, The Wellcome Trust.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2008.©The Trustee of the Wellcome Trust ...
Reynolds, LA, Tansey, EM
core
Osteoarthritis (OA) is a debilitating joint disorder characterized by cartilage degradation and disruption of chondrocyte homeostasis. Although retinoic acid (RA) has been used in OA models, its precise targets are not clear.
Dao-Fang Ding +5 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Network Pharmacology Analysis of the Potential Pharmacological Mechanism of a Sleep Cocktail
BiomoleculesInsomnia, also known as sleeplessness, is a sleep disorder due to which people have trouble sleeping, followed by daytime sleepiness, low energy, irritability, and a depressed mood. It may result in an increased risk of accidents of all kinds as well as problems focusing and learning.
Yuyun Liang +3 more
openaire +3 more sources
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Computer-aided drug design to generate a unique antibiotic family
Nature CommunicationsThe World Health Organization has identified antibiotic resistance as one of the three greatest threats to human health. The need for antibiotics is a pressing matter that requires immediate attention.
Christopher J. Barden +17 more
doaj +1 more source
eLife, 2016 Corticostriatal afferents can engage parvalbumin-expressing (PV+) interneurons to rapidly curtail the activity of striatal projection neurons (SPNs), thus shaping striatal output.
Farid N Garas +9 more
doaj +1 more source