Results 91 to 100 of about 17,342 (262)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Clinical practice guidelines for translating pharmacogenomic knowledge to bedside. Focus on anticancer drugs.

Frontiers in Pharmacology, 2014
The development of clinical practice recommendations or guidelines for the clinical use of pharmacogenomics data is an essential issue for improving drug therapy, particularly for drugs with high toxicity and/or narrow therapeutic index such as ...
José A G Agúndez, José A G Agúndez, Gara eEsguevillas, Gara eEsguevillas, Gemma eAmo, Gemma eAmo, Elena eGarcía-Martín, Elena eGarcía-Martín   +7 more
doaj   +1 more source

Network Pharmacology and Transcriptomics to Explore the Pharmacological Mechanisms of 20(S)-Protopanaxatriol in the Treatment of Depression

Depression is one of the most common psychological disorders nowadays. Studies have shown that 20(S)-protopanaxatriol (PPT) can effectively improve depressive symptoms in mice. However, its mechanism needs to be further explored.
Lili Su, Weijia Chen, Ying Zong, Rui Du, Jianming Li, Meiling Shi, Xiangjuan Guo, Zhongmei He, Li Sun, Jianan Geng   +9 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Integrative analysis of Trichosanthes kirilowii maxim formula granules’ anti-triple-negative breast cancer mechanism via network pharmacology, metabolomics, and molecular pharmacology

Frontiers in Pharmacology
BackgroundTriple-negative breast cancer (TNBC) urgently needs effective therapies due to limited targeted options and unfavorable outcomes. We investigated Trichosanthes kirilowii Maxim formula granules (TKM) using integrated network pharmacology ...
Yuzhen Gao, Yuzhen Gao, Yan Lu, Yan Lu, Yaping Liu, Fen Liu, Jiaqi Zhang, Fei Xu, Zongwen Ji, Tian Fu, Shulong Shi, Shulong Jiang   +11 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Exploring the mechanism of action of rehmannia glutinosa for the treatment of gastric cancer based on network pharmacology [PDF]

Brazilian Journal of Pharmaceutical Sciences
This study investigates the molecular mechanisms of Rehmannia glutinosa in gastric cancer treatment using network pharmacology, supported by experimental validation.
Han Yongguang, Zhao Yingyi, Tan Yalan, Chen Yuexin, Lv Xing   +4 more
doaj   +1 more source

Investigating the Mechanism of Action of Ipomoea pes-caprae in the Treatment of Rheumatoid Arthritis Based on Serum Metabolomics and Network Pharmacology

Ipomoea pes-caprae (L.) Sweet (Convolvulaceae) is a commonly used marine Chinese medicine in the coastal areas of southern China. Traditionally, it has been used in the treatment of rheumatoid arthritis (RA).
Zhengcai Du, Xiaotao Hou, Siwei Li, Jinling Xie, Xianglong Pan, Erwei Hao, Juan Wen, Jiagang Deng, Fangfei Zhong   +8 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Best practices to maximize the use and reuse of quantitative and systems pharmacology models: recommendations from the United Kingdom quantitative and systems pharmacology network [PDF]

, 2018
The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts.
Chappell, Michael J, Malik-Sheriff, Rahuman S., James W. T. Yates, Lourdes Cucurull‐Sanchez, Marcus J. Tindall, Cucurull‐Sanchez, Lourdes, Timmis, Jonathan, Cheung, Amy, Piet H. van der Graaf, Yates, James W T, Michael J. Chappell, Yates, James W. T., Rahuman S. Malik‐Sheriff, Phipps, Alex, Tindall, Marcus J., S. Y. Amy Cheung, Mark Penney, Timmis, Jon, van der Graaf, Piet, Amy Cheung, S. Y., Malik-Sheriff, Rahuman, Cucurull-Sanchez, Lourdes, Piet H. van derGraaf, Graaf, Piet H., van der Graaf, Piet H., Vicini, Paolo, Vijayalakshmi Chelliah, van der Graaf, Piet H, Paolo Vicini, Yates, James, Gianne Derks, Penney, Mark, Tindall, Marcus J, Alex Phipps, Chappell, Michael J., Chappell, Michael, Chelliah, Vijayalakshmi, Derks, Gianne, Malik-Sheriff, Rahuman S, Jon Timmis, Amy Cheung, S Y, Malik‐Sheriff, Rahuman S., Tindall, Marcus   +42 more
core   +1 more source