Results 111 to 120 of about 339,960 (301)

Pharmacological mechanisms of berberine against triple negative breast cancer: Integration of network pharmacology and experimental validation

Phytomedicine Plus
Objective: Berberine (BBR) has garnered attention for its potential effectiveness against triple-negative breast cancer (TNBC). To further understand its pharmacological mechanisms, this study employed a combination of network pharmacology analysis and ...
Tian Qin, Kaixuan Liu, Yushi Yang, Jinjin Huang, Tengxiang Chen, Yinhui Jiang, Shu Xu   +6 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Effect of Renal Impairment on the Pharmacokinetics of Memantine

Journal of Pharmacological Sciences, 2012
The effect of renal impairment on the pharmacokinetics of a single oral dose of memantine (10 mg) was determined in Japanese subjects. Subjects were assigned to four groups based on baseline creatinine clearance (CLCR): normal renal function (> 80 mL/min,
Takashi Moritoyo, Tomoko Hasunuma, Kazuhiro Harada, Tomonori Tateishi, Makoto Watanabe, Tsutomu Kotegawa, Masahiro Nagai, Yuji Kumagai, Tomomichi Fujitani, Takahumi Okura, Tomikazu Fukuoka, Kenichi Miyoshi, Bunzo Matsuura, Shinya Furukawa, Tomoe Kobori, Hiroyoko Moritoyo, Noriko Nishikawa, Tomoaki Tsujii, Hirotaka Iwaki, Masahiko Nakamura, Satoshi Makino, Kei Ohnuma, Koichiro Yuji, Megumi Hashimoto, Masaru Takasu, Yutaka Hashizume, Koji You, Tomoko Matsumura, Yuji Tanaka, Nahoko Matsumoto, Junichi Nakamura, Jun Miura, Tadao Akizawa, Kozo Kitazawa, Takanori Shibata, Aki Kuroki, Hirokazu Honda, Masanori Mukai, Kyoichi Ohashi, Takuya Morimoto, Hiromitsu Imai, Toshiaki Okudaira, Fuminori Sato, Junko Imanaga, Katsuhiro Tanaka, Masahiro Nomoto   +45 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Danhong injection alleviates OGD-induced blood-brain barrier injury via VEGFR2/PI3K/AKT pathway based on network pharmacology and experimental evidence

Journal of Holistic Integrative Pharmacy
Objective: Previous studies have shown that Danhong injection (DHI) has a protective effect on the blood-brain barrier (BBB) function after ischemic stroke.
Yutong Zhang, Meixia Xie, Jiayin Liang, Li Li, Shumei Wang, Minghua Xian   +5 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Multitarget Mechanism of Plants to Fight Respiratory Tract Infections Based on Network Pharmacology and Molecular Docking

Natural Product Communications
Objective: To study the mechanism of Artemisia in the treatment of respiratory tract infection (RTI) by network pharmacology and molecular docking.
Zhao-zhen Xu, Zhi-xin Sun, Farukh-S Sharopov, William-N Setzer, Yan-fang Sun   +4 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Network pharmacology and experimental evidence: MAPK signaling pathway is involved in the anti-asthma roles of Perilla frutescens leaf

Heliyon
Perilla frutescens (PF) leaf is a traditional Chinese medicine and food with beneficial effects on allergic asthma. We sought to elucidate the active compounds, the targets, and underlying mechanisms of PF leaf in the treatment of allergic asthma by ...
Mingzhuo Cao, Mengling Zhan, Heyun Jing, Zeqian Wang, Yuan Wang, Xiumin Li, Mingsan Miao   +6 more
doaj   +1 more source