Results 131 to 140 of about 4,728,401 (305)

A Novel KCNA1 Variant in a Patient With Tremor and Autism Spectrum Disorder Causes Mixed LOF/GOF Defects of Kv1.1 Channels

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Variants in KCNA1, encoding the Kv1.1 potassium channel, cause neurological disorders including episodic ataxia and developmental and epileptic encephalopathy. We identified a novel KCNA1 variant (A401T) in a 16‐year‐old patient with autism spectrum disorder, borderline intellectual disability, and tremor, without episodic ataxia or epilepsy ...
Juan Darío Ortigoza‐Escobar, Laura Marti‐Sánchez, Loreto Martorell, Giorgia Dinoi, Antonio Vittorio Buono, Annamaria De Luca, Antonella Liantonio, Paola Imbrici   +7 more
wiley   +1 more source

The Potential of Siraitia grosvenorii to Promote Bone Regeneration via Modulating Macrophage Polarization: A Network Pharmacology and Experimental Study

Siraitia grosvenorii (SG), a traditional Chinese medicinal herb, possesses immunomodulatory and osteoinductive properties, yet its pharmacological mechanisms in bone defect repair remain largely unexplored.
Yuying Mai, Yang Qiao, Lufei Wang, Yuan Qin, Hongbing Liao, Linhui Huang   +5 more
core   +1 more source

Catholic Women's Network, July / August, 1996

, 1996
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core   +1 more source

Molecular Mechanism of Sangmei Zhike Granules in Treating Allergic Asthma: Insights from UPLC-MS/MS and Network Pharmacology

Natural Product Communications
Background: Asthma has become an increasingly serious and prevalent public health issue. Chinese herbal medicine holds promising potential as an adjunctive therapy for asthma.
Kai Li, Shi-yu Zhang, Gui-rui Huang, Hong-sheng Cui   +3 more
doaj   +1 more source

Network pharmacology in food-medicine homology: AI-driven decoding of multi-target synergy from molecular networks to precision health

Acupuncture and Herbal Medicine
Network pharmacology provides a transformative framework for decoding multi-target, system-level mechanisms of the food-medicine homology (FMH) substances, overcoming the limitations of reductionist approaches by integrating multi-omics data ...
Deyang Sun, Pan Chen, Li Tao, Peng Ma, Lichong Meng, Shuting Yin, Bo Zhang, Shao Li   +7 more
doaj   +1 more source

Short‐Term Response to Biologic Therapy in Psoriatic Arthritis Is Not Influenced by Disease Duration at Initiation of Therapy

Arthritis Care &Research, EarlyView.
Objective We aimed to determine whether the short‐term response to biologics in biologic‐naive psoriatic arthritis (PsA) is better in patients initiating biologic treatment early in the disease course. Methods Patients with PsA who started on biologic therapy from the year 2000 to 2025 were included for analysis.
Sung Min Cho, Shangyi Gao, Daniel Pereira, Richard J. Cook, Dafna D. Gladman   +4 more
wiley   +1 more source

Pharmacology of general anesthetics

, 2017
A detailed insight into the pharmacology of general anesthetics. Classification of general anesthetics, mode of action and an in depth review of both, volatile and intravenous anesthetics.általános orvosangolOrvosbiológia-farmakológiaegységes ...
Bhikha, Mehul Dinesh
core  

The integration of network pharmacology and multiomics reveals the mechanism by which Malus hupehensis leaves inhibit acute liver injury

BMC Complementary Medicine and Therapies
Objective The leaves of Malus hupehensis (MH) are a medicinal and edible TCM with good liver protection, although its underlying mechanism remains unclear.
Jia-xin Qiao, Shu-jie Lv, Bing-tao Zhai, Xiu-lin Zhang, Jiang-xue Cheng, Jing Sun, Xiao-fei Zhang, Dong-yan Guo   +7 more
doaj   +1 more source

Mapping the Social Network Structure and Composition of Black Individuals With Rheumatic and Musculoskeletal Conditions

Arthritis Care &Research, EarlyView.
Objective Our objective was to describe the social networks of Black individuals with rheumatic and musculoskeletal conditions and understand the clustering of health‐related behaviors to inform future community‐based, peer‐led interventions. Methods We used an adapted Personal Network Survey for Clinical Research (PERSNET) to map the personal social ...
Taussia Boadi, Amar Dhand, Leah Santacroce, Neil Pillai, Komel Safdar, Mia T. Chandler, Ariel Childs, Monica Crespo‐Bosque, Gina Curry, Mary Dollear, Alice Eggleston, Daniel Erickson, Dieufort Fleurissaint, Denice Garrett, Gail Granville, Tyler Green, Magdalena Hamielec, Elena Losina, Karen Mancera‐Cuevas, Mary Ann Nelson, Chisa Nosamiefan, Bisola Ojikutu, Tonya S. Roberson, Mary Beth Son, Marie Jacques Toussaint, Michael York, Rosalind Ramsey‐Goldman, Candace H. Feldman   +27 more
wiley   +1 more source

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source