Results 101 to 110 of about 17,342 (262)

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Exploring the pathways and targets of Shexiang Baoxin pill for coronary heart disease through a network pharmacology approach

World Journal of Traditional Chinese Medicine, 2018
Objective: To investigate the network pharmacology of Shexiang Baoxin pill (SBP) and systematically analyze the mechanisms of SBP. Methods: In this study, we excavated all the targets of 26 constituents of SBP which were identified in rat plasma though ...
Shou-De Zhang, Zhan-Hai Su, Rui-Hui Liu, Yan-Yan Diao, Shi-Liang Li, Ya-Ping-Hua, Hong-Lin Li, Wei-Dong Zhang   +7 more
doaj   +1 more source

Network Pharmacology and Molecular Dynamics Identified Potential Androgen Receptor-Targeted Metabolites in Crocus alatavicus

The objective of this study is to identify the active components of Crocus alatavicus and potential targets through a combination of network pharmacology, molecular docking technology combined with molecular dynamics simulation, and binding free energy ...
Zhen Ding, Daoyuan Zhang, Bei Gao, Jichen Zhao, Yuanfeng Lu   +4 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Pharmacological mechanisms of berberine against triple negative breast cancer: Integration of network pharmacology and experimental validation

Phytomedicine Plus
Objective: Berberine (BBR) has garnered attention for its potential effectiveness against triple-negative breast cancer (TNBC). To further understand its pharmacological mechanisms, this study employed a combination of network pharmacology analysis and ...
Tian Qin, Kaixuan Liu, Yushi Yang, Jinjin Huang, Tengxiang Chen, Yinhui Jiang, Shu Xu   +6 more
doaj   +1 more source

Unraveling the Mechanisms of Madecassoside Derivatives in Wound Healing: Network Pharmacology and Experimental Validation

Background: Madecassoside is widely utilized in wound healing due to its multiple physiological activities. However, its limited bioavailability and solubility hinder its clinical application.
Cheng Yang, Jing Liu, Bingtian Zhao, Yuanyuan Li   +3 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

SmartGraph API: Programmatic Knowledge Mining in Network- Pharmacology Setting

The recent SmartGraph platform facilitates the execution of complex drug-discovery workflows with ease in the network-pharmacology paradigm. However, at the time of its publication, we identified the need for the development of an Application Programming
Jessica, Binder, Alexander G., Godfrey, Nathan, Miller, Dhatri V. L., Penna, Samuel G., Michael, Gergely, Zahoránszky-Kőhalmi, Hythem, Sidky, Jeyaraman, Soundarajan, Brett, Yang, Brandon, Walker, Sridhar, Vuyyuru, Tudor I., Oprea, Jennifer, King, Timothy, Sheils, Ke, Wang   +14 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source