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Molecular networks for the study of TCM Pharmacology [PDF]
Briefings in Bioinformatics, 2009 To target complex, multi-factorial diseases more effectively, there has been an emerging trend of multi-target drug development based on network biology, as well as an increasing interest in traditional Chinese medicine (TCM) that applies a more holistic treatment to diseases.
Jing Zhao 0003 +2 more
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Frontiers in Pharmacology, 2022 Objective: Network pharmacology provides new methods and references for the research of traditional Chinese medicine, but some problems remain, such as single evaluation components and index methods, imperfect relevant databases, unscientific prediction ...
Yu-Qing Tan +3 more
doaj +1 more source
Systematically Deciphering the Pharmacological Mechanism of Fructus Aurantii via Network Pharmacology [PDF]
Evidence-Based Complementary and Alternative Medicine, 2021 Fructus Aurantii (FA) is a traditional herbal medicine that has been widely used for thousands of years in China and possesses a variety of pharmacological effects. However, the active ingredients in FA and the potential mechanisms of its therapeutic effects have not been fully explored.
Qionglong Jin +5 more
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Clinical Relevance of Cyclic GMP Modulators: A Translational Success Story of Network Pharmacology [PDF]
, 2016 Therapies that modulate cyclic guanosine-30-50-monophosphate (cGMP) have emerged as one of the most successful areas in recent drug discovery and clinical pharmacology.
Frijhoff, J. +6 more
core +2 more sources
Frontiers in Pharmacology, 2021 Myocardial ischemia (MI) is one of the most common cardiovascular diseases with high incidence and mortality. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic traditional Chinese prescription to clear “heat” and “poison”.
Li Li +8 more
doaj +1 more source
Network Pharmacology and Pharmacological Mechanism of CV-3 in Atrial Fibrillation
Evidence-Based Complementary and Alternative Medicine, 2022 The high fatality and disability rate of atrial fibrillation (AF) strongly promote the development of pathogenesis and treatment of AF that is of great value. The present research attempted to clarify potential mechanisms of Mujiangzi oil (CV-3) in treating AF by constructing an AF cardiomyocytes model and using a network pharmacology approach.
Zundong Wang +5 more
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Frontiers in Endocrinology, 2023 Objective(-)-Epigallocatechin-3-gallate (EGCG) has preventive effects on obesity-related precocious puberty, but its underlying mechanism remains unclear.
Qiuyun Gu +8 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Network pharmacology was rapidly developed based on multidisciplinary holistic analysis of biological systems, which has become a popular tool in traditional Chinese medicine (TCM) research in recent years.
Shihao Zheng +5 more
doaj +1 more source
Bioscience Reports, 2022 Abstract Objective: Andrographis paniculata (Burm.f.) Nees is a medicinal plant that has been traditionally used as an anti-inflammatory and antibacterial remedy for several conditions. Andrographolide (AG), the active constituent of A. paniculata (Burm.f.) Nees, has anti-lipidic and anti-inflammatory properties as well as cardiovascular
Shuai Shi +8 more
openaire +2 more sources
iMeta, 2022 DNA‐based biological ingredient identification and downstream pharmacology network analysis are commonly used in research for Traditional Chinese Medicine preparations (TCM formulas).
Pengshuo Yang +8 more
doaj +1 more source