Results 21 to 30 of about 17,342 (262)

SmartGraph: A Network Pharmacology Investigation Platform [PDF]

Journal of Cheminformatics, 2019
Abstract Motivation Drug discovery investigations need to incorporate network pharmacology concepts while navigating the complex landscape of drug-target and target-target interactions. This task requires solutions that integrate high-quality biomedical data, combined with analytic and predictive ...
Gergely Zahoránszky-Köhalmi, Timothy Sheils, Tudor I. Oprea   +2 more
openaire   +5 more sources

A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

Chinese Medicine, 2021
Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic cancer (PC) treatment has not been
Chao Wu, Zhi-Hong Huang, Zi-Qi Meng, Xiao-Tian Fan, Shan Lu, Ying-Ying Tan, Lei-Ming You, Jia-Qi Huang, Antony Stalin, Pei-Zhi Ye, Zhi-Shan Wu, Jing-Yuan Zhang, Xin-Kui Liu, Wei Zhou, Xiao-Meng Zhang, Jia-Rui Wu   +15 more
doaj   +1 more source

Huoxue Qingre decoction used for treatment of coronary heart disease network analysis and metabolomic evaluation

Frontiers in Pharmacology, 2022
Objective: Network pharmacology provides new methods and references for the research of traditional Chinese medicine, but some problems remain, such as single evaluation components and index methods, imperfect relevant databases, unscientific prediction ...
Yu-Qing Tan, Min Jin, Xuan-Hui He, Heng-Wen Chen   +3 more
doaj   +1 more source

Molecular networks for the study of TCM Pharmacology [PDF]

Briefings in Bioinformatics, 2009
To target complex, multi-factorial diseases more effectively, there has been an emerging trend of multi-target drug development based on network biology, as well as an increasing interest in traditional Chinese medicine (TCM) that applies a more holistic treatment to diseases.
Jing Zhao 0003, Peng Jiang, Weidong Zhang 0003   +2 more
openaire   +2 more sources

Integrated Network Pharmacology and Metabonomics to Reveal the Myocardial Protection Effect of Huang-Lian-Jie-Du-Tang on Myocardial Ischemia

Frontiers in Pharmacology, 2021
Myocardial ischemia (MI) is one of the most common cardiovascular diseases with high incidence and mortality. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic traditional Chinese prescription to clear “heat” and “poison”.
Li Li, Weixing Dai, Wenting Li, Yumao Zhang, Yanqin Wu, Chenfeng Guan, Anye Zhang, Hui Huang, Yuzhen Li   +8 more
doaj   +1 more source

Clinical Relevance of Cyclic GMP Modulators: A Translational Success Story of Network Pharmacology [PDF]

, 2016
Therapies that modulate cyclic guanosine-30-50-monophosphate (cGMP) have emerged as one of the most successful areas in recent drug discovery and clinical pharmacology.
Frijhoff, J., Casas Guijarro, Ana, Oettrich, J. M., Hobbs, A. J., Schmidt, H. H. H. W., Dao, V. T., Kleikers, P. W. M.   +6 more
core   +1 more source

Pharmacological mechanism of JiaWeiSiWu granule in the treatment of hypertension based on network pharmacology [PDF]

Annals of Palliative Medicine, 2021
JiaWeiSiWu granule (JWSWG) has been applied clinically for more than a decade, and the preliminary results show that blood pressure can be reduced while protecting the target organ at the same time. The purpose of this research is to study the pharmacological mechanism of JWSWG in treating hypertension using network pharmacology.The chief active ...
Lun, Chen, Tong, Zhu, Jia, Qi, Yufeng, Zhang, Zigang, Zhang, Haitao, Liu   +5 more
openaire   +2 more sources

The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology

Frontiers in Endocrinology, 2023
Objective(-)-Epigallocatechin-3-gallate (EGCG) has preventive effects on obesity-related precocious puberty, but its underlying mechanism remains unclear.
Qiuyun Gu, Lina Xia, Qiuju Du, Ying Shao, Jieyi He, Peiying Wu, Lingwei Liang, Xiuhua Shen, Xiuhua Shen   +8 more
doaj   +1 more source

Network Pharmacology and Pharmacological Mechanism of CV-3 in Atrial Fibrillation

Evidence-Based Complementary and Alternative Medicine, 2022
The high fatality and disability rate of atrial fibrillation (AF) strongly promote the development of pathogenesis and treatment of AF that is of great value. The present research attempted to clarify potential mechanisms of Mujiangzi oil (CV-3) in treating AF by constructing an AF cardiomyocytes model and using a network pharmacology approach.
Zundong Wang, Zhen Zeng, Yongsheng Hu, Hengcan Sun, Ying Tang, Weiqin Liu   +5 more
openaire   +2 more sources

TCM‐Suite: A comprehensive and holistic platform for Traditional Chinese Medicine component identification and network pharmacology analysis

iMeta, 2022
DNA‐based biological ingredient identification and downstream pharmacology network analysis are commonly used in research for Traditional Chinese Medicine preparations (TCM formulas).
Pengshuo Yang, Jidong Lang, Hongjun Li, Jinxiang Lu, Hanyang Lin, Geng Tian, Hong Bai, Jialiang Yang, Kang Ning   +8 more
doaj   +1 more source