Results 31 to 40 of about 143,043 (264)

Multivariate Statistical Analysis of Metabolites in Anisodus tanguticus (Maxim.) Pascher to Determine Geographical Origins and Network Pharmacology

Frontiers in Plant Science, 2022
Anisodus tanguticus (Maxim.) Pascher, has been used for the treatment of septic shock, analgesia, motion sickness, and anesthesia in traditional Tibetan medicine for 2,000 years.
Chen Chen, Chen Chen, Bo Wang, Bo Wang, Jingjing Li, Feng Xiong, Guoying Zhou   +6 more
doaj   +1 more source

The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology

Biomolecules, 2019
Natural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods to decipher the potential mechanisms of THM.
Won-Yung Lee, Choong-Yeol Lee, Youn-Sub Kim, Chang-Eop Kim   +3 more
doaj   +1 more source

Network Pharmacology-Based Strategy for the Investigation of the Anti-Obesity Effects of an Ethanolic Extract of Zanthoxylum bungeanum Maxim

Frontiers in Pharmacology, 2020
Network pharmacology is considered as the next paradigm in drug discovery. In an era when obesity has become global epidemic, network pharmacology becomes an ideal tool to discover novel herbal-based therapeutics with effective anti-obesity effects ...
Ying Wang, Song Hong Yang, Keying Zhong, Ting Jiang, Mi Zhang, Hiu Yee Kwan, Tao Su   +6 more
doaj   +1 more source

Combining metabolomics and network pharmacology to investigate the protective effect of Jiawei Xinglou Chengqi Granules in ischemic stroke [PDF]

Brazilian Journal of Medical and Biological Research
Jiawei Xinglou Chengqi Granule (JXCG) is an effective herbal medicine for the treatment of ischemic stroke (IS). JXCG has been shown to effectively ameliorate cerebral ischemic symptoms in clinical practice, but the underlying mechanisms are unclear.
Raoqiong Wang, Linshen Mao, Pan Liang, Yulu Gan, Qixue Gao, Shizhi Liang, Dechou Zhang, Gang Luo, Sijin Yang   +8 more
doaj   +1 more source

Network Pharmacology

, 2017
The one-drug/one-target/one-disease approach to drug discovery is presently facing many challenges of safety, efficacy, and sustainability. Network biology and polypharmacology approaches gained appreciation recently as methods for omics data integration and multitarget drug development, respectively.
Chandran, Uma, Mehendale, Neelay, Patil, Saniya, Chaguturu, Rathnam, Patwardhan, Bhushan   +4 more
openaire   +1 more source

Network Pharmacology in Traditional Chinese Medicine [PDF]

Evidence-Based Complementary and Alternative Medicine, 2014
Network pharmacology is becoming a cutting-edge research field in current drug discovery and drug development thanks to rapid progress in systems biology, network biology, and chemical biology. By integrating reductionist and systems approaches as well as computational and experimental methods, network pharmacology has great potential to act as the ...
Li, Shao, Fan, Tai-Ping, Jia, Wei, Lu, Aiping, Zhang, Weidong   +4 more
openaire   +3 more sources

The Pharmacological Mechanisms of Xiaochaihutang in Treating Breast Cancer Based on Network Pharmacology

Contrast Media & Molecular Imaging, 2022
Background. As a classic prescription in Chinese medicine treatment, Xiaochaihutang (XCHT) can improve the clinical effect and reduce serum tumor markers in patients with breast cancer (BC). However, there has not been any study to confirm the mechanism. We used bioinformatics analysis and network pharmacology to find the potential targets.
Lin Zheng, Hongnan Jiang, Ruoqi Li, Liying Song, Ruihan Chen, Honglin Dong   +5 more
openaire   +2 more sources

Network pharmacology: a crucial approach in traditional Chinese medicine research

Chinese Medicine
Network pharmacology plays a pivotal role in systems biology, bridging the gap between traditional Chinese medicine (TCM) theory and contemporary pharmacological research.
Yiyan Zhai, Liu Liu, Fanqin Zhang, Xiaodong Chen, Haojia Wang, Jiying Zhou, Keyan Chai, Jiangying Liu, Huiling Lei, Peiying Lu, Meiling Guo, Jincheng Guo, Jiarui Wu   +12 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Integrative transcriptomic and network pharmacology analysis reveals the neuroprotective role of BYHWD through enhancing autophagy by inhibiting Ctsb in intracerebral hemorrhage mice

Chinese Medicine, 2023
Background In this study, we aimed to combine transcriptomic and network pharmacology to explore the crucial mRNAs and specific regulatory molecules of Buyang Huanwu Decoction (BYHWD) in intracerebral hemorrhage (ICH) treatment. Methods C57BL/6 mice were
Yiqing Cai, Zhe Yu, Xueping Yang, Weikang Luo, En Hu, Teng Li, Wenxin Zhu, Yang Wang, Tao Tang, Jiekun Luo   +9 more
doaj   +1 more source