Results 101 to 110 of about 14,636,985 (313)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Chinese Association of Greater Toledo newsletter, Winter, 2009

open access: yes, 2009
A newsletter published by the Chinese Association of Greater Toledo (CAGT). CAGT was founded in 1965 to support the Chinese community in and around Toledo, Ohio and uphold Chinese culture, language, and customs.
Chinese Association of Greater Toledo (Toledo, Ohio)
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More than a Cultural Celebration: The Politics of Chinese New Year in post-Suharto Indonesia [PDF]

open access: yes, 2009
In the aftermath of the May 1998 riots that forced President Suharto to step down, ethnic Chinese received unprecedented freedom to assert their long suppressed cultural and religious identity.
Chang-Yau Hoon   +2 more
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Chinese presence in real estate in South Africa and Mauritius [PDF]

open access: yes, 2016
Original document available at : http://www.ccs.org.za/Includes bibliographyChina has recently taken the global community by surprise with a surging interest in overseas real estate investment.
Cowaloosur, Honita
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A Set of Acupuncture Needles in the Late Qing Dynasty Collected by George Soulié de Morant

open access: yesChinese Medicine and Culture
. In the early 20th century, French vice-consul George Soulié de Morant encountered acupuncture during his visit to China, and then brought it back to France. After more than a century, his collection was transported from Paris, France to Kunming, China,
Han WANG   +4 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

Chinese Folklore Studies Today Discourse and Practice

open access: yes
Chinese folklorists are well acquainted with the work of their English-language colleagues, but until recently the same could not be said about American scholars' knowledge of Chinese folkloristics.
Zhang, Lijun., You, Ziying.
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Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan   +5 more
wiley   +1 more source

The Necessity and strategies for promoting Chinese character culture in the context of university general education in China

open access: yesCogent Education
This paper addresses the issue of declining proficiency in Chinese character culture among university students in China, particularly due to digitalization, foreign language emphasis, and test-oriented education. The study aims to highlight the necessity
Shengyu Zhu
doaj   +1 more source

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