Results 51 to 60 of about 574,514 (257)
Population size estimation for quality control of ChIP-Seq datasets.
PLoS ONE, 2019 Chromatin immunoprecipitation followed by sequencing, i.e. ChIP-Seq, is a widely used experimental technology for the identification of functional protein-DNA interactions.
Semyon K Kolmykov +5 more
doaj +1 more source
ChIP-seq analysis using PbAP2-FG2::GFP.
, 2023 (A) IGV images showing peaks identified in the ChIP-seq experiment 1 and 2 of PbAP2-FG2 on the chromosome 1. Read coverage for the ChIP data is shown. (B) IDR1D analysis between the ChIP-seq experiment 1 and 2.
Izumi Kaneko (121023) +3 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Quantifying the impact of inter-site heterogeneity on the distribution of ChIP-seq data
Frontiers in Genetics, 2014 Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) is a valuable tool for epigenetic studies. Analysis of the data arising from ChIP-seq experiments often requires implicit or explicit statistical modelling of the read counts.
Jonathan eCairns +3 more
doaj +1 more source
Nuclear RNA sequencing of the mouse erythroid cell transcriptome [PDF]
, 2012 Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Umlauf David +39 more
core +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
MutiQC Report for Neuroblastoma Cell Line ATAC-Seq and ChIP-Seq
, 2020 MutiQC Report for Neuroblastoma Cell Line ATAC-Seq and ChIP ...
Apexa Modi (8526572) +1 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
xcore: an R package for inference of gene expression regulators
BMC Bioinformatics, 2023 Background Elucidating the Transcription Factors (TFs) that drive the gene expression changes in a given experiment is a common question asked by researchers.
Maciej Migdał +7 more
doaj +1 more source
Wellington : a novel method for the accurate identification of digital genomic footprints from DNase-seq data [PDF]
, 2013 The expression of eukaryotic genes is regulated by cis-regulatory elements such as promoters and enhancers, which bind sequence-specific DNA-binding proteins.
Bonifer, Constanze +8 more
core +1 more source