Results 71 to 80 of about 574,514 (257)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
7C: Computational Chromosome Conformation Capture by Correlation of ChIP-seq at CTCF motifs
BMC Genomics, 2019 Background Knowledge of the three-dimensional structure of the genome is necessary to understand how gene expression is regulated. Recent experimental techniques such as Hi-C or ChIA-PET measure long-range chromatin interactions genome-wide but are ...
Jonas Ibn-Salem +1 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
RACS: rapid analysis of ChIP-Seq data for contig based genomes
BMC Bioinformatics, 2019 Background Chromatin immunoprecipitation coupled to next generation sequencing (ChIP-Seq) is a widely-used molecular method to investigate the function of chromatin-related proteins by identifying their associated DNA sequences on a genomic scale.
Alejandro Saettone +3 more
doaj +1 more source
vanrooij-lab/chip-seq-pipeline2: chip-seq-pipeline2
<p>chip-seq-pipeline2</p ...
Jin wook Lee, Soo Lee, J. Seth Strattan
core +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
In silico pooling of ChIP-seq control experiments.
PLoS ONE, 2014 As next generation sequencing technologies are becoming more economical, large-scale ChIP-seq studies are enabling the investigation of the roles of transcription factor binding and epigenome on phenotypic variation.
Guannan Sun +5 more
doaj +1 more source
ChIP-chip versus ChIP-seq: Lessons for experimental design and data analysis
BMC Genomics, 2011 Background Chromatin immunoprecipitation (ChIP) followed by microarray hybridization (ChIP-chip) or high-throughput sequencing (ChIP-seq) allows genome-wide discovery of protein-DNA interactions such as transcription factor bindings and histone ...
Karchenko Peter V +5 more
doaj +1 more source
ChIP-Seq of ZmSNAC1, ZmNAC23 and ZmNAC20
, 2019 To explore the function of ZmSNAC1, ZmNAC23 and ZmNAC20 in salt stress resistance and plant development, the downstream target genes were explored by ChIP-Seq with ZmNACs-GFP transgenic maize plants (pooled leaves and roots at V1 stage)
can liu (4453648)
core +1 more source