Results 71 to 80 of about 574,745 (303)

ChIP-seq analysis using PbAP2-FG2::GFP.

, 2023
(A) IGV images showing peaks identified in the ChIP-seq experiment 1 and 2 of PbAP2-FG2 on the chromosome 1. Read coverage for the ChIP data is shown. (B) IDR1D analysis between the ChIP-seq experiment 1 and 2.
Izumi Kaneko (121023), Shiroh Iwanaga (121019), Tsubasa Nishi (12133480), Masao Yuda (70356)   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Nuclear RNA sequencing of the mouse erythroid cell transcriptome [PDF]

, 2012
Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Umlauf David, Catherine A. Moir (115926), Chakalova, L, Peter Fraser, Eskiw, CH, Mitchell, JA, Fraser, P, Mitchell Jennifer A., Schoenfelder, S, Umlauf, D, Clay Ieuan, Chakalova Lyubomira, David Umlauf (115924), Ieuan Clay, Jennifer A. Mitchell (32136), Schoenfelder Stefan, Chih-Yu Chen, Eskiw Christopher H., Stefan Schoenfelder, Ieuan Clay (115922), Chih-yu Chen (4730856), Fraser Peter, Takashi Nagano, Christopher H. Eskiw (115928), Takashi Nagano (115932), Christopher H Eskiw, Nagano Takashi, Lyubomira Chakalova, Nagano, T, Peter Fraser (32141), Stefan Schoenfelder (115930), Chen, CY, Moir, CA, Lyubomira Chakalova (23035), Chen Chih-yu, Jennifer A Mitchell, Clay, I, David Umlauf, Catherine A Moir, Moir Catherine A.   +39 more
core   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

MutiQC Report for Neuroblastoma Cell Line ATAC-Seq and ChIP-Seq

, 2020
MutiQC Report for Neuroblastoma Cell Line ATAC-Seq and ChIP ...
Apexa Modi (8526572), Jo Lynne Rokita (5706383)   +1 more
core   +1 more source

xcore: an R package for inference of gene expression regulators

BMC Bioinformatics, 2023
Background Elucidating the Transcription Factors (TFs) that drive the gene expression changes in a given experiment is a common question asked by researchers.
Maciej Migdał, Takahiro Arakawa, Satoshi Takizawa, Masaaki Furuno, Harukazu Suzuki, Erik Arner, Cecilia Lanny Winata, Bogumił Kaczkowski   +7 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Wellington : a novel method for the accurate identification of digital genomic footprints from DNase-seq data [PDF]

, 2013
The expression of eukaryotic genes is regulated by cis-regulatory elements such as promoters and enhancers, which bind sequence-specific DNA-binding proteins.
Bonifer, Constanze, Piper, Jason, Cockerill, Peter N., Elze, Markus C., Cockerill, Peter N, Bonifer, Constanze; id_orcid, Ott, Sascha, Elze, Markus C, Cauchy, Pierre   +8 more
core   +1 more source

An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells

STAR Protocols, 2021
Summary: Integrative analysis of next-generation sequencing data can help understand disease mechanisms. Specifically, ChIP-seq can illuminate where transcription regulators bind to regulate transcription.
Lorane Texari, Nathanael J. Spann, Ty D. Troutman, Mashito Sakai, Jason S. Seidman, Sven Heinz   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source