Results 71 to 80 of about 3,050,859 (351)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Comparison of Modulation-Assisted Machining Strategies for Achieving Chip Breakage When Turning 17-4 PH Stainless Steel

Journal of Manufacturing and Materials Processing
Chip morphology is an intrinsic characteristic of the machining process that determines the quality of the process. When machining low machinability materials, the chips formed are usually long, continuous, and difficult to break.
Ainhoa Robles, Asier Astarloa, Iñigo Llanos, Iker Mancisidor, Maria Helena Fernandes, Jokin Munoa   +5 more
doaj   +1 more source

Experimental investigation on tool life and chip morphology in hot machining of Monel-400

Engineering Science and Technology, an International Journal, 2018
In the present study, an experimental investigation has been carried out to examine the effect of heating through a gas flame in the hot turning of Monel-400.
Asit Kumar Parida, Kalipada Maity
doaj   +1 more source

Comparison of Machining Simulations of Aerospace Alloy Al6061-T6 Using Lagrangian and Smoothed Particle Hydrodynamics Techniques

Lubricants, 2022
This research focuses on the study of the simulation capabilities of the lagrangian (LAG) model and Smoothed Particle Hydrodynamics (SPH) model for the orthogonal dry machining of aluminum alloy Al6061-T6.
Muhammad N. Nawaz, Sohaib Z. Khan, Muhammad Asif, Abdulrahman Aljabri, Asad A. Zaidi, Essam R. I. Mahmoud   +5 more
doaj   +1 more source

Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes

, 2018
An important number of healthy and diseased tissues shows spatial variations in their metabolic capacities across the tissue. The liver is a prime example of such heterogeneity where the gradual changes in various metabolic activities across the liver ...
Eo, Jinsu, Kang, Young Bok (Abraham), Mert, Safak, Usta, O. Berk, Yarmush, Martin L.   +4 more
core   +2 more sources

An experimental study of the effect of high-pressure water jet assisted turning (HPWJAT) on the surface integrity [PDF]

, 2011
This study deals with the effect of High-Pressure Water Jet Assisted Turning (HPWJAT) of austenitic stainless steels on chip shape and residual stresses. The machining of the austenitic stainless steels represents several difficulties. Recently, research
HABAK, Malek, LEBRUN, Jean-Lou
core   +4 more sources

Chip Flow Direction Modeling and Chip Morphology Analysis of Ball-End Milling Cutters

Coatings
Ball-end milling cutters are normally used for complex surface machining. During the milling process, the tool posture and cutting parameters of the ball-end milling cutters have a significant impact on chip formations and morphological changes. Based on the Cutter Workpiece Engagement (CWE) model, this study establishes a chip flow model for ball-end ...
Shiqiang Zhou, Anshan Zhang, Xiaosong Zhang, Maiqi Han, Bowen Liu   +4 more
openaire   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Investigation of the effects of machining parameters on cutting conditions during orthogonal turning of austenite stainless steel

Production Engineering Archives
The 1.4306 austenite stainless steel has been prominently utilized as a material in the automotive and aerospace industry. Considerable interest has been garnered in the machinability of stainless steel owing to its high strength and poor thermal ...
Kónya Gábor, Takács János, Miskolczi István, Kovács Zsolt F.   +3 more
doaj   +2 more sources

Influence of Cutting Parameters and Tool Surface Texturing on Surface Integrity in Face Milling of AISI 1050 Carbon Steel

Journal of Manufacturing and Materials Processing
Machining of medium-carbon steels, such as AISI 1050, poses a significant challenge in terms of achieving stable cutting conditions, controlled chip evacuation and high surface integrity, in particular when full-face milling is performed under elevated ...
Serafino Caruso, Maria Rosaria Saffioti, Vincenzina Siciliani, Giulia Zaniboni, Domenico Umbrello, Leonardo Orazi, Luigino Filice   +6 more
doaj   +1 more source