Results 41 to 50 of about 205,612 (304)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Cutting Forces and Chip Morphology during Wood Plastic Composites Orthogonal Cutting

BioResources, 2014
The effect of chip thickness, rake angle, and edge radius on cutting forces and chip morphology in wood plastic composites (WPCs) orthogonal cutting was investigated.
Xiaolei Guo, Mats Ekevad, Birger Marklund, Rongrong Li, Pingxiang Cao, Anders Grönlund   +5 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Toward a better understanding of tool wear effect through a comparison between experiments and SPH numerical modelling of machining hard materials [PDF]

, 2009
The aim of this study is to improve the general understanding of tungsten carbide (WC–Co) tool wear under dry machining of the hard-to-cut titanium alloy Ti6Al4V. The chosen approach includes experimental and numerical tests.
Bil, C. Espinosa, D. Coupard, Dearnley, Dearnley, Ezugwu, Ezugwu, Ezugwu, F. Girot, Gingold, J. Limido, Karpat, Komanduri, Lee, Libersky, Limido, Lucy, M. Calamaz, M. Nouari, M. Salaün, Meyer, Monaghan, R. Chieragatti, Siekmann, Yen, Özel, Özel   +26 more
core   +7 more sources

High-Q-factor Al [subscript 2]O[subscript 3] micro-trench cavities integrated with silicon nitride waveguides on silicon [PDF]

, 2020
We report on the design and performance of high-Q integrated optical micro-trench cavities on silicon. The microcavities are co-integrated with silicon nitride bus waveguides and fabricated using wafer-scale silicon-photonics-compatible processing steps.
Adam, Thomas N., Bradley, Jonathan D. B., Coolbaugh, Douglas, Frankis, Henry C., Leake, Gerald, Li, Nanxi, Magden, Salih, Su, Zhan, Watts, Michael   +8 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Silicon sample holder for molecular beam epitaxy on pre-fabricated integrated circuits [PDF]

, 1994
The sample holder of the invention is formed of the same semiconductor crystal as the integrated circuit on which the molecular beam expitaxial process is to be performed.
Grunthaner, Frank J., Grunthaner, Paula J., Hoenk, Michael E.   +2 more
core   +1 more source

Chip Thickness and Microhardness Prediction Models during Turning of Medium Carbon Steel

Journal of Applied Mathematics, 2007
Cutting tests were conducted to medium carbon steel using HSS tools with cutting fluid. The experimental design used was based on response surface methodology (RSM) using a central composite design.
S. A. Alrabii, L. Y. Zumot
doaj   +1 more source

An Experimental Study on Mechanical Modeling of Ceramics Based on Microstructure

Applied Sciences, 2015
The actual grinding result of ceramics has not been well predicted by the present mechanical models. No allowance is made for direct effects of materials microstructure and almost all the mechanical models were obtained based on crystalline ceramics.
Ya-Nan Zhang, Bin Lin, Jian-Jun Liu, Xiao-Fei Song, Jie Yang Key   +4 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source