Results 91 to 100 of about 1,171,988 (336)

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Will the real specialist please stand up? Characterising early craft specialisation, a comparative approach for Neolithic Anatolia

Documenta Praehistorica, 2013
The Neolithic period saw changes in production practices and the roles of individuals that were important in the development of increasing social differentiation.
Emma Baysal
doaj   +1 more source

Lithics in the Neolithic archaeology of Greece: Capturing the social dynamics of chipped stone technology.

, 2015
Over the years, lithic analysis has become an integral part of Neolithic research in Greece. In the past, chipped stone tools were considered as potential chronological and cultural markers.
Odysseas Kakavakis
semanticscholar   +1 more source

2016 Archaeological Investigations at the T. M. Sanders Site (41LR2), Lamar County, Texas [PDF]

, 2017
On March 4th and 5th, 2016, Bo Nelson and Mark Walters returned to the T. M. Sanders site (41LR2) to inspect the property after Julia Trigg Crawford, the main landowner of the site, informed us that the fields at the site had been prepped for this year ...
Nelson, Bo, Perttula, Timothy K., Walters, Mark   +2 more
core   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Flint assemblages in the context of cultural transition during the 6th millennium BC: a case study from Bulgaria

Българско е-Списание за Археология, 2018
This paper offers a general overview of the chipped stone assemblages from Bulgaria during the Neolithic period (6th millennium BC). Based on numerous flint assemblages belonging to different phases of the Neolithic (many of them studied by the author ...
Maria Gurova
doaj  

The Organization of Novaculite Tool Production: Quarry-Workshop Debitage Comparisons [PDF]

, 2007
Arkansas novaculite, outcropping in the Ouachita Mountains of Arkansas and Oklahoma, has been an important regional lithic resource for thousands of years.
Trubitt, Mary Beth D.
core   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

The Norman Site Excavations Near Wagoner, Oklahoma [PDF]

, 2000
The Norman site is seven miles southeast of Wagoner, Wagoner County, Okla., on State Highway 51. It is on the upper terraces on the west side of Grand River just north of the approach to the new bridge. Principal mound is a double unit; the larger mound,
Finkelstein, J. Joe
core   +1 more source