Results 51 to 60 of about 2,645,891 (207)

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Chipped Stone Tools Database

Spreadsheet data of chipped stone tools at K'axob.
McAnany, Patricia A.
core   +1 more source

Phase‐Dependent Oxygen Defect Energetics in Epitaxial NbN/AlN/NbN Films

Advanced Science, EarlyView.
Phase dependent oxygen defect energetics in epitaxial δ‐NbN/AlN/δ‐NbN and β‐Nb2N/AlN/β‐Nb2N trilayers. Atomic‐scale analysis and first‐principles calculations reveal distinct oxygen incorporation pathways across NbN polymorphs. Layer resolved defect formation energies show that O is energetically more favorable within δ‐NbN electrodes, whereas in β ...
Prachi Garg, Kedarsh Kaushik, Danqing Wang, Naomi Pieczulewski, Anand Ithepalli, John Wright, Debdeep Jena, David A. Muller, Hong X. Tang, Cyrus Dreyer, Baishakhi Mazumder   +10 more
wiley   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Preliminary Evaluations of the Bilecik Bahcelievler Neolithic Chipped Stone Assemblage

, 2021
This paper details the preliminary results of the chipped stone artifacts from the Bahcelievler settlement, uncovered during the 2019 and 2020 excavation seasons, which were directed by the Bilecik Archaeology Museum.
Fidan, Erkan, Kolankaya-Bostanci, Neyir
core   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Koncepcja krzemieniarstwa schyłkowego na przykładzie eneolitu Moraw

Przegląd Archeologiczny, 2012
The concept of Terminal Lithic Industries has been developed as a result of a century-long interest of Polish archaeologists in chipped stone materials from the turn of Stone and Bronze Ages.
Jerzy Kopacz
doaj  

Responsive Open Microfluidic Logic for Mechanical Computing

Advanced Science, EarlyView.
Coupling elasticity with capillarity transforms mechanical compression into binary fluidic states, enabling deterministic logic in open microfluidic circuits. This work demonstrates that computation can emerge from interactions between mechanic and fluidic domains, establishing a general strategy for embedding information processing directly within ...
Roi Almog, Bat‐El Pinchasik
wiley   +1 more source

Chipped stone technological organization central place foraging and exchange on the Northern Great Plains

, 2019
"Combines a vast array of data with evolutionary ecology to define patterns in how past peoples along the Missouri River used stone sources for crafting tools."--Provided by ...
Johnson, Craig M.
core  

Small tools within Mode 2 technology in the Lower Palaeolithic of Italy: use-wear analysis of the chipped stone tools assemblage of the Latium site of Fontana Ranuccio (Italy)

IpoTESI di Preistoria, 2019
Recent technological studies of lithic assemblages from Levantine and European Late Lower Palaeolithic showed that the small size flakes (small tools) found in many sites of this period are relevant technological elements.
Flavia Marinelli, Cristina Lemorini, Daniela Zampetti   +2 more
doaj   +1 more source