Results 61 to 70 of about 2,645,891 (207)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung   +15 more
wiley   +1 more source

Flint assemblages in the context of cultural transition during the 6th millennium BC: a case study from Bulgaria

open access: yesБългарско е-Списание за Археология, 2018
This paper offers a general overview of the chipped stone assemblages from Bulgaria during the Neolithic period (6th millennium BC). Based on numerous flint assemblages belonging to different phases of the Neolithic (many of them studied by the author ...
Maria Gurova
doaj  

The Challenge of Characterising Large Assemblages of Exotic Materials: a case study of the obsidian from Domuztepe, SE Turkey

open access: yesInternet Archaeology, 2009
Obsidian artefacts from Domuztepe (a large late Neolithic site in the Kahramanmaraş plain in south-east Turkey belonging to the Halaf culture and dated to c. 6000-5500 cal.
Elizabeth Healey , Stuart Campbell
doaj   +1 more source

Automated Alignment Powered by Computer Vision Streamlines the Two‐Photon Polymerization‐Based Micro 3D Printing of Multiscale and Multimaterial Structures

open access: yesAdvanced Intelligent Discovery, EarlyView.
Two‐photon polymerization enables high‐resolution microfabrication, but performing alignment when printing multiple structures is difficult. Here, we present a fast, robust, and open‐source protocol for automated alignment on Nanoscribe systems. Achieving ≈0.4 μm accuracy in under 5 s, our protocol reduces time and error in multimaterial printing. This
Daniel Maher   +4 more
wiley   +1 more source

The Impact of Mobility on a Chipped Stone Assemblage in the Bootheel Region of New Mexico

open access: yes, 2023
The author has granted permission for their work to be available to the general public.This thesis examines the impact that mobility had on the chipped stone assemblage at the Late Archaic Tom Holcomb site (LA 162023) in the Bootheel region of New Mexico.
Wendel, Steven P.
core  

Aşezarea cucuteniană de la Cucuteni - Dealul Mănăstirii / La Dobrin

open access: yesArheologia Moldovei, 2017
The Cucutenian Settlement of Cucuteni - Dealul Mânăstirii / La Dobrin Archaeological excavations at Dealul Mănăstirii / La Dobrin (1979-1981) attest to the existence of a secondary settlement (based on quality, shapes and decoration of thepottery ...
Cornelia-Magda Lazarovici
doaj   +1 more source

Note on a Possible Chipped Stone Grubbing Tool from Upshur County, Texas

open access: yesIndex of Texas Archaeology Open Access Grey Literature from the Lone Star State, 2005
During the period August 6-27, and November 18-20, 2003, archeologists from Geo-Marine Inc. (GMI), of Plano, Texas, conducted a pedestrian survey of a 51.5 km-long corridor for the proposed Southside Regional Water System in Marion, Harrison, Upshur, and Gregg counties, Texas.
Lintz, Christopher, Largent, Floyd
openaire   +3 more sources

Prospecting of Architectural Features Using LiDAR‐UAV Technology, Deep Neural Networks and Visualization Techniques: A Case Study in Kuélap and Cambolín (NW Peru)

open access: yesArchaeological Prospection, EarlyView.
ABSTRACT High‐resolution and accurate synoptic images of terrestrial topography, even in densely forested areas, have proven valuable for archaeology by enabling the identification and characterization of relief patterns associated with ancient human activities. This study presents a novel approach that integrates digital terrain models (DTMs) obtained
Jhon A. Zabaleta‐Santisteban   +13 more
wiley   +1 more source

Biomineralization of primary carbonate cements: a new biosignature in the fossil record from the Anisian of Southern Italy

open access: yesLethaia, EarlyView., 2021
Biomineralization is a generic term used to indicate biological‐mediated mineral formation. In carbonate mineralization, nucleation of crystals can be: (1) controlled directly by the organisms, like in the skeletal formation of most metazoans; (2) induced by microbial communities, by indirect precipitation mediated by their metabolic activities; or (3)
Adriano Guido   +4 more
wiley   +1 more source

In terms of morphological typology Carchemish Dam Lake area chipped stone industry

open access: yes, 2021
This study was created by typologically examining and defining the chipped stone industry found in the Carcamesh Dam Lake Area as part of the "Rescue of Archaeological and Cultural Heritage Under the Ilısu and Carcamesh Dam Lakes Archaeological and ...
Bal, Burcu Cemre
core  

Home - About - Disclaimer - Privacy