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The Pathology of Chironex fleckeri Venom and Known Biological Mechanisms [PDF]

open access: yesToxicon: X, 2020
The large box jellyfish Chironex fleckeri is found in northern Australian waters. A sting from this cubozoan species can kill within minutes. From clinical and animal studies, symptoms comprise severe pain, welts, scarring, hypotension, vasospasms ...
John Miles, Yide Wong, Alan J Nimmo
exaly   +7 more sources

Venom proteome of the box jellyfish Chironex fleckeri. [PDF]

open access: yesPLoS ONE, 2012
The nematocyst is a complex intracellular structure unique to Cnidaria. When triggered to discharge, the nematocyst explosively releases a long spiny, tubule that delivers an often highly venomous mixture of components.
Diane L Brinkman   +5 more
doaj   +7 more sources

Cardiotoxic Effects of Venoms From Chironex fleckeri and Chiropsalmus sp. on an Invertebrate Model [PDF]

open access: yesJournal of Venomous Animals and Toxins Including Tropical Diseases, 2006
Extracted venoms from two species of cubozoan, Chironex fleckeri (C. fleckeri)and Chiropsalmus sp., were injected into the freshwater crayfish Cherax quadricarinatus (C. quadricarinatus).
Jamie Seymour
exaly   +4 more sources

Structural Characterisation of Predicted Helical Regions in the Chironex fleckeri CfTX-1 Toxin [PDF]

open access: yesMarine Drugs, 2018
The Australian jellyfish Chironex fleckeri, belongs to a family of cubozoan jellyfish known for their potent venoms. CfTX-1 and -2 are two highly abundant toxins in the venom, but there is no structural data available for these proteins.
Michael Smout, Norelle L Daly
exaly   +4 more sources

Validation of eDNA as a viable method of detection for dangerous cubozoan jellyfish

open access: yesEnvironmental DNA, 2021
Stings from certain species of cubozoan jellyfish are dangerous to humans and their seasonal presence in tropical marine waters poses a significant risk to coastal communities.
Brett Bolte   +4 more
doaj   +2 more sources

Firing the Sting: Chemically Induced Discharge of Cnidae Reveals Novel Proteins and Peptides From Box Jellyfish (Chironex fleckeri) Venom

open access: yesToxins, 2015
Cnidarian venom research has lagged behind other toxinological fields due to technical difficulties in recovery of the complex venom from the microscopic nematocysts.
Timothy Jackson   +2 more
exaly   +3 more sources

Cloning and Expression of N-CFTX-1 Antigen from Chironex fleckeri in Escherichia coli and Determination of Immunogenicity in Mice

open access: yesIranian Journal of Public Health, 2021
Background: Most jellyfish species are poisonous. Human victims of jellyfish sting each year are 120 million. Chironex fleckeri is a venomous box jellyfish that inflicts painful and potentially fatal stings to humans.
Hossein JAFARI   +5 more
doaj   +1 more source

Cubozoan venom-induced cardiovascular collapse is caused by hyperkalemia and prevented by zinc gluconate in mice. [PDF]

open access: yesPLoS ONE, 2012
Chironex fleckeri (Australian box jellyfish) stings can cause acute cardiovascular collapse and death. We developed methods to recover venom with high specific activity, and evaluated the effects of both total venom and constituent porins at doses ...
Angel A Yanagihara, Ralph V Shohet
doaj   +1 more source

Investigation of Best Practices for Venom Toxin Purification in Jellyfish towards Functional Characterisation

open access: yesToxins, 2023
The relative lack of marine venom pharmaceuticals can be anecdotally attributed to difficulties in working with venomous marine animals, including how to maintain venom bioactivity during extraction and purification.
Blake Lausen   +3 more
doaj   +1 more source

Genetic Detection and a Method to Study the Ecology of Deadly Cubozoan Jellyfish

open access: yesDiversity, 2022
Cubozoan jellyfish pose a risk of envenomation to humans and a threat to many businesses, yet crucial gaps exist in determining threats to stakeholders and understanding their ecology.
Scott J. Morrissey   +2 more
doaj   +1 more source

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