Results 11 to 20 of about 254 (135)

Successful heart transplant in a child with congenital core myopathy and delayed‐onset restrictive cardiomyopathy due to recessive mutations in the titin (TTN) gene

Pediatric Transplantation, Volume 27, Issue 6, September 2023., 2023
Abstract Background Mutations in the TTN gene, encoding the muscle filament titin, are a major cause of inherited dilated cardiomyopathy. Early‐onset skeletal muscle disorders due to recessive TTN mutations have recently been described, sometimes associated with cardiomyopathies.
Julie Wacker, Stefano Di Bernardo, Johannes Alexander Lobrinus, Heinz Jungbluth, Mathias Gautel, Maurice Beghetti, Joel Fluss   +6 more
wiley   +1 more source

Pediatric Population Pharmacokinetic Modeling and Exposure–Response Analysis of Ambrisentan in Pulmonary Arterial Hypertension and Comparison With Adult Data

The Journal of Clinical Pharmacology, Volume 63, Issue 5, Page 593-603, May 2023., 2023
Abstract This study aimed to develop a population pharmacokinetic (PK) model of ambrisentan in pediatric patients (8 to <18 years) with pulmonary arterial hypertension (PAH) and compare pediatric ambrisentan systemic exposure with previously reported adult data.
Malek Okour, Mita M. Thapar, Colm Farrell, Mary Ann Lukas, Maurice Beghetti, Misba Beerahee   +5 more
wiley   +1 more source

Sequencing and titrating approach of therapy in heart failure with reduced ejection fraction following the 2021 European Society of Cardiology guidelines: an international cardiology survey

European Journal of Heart Failure, Volume 25, Issue 2, Page 213-222, February 2023., 2023
The latest European guidelines for heart failure with reduced ejection fraction (HFrEF) patients recommend initiating four major therapeutic classes rather than the sequential initiation from the previous guidelines. Without any evidence from randomized controlled trials, the perception and the practical approach to these guidelines by practicing ...
Charles Fauvel, Guillaume Bonnet, Wilfried Mullens, Clara Ines Saldarriaga Giraldo, Anja Zupan Mežnar, Anders Barasa, Mariya Tokmakova, Anastasia Shchendrygina, Francisco Moscoso Costa, Massimo Mapelli, Filip Zemrak, Laurens F. Tops, Nina Jakus, Arian Sultan, Fadel Bahouth, Chahr‐eddine Hadjseyd, Muriel Salvat, Matteo Anselmino, Daniel Messroghli, Vanessa Weberndörfer, Ilya Giverts, Thomas Bochaton, Pierre Yves Courand, Emmanuelle Berthelot, Damien Legallois, Florence Beauvais, Fabrice Bauer, Nicolas Lamblin, Thibaud Damy, Nicolas Girerd, Laurent Sebbag, Théo Pezel, Alain Cohen‐Solal, Giuseppe Rosano, François Roubille, Nathan Mewton   +35 more
wiley   +1 more source

Micra AV leadless pacemaker implantation after transcatheter aortic valve implantation

Pacing and Clinical Electrophysiology, Volume 45, Issue 11, Page 1310-1315, November 2022., 2022
Abstract Background Transvenous pacemaker (PM) implantation is a complication in patients undergoing transcatheter aortic valve implantation (TAVI). Recently, a second generation of leadless PMs able of atrioventricular (AV) synchronous pacing has been introduced and could be an alternative when ventricular pacing is required after TAVI.
Alexis Mechulan, Sébastien Prevot, Angélique Peret, Lyassine Nait‐Saidi, Ichem Miliani, Lauriane Leong‐Feng, Elisabeth Leude‐Vaillant, Alain Vaillant, Alain Cornen, Bernard Latiere, Marie‐Paule Giacomoni, Frédéric Collet, Vincent Bechet, Ahmed Bouharaoua, Pierre Dieuzaide   +14 more
wiley   +1 more source

Riociguat in children with pulmonary arterial hypertension: The PATENT–CHILD study

Pulmonary Circulation, Volume 12, Issue 3, July 2022., 2022
Abstract Riociguat, a soluble guanylate cyclase stimulator, is approved for treatment of adults with pulmonary arterial hypertension (PAH). The safety, tolerability, and pharmacokinetics (PK) of oral riociguat in a pediatric population with PAH was assessed in PATENT–CHILD (NCT02562235), a multicenter, single‐arm, 24‐week, open‐label, Phase 3 study ...
Humberto García Aguilar, Matthias Gorenflo, D. Dunbar Ivy, Shahin Moledina, Biagio Castaldi, Hidekazu Ishida, Paweł Cześniewicz, Jacek Kusa, Oliver Miera, Joseph Pattathu, Ken‐Pen Weng, Laszlo Ablonczy, Christian Apitz, Marta Katona, Kenichi Kurosaki, Tomas Pulido, Hiroyuki Yamagishi, Kazushi Yasuda, Galia Cisternas, Melanie Goth, Susanne Lippert, Anna Radomskyj, Soundos Saleh, Stefan Willmann, Gabriela Wirsching, Damien Bonnet, Maurice Beghetti   +26 more
wiley   +1 more source

Body composition and maximal exercise capacity after heart transplantation

ESC Heart Failure, Volume 9, Issue 1, Page 122-132, February 2022., 2022
Abstract Aims Maximal exercise capacity as measured by peak oxygen consumption (pVO2) in cardiopulmonary exercise testing (CPET) of heart transplant recipients (HTR) is limited to a 50–70% level of healthy age‐matched controls. This study investigated the relationship between body composition and pVO2 during the first decade post‐transplant.
Julien Regamey, Pierre Monney, Patrick Yerly, Lucie Favre, Matthias Kirsch, Piergiorgio Tozzi, Olivier Lamy, Roger Hullin   +7 more
wiley   +1 more source

Haemodynamic parameters associated with renal function prior to and following heart transplantation

ESC Heart Failure, Volume 8, Issue 6, Page 4944-4954, December 2021., 2021
Abstract Aims Abnormal renal function is a common feature in patients on heart transplant waiting lists. This study aimed to identify the haemodynamic parameters associated with decreased estimated glomerular filtration rate (eGFR) in patients listed for heart transplantation (HT) and renal function improvement following HT. Methods and results A total
Guillaume Baudry, Laurent Sebbag, Juliette Bourdin, Elisabeth Hugon‐Vallet, Antoine Jobbe Duval, Nathan Mewton, Matteo Pozzi, Patrick Rossignol, Nicolas Girerd   +8 more
wiley   +1 more source

Study design and rationale of the pAtients pResenTing with cOngenital heaRt dIseAse Register (ARTORIA‐R)

ESC Heart Failure, Volume 8, Issue 6, Page 5542-5550, December 2021., 2021
Abstract Aim Due to improved therapy in childhood, many patients with congenital heart disease reach adulthood and are termed adults with congenital heart disease (ACHD). ACHD often develop heart failure (HF) as a consequence of initial palliative surgery or complex anatomy and subsequently require advanced HF therapy.
Christoph Sinning, Elvin Zengin, Gerhard‐Paul Diller, Francesco Onorati, María‐Angeles Castel, Thibault Petit, Yih‐Sharng Chen, Mauro Lo Rito, Carmelina Chiarello, Romain Guillemain, Karine Nubret‐Le Coniat, Christina Magnussen, Dorit Knappe, Peter Moritz Becher, Benedikt Schrage, Jacqueline M. Smits, Andreas Metzner, Christoph Knosalla, Felix Schoenrath, Oliver Miera, Mi‐Young Cho, Alexander Bernhardt, Jessica Weimann, Alina Goßling, Amedeo Terzi, Antonio Amodeo, Sara Alfieri, Emanuela Angeli, Luca Ragni, Carlo Pace Napoleone, Gino Gerosa, Nicola Pradegan, Inez Rodrigus, Julia Dumfarth, Michel de Pauw, Katrien François, Olivier Van Caenegem, Arnaut Ancion, Johan Van Cleemput, Davor Miličić, Ajay Moza, Peter Schenker, Josef Thul, Michael Steinmetz, Gregor Warnecke, Fabio Ius, Susanne Freyt, Murat Avsar, Tim Sandhaus, Assad Haneya, Sandra Eifert, Diyar Saeed, Michael Borger, Henryk Welp, László Ablonczy, Bastian Schmack, Arjang Ruhparwar, Shiho Naito, Xiaoqin Hua, Nina Fluschnik, Moritz Nies, Laura Keil, Juliana Senftinger, Djemail Ismaili, Shinwan Kany, Dora Csengeri, Massimo Cardillo, Alessandra Oliveti, Giuseppe Faggian, Richard Dorent, Carine Jasseron, Alicia Pérez Blanco, José Manuel Sobrino Márquez, Raquel López‐Vilella, Ana García‐Álvarez, María Luz Polo López, Alvaro Gonzalez Rocafort, Óscar González Fernández, Raquel Prieto‐Arevalo, Eduardo Zatarain‐Nicolás, Katrien Blanchart, Aude Boignard, Pascal Battistella, Soulef Guendouz, Lucile Houyel, Marylou Para, Erwan Flecher, Arnaud Gay, Éric Épailly, Camille Dambrin, Kaitlyn Lam, Cally Ho Ka‐lai, Yang Hyun Cho, Jin‐Oh Choi, Jae‐Joong Kim, Louise Coats, David Steven Crossland, Lisa Mumford, Samer Hakmi, Cumaraswamy Sivathasan, Larissa Fabritz, Stephan Schubert, Jan Gummert, Michael Hübler, Peter Jacksch, Andreas Zuckermann, Günther Laufer, Helmut Baumgartner, Alessandro Giamberti, Hermann Reichenspurner, Paulus Kirchhof   +110 more
wiley   +1 more source

A +3 variant at a donor splice site leads to a skipping of the MYH11 exon 32, a recurrent RNA defect causing Heritable Thoracic Aortic Aneurysm and Dissection and/or Patent Ductus Arteriosus

Molecular Genetics &Genomic Medicine, Volume 9, Issue 11, November 2021., 2021
We report on a family with heritable thoracic aortic aneurysm and/or dissection with patent ductus arteriosus (FTAAD/PDA) caused by a variant leading to a skipping of the exon 32 in the MYH11 gene. This transcripts defect previously shown to lead to a strong dominant negative effect in the smooth muscle myosin rod is recurrent.
Bertrand Chesneau, Aurélie Plancke, Guillaume Rolland, Bertrand Marcheix, Yves Dulac, Thomas Edouard, Julie Plaisancié, Marion Aubert‐Mucca, Sophie Julia, Maud Langeois, Thierry Lavabre‐Bertrand, Philippe Khau Van Kien   +11 more
wiley   +1 more source

Acute effects of hypouricemia on endothelium, oxidative stress, and arterial stiffness: A randomized, double‐blind, crossover study

Physiological Reports, Volume 9, Issue 17, September 2021., 2021
Acute moderate hypouricemia encompasses minor improvements in endothelial function, blood pressure, and arterial stiffness. Abstract We hypothesized acute moderate and drastic reductions in uric acid concentration exert different effects on arterial function in healthy normotensive and hypertensive adults. Thirty‐six adults (aged 58 [55;63] years) with
Benjamin De Becker, Emeline Hupkens, Laurence Dewachter, Catherine Coremans, Cédric Delporte, Pierre van Antwerpen, Thierry Franck, Karim Zouaoui Boudjeltia, Pierre Cullus, Philippe van de Borne   +9 more
wiley   +1 more source