Results 21 to 30 of about 1,580 (177)

Riociguat in children with pulmonary arterial hypertension: The PATENT–CHILD study

Pulmonary Circulation, Volume 12, Issue 3, July 2022., 2022
Abstract Riociguat, a soluble guanylate cyclase stimulator, is approved for treatment of adults with pulmonary arterial hypertension (PAH). The safety, tolerability, and pharmacokinetics (PK) of oral riociguat in a pediatric population with PAH was assessed in PATENT–CHILD (NCT02562235), a multicenter, single‐arm, 24‐week, open‐label, Phase 3 study ...
Humberto García Aguilar, Matthias Gorenflo, D. Dunbar Ivy, Shahin Moledina, Biagio Castaldi, Hidekazu Ishida, Paweł Cześniewicz, Jacek Kusa, Oliver Miera, Joseph Pattathu, Ken‐Pen Weng, Laszlo Ablonczy, Christian Apitz, Marta Katona, Kenichi Kurosaki, Tomas Pulido, Hiroyuki Yamagishi, Kazushi Yasuda, Galia Cisternas, Melanie Goth, Susanne Lippert, Anna Radomskyj, Soundos Saleh, Stefan Willmann, Gabriela Wirsching, Damien Bonnet, Maurice Beghetti   +26 more
wiley   +1 more source

Body composition and maximal exercise capacity after heart transplantation

ESC Heart Failure, Volume 9, Issue 1, Page 122-132, February 2022., 2022
Abstract Aims Maximal exercise capacity as measured by peak oxygen consumption (pVO2) in cardiopulmonary exercise testing (CPET) of heart transplant recipients (HTR) is limited to a 50–70% level of healthy age‐matched controls. This study investigated the relationship between body composition and pVO2 during the first decade post‐transplant.
Julien Regamey, Pierre Monney, Patrick Yerly, Lucie Favre, Matthias Kirsch, Piergiorgio Tozzi, Olivier Lamy, Roger Hullin   +7 more
wiley   +1 more source

Haemodynamic parameters associated with renal function prior to and following heart transplantation

ESC Heart Failure, Volume 8, Issue 6, Page 4944-4954, December 2021., 2021
Abstract Aims Abnormal renal function is a common feature in patients on heart transplant waiting lists. This study aimed to identify the haemodynamic parameters associated with decreased estimated glomerular filtration rate (eGFR) in patients listed for heart transplantation (HT) and renal function improvement following HT. Methods and results A total
Guillaume Baudry, Laurent Sebbag, Juliette Bourdin, Elisabeth Hugon‐Vallet, Antoine Jobbe Duval, Nathan Mewton, Matteo Pozzi, Patrick Rossignol, Nicolas Girerd   +8 more
wiley   +1 more source

Severe Haemoptysis due to Pulmonary Artery Agenesis, About Two Rare but Threatening Case Reports. [PDF]

Respirol Case Rep
Unilateral pulmonary artery agenesis (UPAA) is a rare condition that may be asymptomatic or present with recurrent infections and haemoptysis. Here, we report two distinct cases of UPAA admitted for the management of haemoptysis. These two cases highlight the varied presentations and diagnostic circumstances of UPAA.
Gueçamburu M, Toublanc AC, Montaudon M, Jougon J, Grassion L, Bégueret H, Zysman M, Maurac A.   +7 more
europepmc   +2 more sources

Study design and rationale of the pAtients pResenTing with cOngenital heaRt dIseAse Register (ARTORIA‐R)

ESC Heart Failure, Volume 8, Issue 6, Page 5542-5550, December 2021., 2021
Abstract Aim Due to improved therapy in childhood, many patients with congenital heart disease reach adulthood and are termed adults with congenital heart disease (ACHD). ACHD often develop heart failure (HF) as a consequence of initial palliative surgery or complex anatomy and subsequently require advanced HF therapy.
Christoph Sinning, Elvin Zengin, Gerhard‐Paul Diller, Francesco Onorati, María‐Angeles Castel, Thibault Petit, Yih‐Sharng Chen, Mauro Lo Rito, Carmelina Chiarello, Romain Guillemain, Karine Nubret‐Le Coniat, Christina Magnussen, Dorit Knappe, Peter Moritz Becher, Benedikt Schrage, Jacqueline M. Smits, Andreas Metzner, Christoph Knosalla, Felix Schoenrath, Oliver Miera, Mi‐Young Cho, Alexander Bernhardt, Jessica Weimann, Alina Goßling, Amedeo Terzi, Antonio Amodeo, Sara Alfieri, Emanuela Angeli, Luca Ragni, Carlo Pace Napoleone, Gino Gerosa, Nicola Pradegan, Inez Rodrigus, Julia Dumfarth, Michel de Pauw, Katrien François, Olivier Van Caenegem, Arnaut Ancion, Johan Van Cleemput, Davor Miličić, Ajay Moza, Peter Schenker, Josef Thul, Michael Steinmetz, Gregor Warnecke, Fabio Ius, Susanne Freyt, Murat Avsar, Tim Sandhaus, Assad Haneya, Sandra Eifert, Diyar Saeed, Michael Borger, Henryk Welp, László Ablonczy, Bastian Schmack, Arjang Ruhparwar, Shiho Naito, Xiaoqin Hua, Nina Fluschnik, Moritz Nies, Laura Keil, Juliana Senftinger, Djemail Ismaili, Shinwan Kany, Dora Csengeri, Massimo Cardillo, Alessandra Oliveti, Giuseppe Faggian, Richard Dorent, Carine Jasseron, Alicia Pérez Blanco, José Manuel Sobrino Márquez, Raquel López‐Vilella, Ana García‐Álvarez, María Luz Polo López, Alvaro Gonzalez Rocafort, Óscar González Fernández, Raquel Prieto‐Arevalo, Eduardo Zatarain‐Nicolás, Katrien Blanchart, Aude Boignard, Pascal Battistella, Soulef Guendouz, Lucile Houyel, Marylou Para, Erwan Flecher, Arnaud Gay, Éric Épailly, Camille Dambrin, Kaitlyn Lam, Cally Ho Ka‐lai, Yang Hyun Cho, Jin‐Oh Choi, Jae‐Joong Kim, Louise Coats, David Steven Crossland, Lisa Mumford, Samer Hakmi, Cumaraswamy Sivathasan, Larissa Fabritz, Stephan Schubert, Jan Gummert, Michael Hübler, Peter Jacksch, Andreas Zuckermann, Günther Laufer, Helmut Baumgartner, Alessandro Giamberti, Hermann Reichenspurner, Paulus Kirchhof   +110 more
wiley   +1 more source

Opening the “Black Box” for Canadian Cardiac Surgery Residency Applicants∗

CJC Open, 2022
Background: This study reports on the main criteria used by Canadian cardiac surgery residency program committees (RPCs) to select applicants and the perceptions of Canadian medical students interested in cardiac surgery.
Klaudiusz Stoklosa, MD, Amine Mazine, MD, Keir A. Forgie, MD, Amy Brown, MD, MSc, Ali Hage, MD, MPH, Khalid Ridwan, MD, MSc, Charles Laurin, MD, MSc, Jessica G.Y. Luc, MD, Bobby Yanagawa, MD, PhD, Terrence M. Yau, MD, MSc   +9 more
doaj   +1 more source

A +3 variant at a donor splice site leads to a skipping of the MYH11 exon 32, a recurrent RNA defect causing Heritable Thoracic Aortic Aneurysm and Dissection and/or Patent Ductus Arteriosus

Molecular Genetics &Genomic Medicine, Volume 9, Issue 11, November 2021., 2021
We report on a family with heritable thoracic aortic aneurysm and/or dissection with patent ductus arteriosus (FTAAD/PDA) caused by a variant leading to a skipping of the exon 32 in the MYH11 gene. This transcripts defect previously shown to lead to a strong dominant negative effect in the smooth muscle myosin rod is recurrent.
Bertrand Chesneau, Aurélie Plancke, Guillaume Rolland, Bertrand Marcheix, Yves Dulac, Thomas Edouard, Julie Plaisancié, Marion Aubert‐Mucca, Sophie Julia, Maud Langeois, Thierry Lavabre‐Bertrand, Philippe Khau Van Kien   +11 more
wiley   +1 more source

Acute effects of hypouricemia on endothelium, oxidative stress, and arterial stiffness: A randomized, double‐blind, crossover study

Physiological Reports, Volume 9, Issue 17, September 2021., 2021
Acute moderate hypouricemia encompasses minor improvements in endothelial function, blood pressure, and arterial stiffness. Abstract We hypothesized acute moderate and drastic reductions in uric acid concentration exert different effects on arterial function in healthy normotensive and hypertensive adults. Thirty‐six adults (aged 58 [55;63] years) with
Benjamin De Becker, Emeline Hupkens, Laurence Dewachter, Catherine Coremans, Cédric Delporte, Pierre van Antwerpen, Thierry Franck, Karim Zouaoui Boudjeltia, Pierre Cullus, Philippe van de Borne   +9 more
wiley   +1 more source

The myosin activator omecamtiv mecarbil improves wall stress in a rat model of chronic aortic regurgitation

Physiological Reports, Volume 9, Issue 16, August 2021., 2021
Aortic regurgitation increase left ventricle wall stress, the objective of this study is to evaluate the effects of omecamtiv mecarbil on left ventricle wall stress. Abstract In patients with chronic aortic regurgitation (AR), excessive preload and afterload increase left ventricle wall stress, leading to left ventricular systolic dysfunction.
Bachar El Oumeiri, Philippe van de Borne, Géraldine Hubesch, Antoine Herpain, Filippo Annoni, Pascale Jespers, Constantin Stefanidis, Kathleen Mc Entee, Frédéric Vanden Eynden   +8 more
wiley   +1 more source

CD5 levels define functionally heterogeneous populations of naïve human CD4+ T cells

European Journal of Immunology, Volume 51, Issue 6, Page 1365-1376, June 2021., 2021
CD5lo and CD5hi naïve human CD4+ T cells differ in their gene expression profiles, affinity for foreign antigen, cytokine production after activation, and accumulation in the memory compartment. These findings have important implications in the identification of functionally biased T‐cell populations that can be exploited to improve cell therapies ...
Aditi Sood, Marie‐Ève Lebel, Mengqi Dong, Marilaine Fournier, Suzanne J. Vobecky, Élie Haddad, Jean‐Sébastien Delisle, Judith N. Mandl, Nienke Vrisekoop, Heather J. Melichar   +9 more
wiley   +1 more source