Obinutuzumab in Combination with Alternative Chlorambucil Schedules in Front-Line Treatment of Chronic Lymphocytic Leukemia: A Study by KroHem, the Croatian Cooperative Group for Hematologic Diseases [PDF]
BiomedicinesBackground/Objectives: Obinutuzumab was approved for front-line treatment of chronic lymphocytic leukemia in combination with chlorambucil pulses administered every 2 wks.
Igor Aurer +12 more
doaj +2 more sources
Chlorambucil and fludarabine as a new pre-transplant conditioning for patients with chronic lymphocytic leukemia: results of in vivo experiments [PDF]
Veterinární Medicína, 2008 Chronic lymphatic leukemia (CLL), incurable by standard treatments, may be potentially cured by allogeneic hematopoietic stem cell transplantation. Since CLL affects predominantly older people, there is a need for some low-toxicity conditioning with, on ...
J. Tomenendalova +5 more
doaj +2 more sources
Rituximab plus bendamustine or chlorambucil for chronic lymphocytic leukemia: primary analysis of the randomized, open-label MABLE study [PDF]
Haematologica, 2018 MABLE investigated the efficacy and safety of rituximab plus bendamustine or rituximab plus chlorambucil in fludarabine-ineligible patients with chronic lymphocytic leukemia.
Anne-Sophie Michallet +16 more
doaj +2 more sources
Pulmonary disease with chlorambucil therapy [PDF]
Cancer, 1978 A 73-year-old female developed pulmonary disease during treatment with chlorambucil for polycythemia vera. Cough and dyspnea were prominent symptoms. A chest roentgenogram revealed interstitial fibrosis. The diffusing capacity was markedly reduced. Pathologic findings included alveolar lining cell dysplasia, interstitial round cell infiltrates and ...
Alan U. Klatsky +2 more
openaire +4 more sources
Chlorambucil-Bearing Hybrid Molecules in the Development of Potential Anticancer Agents [PDF]
Molecules, 2023 Increasing cases of cancer have been a primary concern in recent decades. Developing new chemotherapeutics is challenging and has been faced with limitations, such as multidrug resistance, poor specificity, selectivity, and toxicity.
Sijongesonke Peter +1 more
doaj +2 more sources
Synthesis, Characterization, and Cytotoxicity Evaluation of Chlorambucil-Functionalized Mesoporous Silica Nanoparticles [PDF]
PharmaceuticsThis study describes the synthesis and characterization of chlorambucil (CLB)-functionalized mesoporous silica nanoparticles (MSNs) for potential application in cancer therapy.
Juliana Camila Fischer Karnopp +10 more
doaj +2 more sources
Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance
EMBO Molecular Medicine, 2019 Due to compromised homologous recombination (HR) repair, BRCA1‐ and BRCA2‐mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression.
Eliana MC Tacconi +23 more
doaj +2 more sources
Retrospective Safety Evaluation of Combined Chlorambucil and Toceranib for the Treatment of Different Solid Tumours in Dogs [PDF]
AnimalsChlorambucil is used in veterinary medicine for various cancers, while Toceranib, which was licenced for treating canine mast cell tumours, is now used against other solid tumours.
Yuk-Yin Lai +3 more
doaj +2 more sources
ClinicoEconomics and Outcomes Research, 2014 Thitima Kongnakorn,1 James A Sterchele,2 Christopher G Salvador,3 Denis Getsios,4 Mkaya Mwamburi51Evidera, Bangkok, Thailand; 2formerly of Teva Branded Pharmaceutical Products R&D, Inc, Frazer, PA, 3Oncology Market Research, Teva Branded ...
Kongnakorn T +4 more
doaj +3 more sources
Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells [PDF]
Beilstein Journal of NanotechnologyTheragnostic platforms, which integrate therapeutic and diagnostic capabilities, have gained significant interest in drug research because of to their potential advantages.
Thi Ngoc Han Pham +7 more
doaj +2 more sources