Results 91 to 100 of about 24,793 (292)

Effect of Thermal Treatment on the Antiproliferative and Antioxidant Activities of Garlic

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Heating garlic homogenate and baking or steaming garlic cloves caused no or moderate decrease in the total antioxidant capacity but decreased the alliinase activity, thiosulfinate content, and the antiproliferative activity (TAC) of garlic for ovarian cancer cells and fibroblasts.
Paulina Furdak, Grzegorz Bartosz, Izabela Sadowska‐Bartosz   +2 more
wiley   +1 more source

Rational Design of an Amphiphilic Chlorambucil Prodrug Realizing Self-Assembled Micelles for Efficient Anticancer Therapy.

ACS Biomaterials Science & Engineering, 2018
The application of anticancer drug chlorambucil (CLB) in chemotherapy is severely restricted by its insolubility, lability, and toxic side effects; therefore, it is challenging to realize a highly efficient anticancer therapy of chlorambucil.
Xu Hu, Ruiling Liu, Di Zhang, Jing Zhang, Zhonghao Li, Y. Luan   +5 more
semanticscholar   +1 more source

Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice. [PDF]

PLoS ONE, 2016
Previous NMR studies demonstrated that lonidamine (LND) selectively diminishes the intracellular pH (pHi) of DB-1 melanoma and mouse xenografts of a variety of other prevalent human cancers while decreasing their bioenergetic status (tumor βNTP/Pi ratio)
Kavindra Nath, David S Nelson, Mary E Putt, Dennis B Leeper, Bradley Garman, Katherine L Nathanson, Jerry D Glickson   +6 more
doaj   +1 more source

A Pt(IV) Prodrug Combining Chlorambucil and Cisplatin: A Dual-Acting Weapon for Targeting DNA in Cancer Cells

International Journal of Molecular Sciences, 2018
In this study, two DNA-targeting agents, cisplatin and chlorambucil, were combined in a Pt(IV) prodrug, 1, which was thoroughly characterized by means of spectroscopic and spectrometric techniques. Tested towards a panel of various human tumor cell lines,
Diego Montagner, D. Tolan, Emma Andriollo, V. Gandin, C. Marzano   +4 more
semanticscholar   +1 more source

Obinutuzumab treatment in the elderly patient with chronic lymphocytic leukemia

Clinical Interventions in Aging, 2015
Karen Seiter, Aleksandra Mamorska-DygaDepartment of Medicine, Division of Hematology/Oncology, New York Medical College, Valhalla, NY, USA Abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries ...
Seiter K, Mamorska-Dyga A
doaj  

In vitro activity of resorcinarene–chlorambucil conjugates for therapy in human chronic myelogenous leukemia cells

Drug Development and Industrial Pharmacy, 2019
A possible way of improving the activity and selectivity profile of antitumor agents is to design drug carrier systems employing soluble macromolecules.
Sonia Mendoza-Cardozo, L. D. Pedro-Hernández, Ulises Organista-Mateos, Luis Isaac Allende-Alarcón, E. Martínez-Klimova, T. Ramírez‐Ápan, M. Martínez-García   +6 more
semanticscholar   +1 more source

Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to the brain [PDF]

, 2004
The aim of this study was to evaluate glucose-bearing niosomes as a brain targeted delivery system for the vasoactive intestinal peptide (VIP). To this end, VIP/125I-VIP-loaded glucose-bearing niosomes were intravenously injected to mice.
Begley, Bickel, Bodanszky, Brant, Choeiri, Dick, Dobrogowska, Dogrukol-Ak, Domschke, Dufes, Dufes, Fahrenkrug, Gao, Gololobov, Gozes, Halmos, Hassan, La Manna, Lelièvre, Magistretti, Martin, Muller, Mutt, Pineau, Polt, Rayner, Robinson, Suzuki, Séjourné, Umezawa, Zilles, Önyüksel   +31 more
core   +2 more sources

Cancer therapy and reproductive impact

International Journal of Gynecology &Obstetrics, Volume 169, Issue 3, Page 891-894, June 2025.
Abstract All patients where the cancer treatment has gonadotoxic potential should be referred for oncofertility advice. The effect of chemotherapy and radiotherapy on the human ovary can vary from no impact to full‐blown premature ovarian failure due to hormonal and follicular depletion.
Dov Feldberg, Nikhil Purandare
wiley   +1 more source

ChlVPP combination chemotherapy for Hodgkin's disease: long-term results. [PDF]

, 1990
Two hundred and eighty-four patients with advanced Hodgkin's disease (HD) (stage II with poor prognostic features and stage III/IV) have been treated with the ChlVPP combination chemotherapy regimen (chlorambucil, vinblastine, procarbazine and ...
Brada, M, Forgeson, G, Gore, M, Mansi, J, Mbidde, E, Meldrum, M, Milan, S, Patel, P, Perren, T, Selby, P   +9 more
core   +2 more sources

Pregnancy after cancer: FIGO Best practice advice

International Journal of Gynecology &Obstetrics, Volume 169, Issue 3, Page 1119-1126, June 2025.
Abstract Advances in cancer care have led to a growing number of cancer survivors globally. As cancer increasingly affects women and people of reproductive age, more individuals will be experiencing pregnancy after completing cancer treatment. This Best Practice Advice manuscript describes the epidemiology of pregnancy after cancer, recommended ...
Cynthia Maxwell, Sumaiya Adam, Lina Bergman, Surabhi Nanda, Valerie Tiempo Guinto, Noa Popovits‐Hadari, Maisah Al‐Bakri, Ifeyinwa Nwokoro, Fionnuala McAuliffe, Inge Peters, Catherine Nelson‐Piercy, Frederic Amant, Melanie Nana, Graeme Smith, Jonathan Berek, Orla McNally, Long Nguyen‐Hoang, Virna P. Medina‐Palmezano, Sharleen O'Reilly, Francisco Ruiloba, Pat O'Brien, Bo Jacobsson, Sarikapan Wilailak, Liona C. Poon   +23 more
wiley   +1 more source