Results 181 to 190 of about 10,072 (202)
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Medical Hypotheses, 1980
Chlorambucil alkylation of pyridine, a model for nucleotides, appears to be first order in chlorambucil, but zero order in pyridine, and is strongly inhibited by dimethylsulfoxide. The same results are seen with chlorambucilyl [3H]prolyl proline; full alkylation activity was regained upon removal of dimethylsulfoxide.
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Chlorambucil alkylation of pyridine, a model for nucleotides, appears to be first order in chlorambucil, but zero order in pyridine, and is strongly inhibited by dimethylsulfoxide. The same results are seen with chlorambucilyl [3H]prolyl proline; full alkylation activity was regained upon removal of dimethylsulfoxide.
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Treatment of Behcet's Disease With Chlorambucil
Archives of Ophthalmology, 1970Eleven patients with Behcet's (and neuro-Behcet's) disease in the active and progressive stages were treated with chlorambucil (Leukeran). Follow-up varied between three weeks and 17 months. Results were favorable in all, and the drug was superior to other forms of treatment in that there was arrest and some amelioration of the disease.
Jubran G. Mamo, Samir A. Azzam
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Kinetics and Mechanism of Chlorambucil Hydrolysis
Journal of Pharmaceutical Sciences, 1979The kinetics and mechanism of hydrolysis of the cytotoxic drug chlorambucil were investigated. A study of the reaction order and of the pH, dielectric constant, and ionic strength effects on the reaction rate revealed that the hydrolysis was a limiting unimolecular nucleophilic substitution, the rate-determining step being the ionization of the first 2-
Owen W.R., Stewart P.J.
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THE ONCOGENICITY OF CHLORAMBUCIL IN RHEUMATOID ARTHRITIS
Rheumatology, 1988Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent. A retrospective survey was performed to assess the incidence of all types of malignancy in 39 patients treated with chlorambucil (mean daily dose 4.25 mg, mean duration of ...
Milton Cohen +6 more
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Potentiation of chlorambucil activity by phenylbutazone
Cancer Letters, 1978Phenylbutazone increased the cytotoxicity of chlorambucil to L1210 and P388 leukemia cells in vitro by displacing alkylating agent bound to serum of the tissue culture medium. Administration of phenylbutazone with chlorambucil to mice bearing the P388 tumor lowers the dose of chlorambucil required to achieve maximum increase in life span, but also ...
Yoshimasa Uehara +3 more
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Chlorambucil in Behçet's Disease
Ophthalmology, 1983Ten patients with Behçet's disease were treated with chlorambucil alone. At the therapeutic drug level of 0.2 mg/kg, seven patients developed oligospermia and three patients developed azoospermia. A 30-year-old patient underwent a testicular biopsy two years after the cessation of therapy. Histopathology revealed evidence of testicular atrophy. Fifteen
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Chlorambucil carcinogenesis in BALBc mice
Cancer Letters, 1990Chlorambucil, a drug used in the treatment of neoplastic and non-neoplastic disease, was administered by gavage to BALB/c mice at a dose of 1.0 mg/kg body wt. 5 times per week for 12 weeks to test its carcinogenicity. The survival was statistically reduced in treated animals of both sexes (P less than 0.001).
Antonio Cavaliere +3 more
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Chlorambucil Therapy in Sympathetic Ophthalmia
American Journal of Ophthalmology, 1995We used chlorambucil therapy in a 28-year-old man with sympathetic ophthalmia, which was incompletely controlled with systemic corticosteroids, and the patient developed serious side effects.The patient sustained a penetrating injury with an intraocular metal foreign body. Attempts to remove it with a magnet failed.
Jorn Hon Liu, Chang-Sue Yang
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Lichen Myxedematosus Treated with Chlorambucil
The Journal of Dermatologic Surgery and Oncology, 1993BACKGROUND. Chemotherapy with various alkylating agents has been reported to be successful in the treatment of lichen myxedematosus. However, serious toxicities have accompanied such use.OBJECTIVE. To report a case of treatment of lichen myxedematosus with chlorambucil.RESULT.
Keyoumars Soltani +3 more
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Necrobiotic xanthogranuloma: Response to chlorambucil
Australasian Journal of Dermatology, 2010ABSTRACTThis report of necrobiotic xanthogranuloma associated with chronic lymphocytic leukaemia describes the response of skin lesions to chlorambucil. Characteristic clinical and histological features of necrobiotic xanthogranuloma are presented, as well as a discussion regarding management and the use of chlorambucil.
Lachlan Warren, Ferenc Szabo, Emma Ryan
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