Results 181 to 190 of about 23,600 (247)

Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial

Lancet Oncology, The, 2019
BACKGROUND Both single-agent ibrutinib and chlorambucil plus obinutuzumab have shown superior efficacy to chlorambucil monotherapy and are standard first-line treatments in chronic lymphocytic leukaemia.
Carol Moreno, Richard F Greil, Fatih Demirkan   +2 more
exaly   +2 more sources

Venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab for previously untreated chronic lymphocytic leukaemia (CLL14): follow-up results from a multicentre, open-label, randomised, phase 3 trial.

The Lancet Oncology, 2020
BACKGROUND Venetoclax plus obinutuzumab has been established as a fixed-duration treatment regimen for patients with chronic lymphocytic leukaemia.
O. Al-Sawaf, Can Zhang, M. Tandon, Arijit Sinha, A. Fink, S. Robrecht, O. Samoylova, A. Liberati, J. Pinilla-Ibarz, Stephen Samuel Opat, L. Sivcheva, K. Le Dû, L. Fogliatto, C. Niemann, R. Weinkove, S. Robinson, T. Kipps, E. Tausch, W. Schary, M. Ritgen, C. Wendtner, K. Kreuzer, B. Eichhorst, S. Stilgenbauer, M. Hallek, K. Fischer   +25 more
semanticscholar   +1 more source

Temperature‐responsive voltammetric sensor based on stimuli-sensitive semi-interpenetrating polymer network conductive microgels for reversible switch detection of nitrogen mustard analog chlorambucil (Leukeran™)

, 2021
In this study, we report the synthesis of thermosensitive poly(N-vinylcaprolactam) semi-interpenetrated conductive polypyrrole microgels (PVCL/PPY semi-IPN MGs) for “on-off” switchable electrochemical sensing of carcinogenic nitrogen mustard drug ...
B. Mutharani, P. Ranganathan, Shen-ming Chen, Hsieh‐Chih Tsai   +3 more
semanticscholar   +1 more source

Acalabrutinib ± obinutuzumab versus obinutuzumab + chlorambucil in treatment-naïve chronic lymphocytic leukemia: Elevate-TN four-year follow up.

, 2021
7509Background: Early results from ELEVATE-TN (NCT02475681) at a median follow-up of 28.3 mo demonstrated superior efficacy of acalabrutinib (A) ± obinutuzumab (O) compared with O + chlorambucil (C...
J. Sharman, M. Egyed, W. Jurczak, A. Skarbnik, J. Pagel, M. Kamdar, T. Munir, G. Corbett, L. Fogliatto, Y. Herishanu, V. Banerji, S. Coutre, P. Walker, K. Karlsson, P. Ghia, A. Janssens, W. Wierda, P. Patel, M. Wang, J. Byrd   +19 more
semanticscholar   +1 more source

A peptide-drug hydrogel to enhance the anti-cancer activity of chlorambucil.

Biomaterials Science, 2020
The clinical applications of nitrogen mustard antitumor drugs are limited by their poor aqueous solubility, poor cellular uptake, lack of targeting, and severe side effects.
Qingxiang Guo, Yifan Liu, Ganen Mu, Lijun Yang, Wei Wang, Jinjian Liu, Jianfeng Liu   +6 more
semanticscholar   +1 more source

Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): a randomised, multicentre, open-label phase 3 trial

Lancet, The, 2015
Peter Hillmen, Tadeusz Robak, Sebastian Grosicki   +2 more
exaly   +2 more sources

Enzyme-responsive sulfatocyclodextrin/prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil.

Chemical Communications, 2019
Supramolecular drug delivery systems are becoming an increasingly important part in controlled drug release. In this work, we report a novel enzyme-responsive supramolecular assembly directly constructed using biocompatible sulfato-β-cyclodextrin (SCD ...
X. Guan, Yong Chen, Xuan Wu, Peiyu Li, Yu Liu   +4 more
semanticscholar   +1 more source

Redox-Driven Disassembly of Polymer–Chlorambucil Polyprodrug: Delivery of Anticancer Nitrogen Mustard and DNA Alkylation

ACS Applied Polymer Materials, 2019
Utilization of nitrogen mustards as anticancer drugs opened the way for precise cancer chemotherapy owing to their ability to cross-link deoxyribonucleic acid (DNA).
B. Saha, S. Bhattacharyya, Sourav Mete, Arindam Mukherjee, P. De   +4 more
semanticscholar   +1 more source

Evaluating Ternary Metal Oxide (TMO) core-shell nanocomposites for the rapid determination of the anti-neoplastic drug Chlorambucil (Leukeran™) by electrochemical approaches.

Materials Science and Engineering C: Materials for Biological Applications, 2019
A functional ternary nanocomposite (MnO2@NiFe2O4) with hierarchically grown flower-like core-shell assembly has been prepared through a simple two-step hydrothermal methodology.
Kogularasu Sakthivel, Akilarasan Muthumariappan, Shen-ming Chen, Yi-Ling Li, Tse-Wei Chen, M. A. Ali   +5 more
semanticscholar   +1 more source

Supramolecular Hydrogel Based on Chlorambucil and Peptide Drug for Cancer Combination Therapy.

ACS Applied Materials and Interfaces, 2018
Supramolecular hydrogels of self-assembling peptide-drug conjugates have been considered as effective self-delivery drug systems for cancer therapy in recent years.
Lijun Yang, Congrou Zhang, Chunhua Ren, Jinjian Liu, Yumin Zhang, Jing Wang, Fan Huang, Lei Zhang, Jianfeng Liu   +8 more
semanticscholar   +1 more source