Real world risk of infusion reactions and effectiveness of front-line obinutuzumab plus chlorambucil compared with other frontline treatments for chronic lymphocytic leukemia [PDF]
BMC Cancer, 2022 Background Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in North America. Previous studies have shown improved progression free survival (PFS) and response rates in unfit patients treated with obinutuzumab compared to other ...
Nicole Bourrier +11 more
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Cytotoxicity of chlorambucil immobilized on magnetic iron oxide nanoparticles Fe3O4 [PDF]
Micro & Nano Letters, 2021 Chlorambucil is a nitrogen mustard alkylating agent used for the treatment of various malignant and non‐malignant cancers. The use of the chemotherapeutic is limited by its toxic side effects which precludes the use of optimal doses.
Julia Nowak‐Jary +2 more
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Chlorambucil-Induced Acute Interstitial Pneumonitis [PDF]
Case Reports in Hematology, 2014 Chlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL ...
Hammad Shafqat, Adam J. Olszewski
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Obinutuzumab in Combination with Alternative Chlorambucil Schedules in Front-Line Treatment of Chronic Lymphocytic Leukemia: A Study by KroHem, the Croatian Cooperative Group for Hematologic Diseases [PDF]
BiomedicinesBackground/Objectives: Obinutuzumab was approved for front-line treatment of chronic lymphocytic leukemia in combination with chlorambucil pulses administered every 2 wks.
Igor Aurer +12 more
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Combined Application of CAR-T Cells and Chlorambucil for CLL Treatment: Insights from Nonlinear Dynamical Systems and Model-Based Design for Dose Finding [PDF]
HematoBackground: This work presents a mechanistic nonlinear model, formulated as a system of first-order Ordinary Differential Equations, to investigate the dynamics of Chronic Lymphocytic Leukemia (CLL) under combined chemoimmunotherapy using CAR-T cells and
Paul A. Valle +4 more
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Chlorambucil Monotherapy in Dogs with Protein-Losing Nephropathy of Probable Immune Origin: A Preliminary Study [PDF]
Veterinary SciencesProtein-losing nephropathy (PLN) involves a heterogeneous group of pathologies leading to selective glomerular damage and development of renal disease. ICGN, the main cause of PLN, requires immunosuppressive treatment. However, the scientific evidence in
Felipe Díaz-Soler +5 more
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Sustained efficacy and detailed clinical follow-up of first-line ibrutinib treatment in older patients with chronic lymphocytic leukemia: extended phase 3 results from RESONATE-2 [PDF]
Haematologica, 2018 Results of RESONATE-2 (PCYC-1115/1116) supported approval of ibrutinib for first-line treatment of chronic lymphocytic leukemia. Extended analysis of RESONATE-2 was conducted to determine long-term efficacy and safety of ibrutinib in older patients with ...
Paul M. Barr +20 more
doaj +10 more sources
Treatment outcomes of dogs with transitional cell carcinoma [PDF]
Frontiers in Veterinary ScienceTransitional cell carcinoma (TCC) is the most prevalent cancer of the urinary tract in dogs. The prognosis is often poor, and the optimal standard treatment has not been established. The objectives of this study were to (1) describe the clinical outcomes
Ka To Chu +3 more
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Partial Remission Without Recurrence in a 9-Year-Old Golden Retriever with Nasal Carcinoma Treated with Prednisolone/Chlorambucil Metronomic Combination Therapy: A Case Report and Literature Review of Molecular Mechanisms [PDF]
Current Issues in Molecular BiologyThis paper reports the first case in which a hyperlipidemic retriever (due to hypothyroidism) with a nasal tumor was successfully treated—achieving partial remission—and managed using a metronomic combination of chlorambucil (3.74 mg/m2, SID) and ...
Kyuhyung Choi
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Synthesis, Characterization, and Cytotoxicity Evaluation of Chlorambucil-Functionalized Mesoporous Silica Nanoparticles [PDF]
PharmaceuticsThis study describes the synthesis and characterization of chlorambucil (CLB)-functionalized mesoporous silica nanoparticles (MSNs) for potential application in cancer therapy.
Juliana Camila Fischer Karnopp +10 more
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