Results 11 to 20 of about 10,072 (202)

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics [PDF]

Beilstein Journal of Nanotechnology
Theragnostics has become a popular term nowadays, since it enables both diagnosis and therapy at the same time while only using one carrier platform.
Phuong-Thao Dang-Luong, Hong-Phuc Nguyen, Loc Le-Tuan, Xuan-Thang Cao, Vy Tran-Anh, Hieu Vu Quang   +5 more
doaj   +2 more sources

Economic evaluation of obinutuzumab in combination with chlorambucil in first-line treatment of patients with chronic lymphocytic leukemia in Spain [PDF]

ClinicoEconomics and Outcomes Research, 2016
Luis Felipe Casado,1 Amparo Burgos,2 Eva González-Haba,3 Javier Loscertales,4 Tania Krivasi,5 Javier Orofino,6 Carlos Rubio-Terres,7 Darío Rubio-Rodríguez7 1Hematology Department, Hospital Virgen de la Salud, Toledo, Spain; 2Pharmacy
Casado LF, Burgos A, González-Haba E, Loscertales J, Krivasi T, Orofino J, Rubio-Terres C, Rubio-Rodríguez D   +7 more
doaj   +1 more source

Cumulative review of cardiac failure with acalabrutinib in the treatment of chronic lymphocytic leukemia using data from clinical trials and postmarketing experience. [PDF]

Hemasphere
HemaSphere, Volume 9, Issue 4, April 2025.
Ghia P, Bajwa N, Corry AJ, Jannuru S, Kreuzbauer G, Pareek M.   +5 more
europepmc   +2 more sources

Prospective Estimation of the Prevalence of Thromboembolism in Dogs With Inflammatory Protein-Losing Enteropathy. [PDF]

J Vet Intern Med
ABSTRACT Background Inflammatory protein‐losing enteropathy (iPLE) is thought to be associated with a hypercoagulable state and may predispose dogs to thromboembolism (TE). However, little information is available regarding the prevalence of TE in dogs with iPLE.
Oishi N, Ohta H, Tamura M, Hanazono K, Miyoshi K, Yokoyama N, Shinbo G.   +6 more
europepmc   +2 more sources

In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs. [PDF]

PLoS ONE, 2018
The objective of this study was to investigate a possible mechanism of action of metronomic chlorambucil on glioma by studying the in vitro cytotoxicity and anti-angiogenic effects on glioma and endothelial cells, respectively. The in vitro LD50 and IC50
Michael J Reese, Deborah W Knapp, Kimberly M Anderson, Julie A Mund, Jamie Case, David R Jones, Rebecca A Packer   +6 more
doaj   +1 more source

Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects

Journal for ImmunoTherapy of Cancer, 2023
Background Tumor intracellular programmed cell death ligand-1 (PDL1) mediates pathologic signals that regulate clinical treatment responses distinctly from surface-expressed PDL1 targeted by αPDL1 immune checkpoint blockade antibodies.Methods We ...
Tyler Curiel, Yilun Deng, Aravind Kancharla, Myrna Garcia, Haiyan Bai, Ryan Michael Reyes, Harshita B Gupta, Alvaro S Padron, Anand V R Kornepati, Jose R Conejo-Garcia, Yiji J Liao, Clare J Murray, Carlos Ontiveros, Suresh J Kari   +13 more
doaj   +1 more source

Synthesis, Photophysical Properties and Biological Evaluation of New Conjugates BODIPY: Dinuclear Trithiolato‐Bridged Ruthenium(II)‐Arene Complexes

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Fifteen new dinuclear arene‐ruthenium (II)‐BODIPY conjugates were synthesized. Despite a fluorescence quenching effect, these conjugates can be used as fluorescent tracers. Their antiparasitic activity but also their toxicity against healthy human foreskin fibroblasts (HFFs) was reduced compared to the parent ruthenium compounds.
Oksana Desiatkina, Ghalia Boubaker, Nicoleta Anghel, Yosra Amdouni, Andrew Hemphill, Julien Furrer, Emilia Păunescu   +6 more
wiley   +1 more source

Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review

Environmental and Molecular Mutagenesis, Volume 63, Issue 8-9, Page 376-388, December 2022., 2022
Abstract The OECD Test Guideline 488 (TG 488) for the Transgenic Rodent Gene Mutation Assay has undergone several revisions to update the recommended design for studying mutations in somatic tissues and male germ cells. The recently revised TG recommends a single sampling time of 28 days following 28 days of exposure (i.e., 28 + 28 days) for all ...
George R. Douglas, Carol Beevers, Bhaskar Gollapudi, Zena Keig‐Shevlin, David Kirkland, Jason M. O'Brien, Jan van Benthem, Carole L. Yauk, Robert R. Young, Francesco Marchetti   +9 more
wiley   +1 more source

The spectrum of subclonal TP53 mutations in chronic lymphocytic leukemia: A next generation sequencing retrospective study

Hematological Oncology, Volume 40, Issue 5, Page 962-975, December 2022., 2022
Abstract Chronic lymphocytic leukemia (CLL) is a hematological disorder with complex clinical and biological behavior. TP53 mutational status and cytogenetic assessment of the deletion of the corresponding locus (17p13.1) are considered the most relevant biomarkers associated with pharmaco‐predictive response, chemo‐refractoriness, and worse prognosis ...
Giuseppa De Luca, Giannamaria Cerruti, Sonia Lastraioli, Romana Conte, Adalberto Ibatici, Nikki Di Felice, Fortunato Morabito, Paola Monti, Gilberto Fronza, Serena Matis, Monica Colombo, Sonia Fabris, Alessia Ciarrocchi, Antonino Neri, Paola Menichini, Manlio Ferrarini, Paolo Nozza, Franco Fais, Giovanna Cutrona, Mariella Dono   +19 more
wiley   +1 more source

Chronic Lymphocytic Leukemia: 2025 Update on the Epidemiology, Pathogenesis, Diagnosis, and Therapy. [PDF]

Am J Hematol
ABSTRACT Disease Overview Chronic lymphocytic leukemia (CLL) is the most frequent type of leukemia. It typically occurs in older patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that interfere with the regulation of proliferation and apoptosis in clonal B‐cells.
Hallek M.
europepmc   +2 more sources