Results 11 to 20 of about 10,587 (186)

2D and 3D anticancer activity of diiron bis-cyclopentadienyl complexes incorporating flurbiprofen and chlorambucil. [PDF]

RSC Med Chem
Biancalana L, De Franco M, Gandin V, Marchetti F.   +3 more
europepmc   +3 more sources

Retrospective Safety Evaluation of Combined Chlorambucil and Toceranib for the Treatment of Different Solid Tumours in Dogs [PDF]

Animals
Chlorambucil is used in veterinary medicine for various cancers, while Toceranib, which was licenced for treating canine mast cell tumours, is now used against other solid tumours.
Yuk-Yin Lai, Rodrigo Dos Santos Horta, Paola Valenti, Antonio Giuliano   +3 more
doaj   +2 more sources

Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions [PDF]

New England Journal of Medicine, 2014
Clemens-Martin Wendtner, Javier De La Serna, Stephen Opat   +2 more
exaly   +2 more sources

Chlorambucil combination therapy in refractory serpiginous choroiditis: A cure?

American Journal of Ophthalmology Case Reports, 2021
Purpose: To find a remedy for serpiginous choroiditis refractory to oral prednisone and chlorambucil treatment. Observations: Eight eyes of four patients (all female) with advanced macular involvement secondary to serpiginous choroiditis were included in
Arash Maleki, Anapatricia Maldonado Cerda, Cristina M. Garcia, Mike Zein, Ambika Manhapra, C. Stephen Foster   +5 more
doaj   +1 more source

In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs. [PDF]

PLoS ONE, 2018
The objective of this study was to investigate a possible mechanism of action of metronomic chlorambucil on glioma by studying the in vitro cytotoxicity and anti-angiogenic effects on glioma and endothelial cells, respectively. The in vitro LD50 and IC50
Michael J Reese, Deborah W Knapp, Kimberly M Anderson, Julie A Mund, Jamie Case, David R Jones, Rebecca A Packer   +6 more
doaj   +1 more source

Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects

Journal for ImmunoTherapy of Cancer, 2023
Background Tumor intracellular programmed cell death ligand-1 (PDL1) mediates pathologic signals that regulate clinical treatment responses distinctly from surface-expressed PDL1 targeted by αPDL1 immune checkpoint blockade antibodies.Methods We ...
Tyler Curiel, Yilun Deng, Aravind Kancharla, Myrna Garcia, Haiyan Bai, Ryan Michael Reyes, Harshita B Gupta, Alvaro S Padron, Anand V R Kornepati, Jose R Conejo-Garcia, Yiji J Liao, Clare J Murray, Carlos Ontiveros, Suresh J Kari   +13 more
doaj   +1 more source

Chlorambucil-Loaded Graphene-Oxide-Based Nano-Vesicles for Cancer Therapy

Pharmaceutics, 2023
In this study, the authors have designed biocompatible nano-vesicles using graphene oxide (GO) for the release of chlorambucil (CHL) drugs targeting cancerous cells.
Surabhi Kumari, Anuj Nehra, Kshitij Gupta, Anu Puri, Vinay Kumar, Krishna Pal Singh, Mukesh Kumar, Ashutosh Sharma   +7 more
doaj   +1 more source

Nasal Lymphoma with Low Mitotic Index in Three Cats Treated with Chlorambucil and Prednisolone

Veterinary Sciences, 2022
Lymphoma is the most common tumor of the nasal cavity in cats. Commonly used treatment modalities are radiotherapy and chemotherapy, or both. Typical chemotherapy protocols used in cats with nasal lymphoma are COP (cyclophosphamide, vincristine ...
Karen W. L. Ng, Julia A. Beatty, May P. Y. Tse, Antonio Giuliano   +3 more
doaj   +1 more source

Long-term management of a cat with nasopharyngeal lymphoma by chlorambucil [PDF]

Open Veterinary Journal, 2021
Background: Lymphoma in the nasal cavity is the most common tumor of cats' upper respiratory tract. However, the effect of single-agent chlorambucil on nasal or nasopharyngeal lymphoma has not been evaluated in cats.
Kaho Takahashi, Takashi Baba, Marin Hirokawa, Masaki Miyajima, Miori Kishimoto, Junpei Kimura, Hirotaka Kondo, Keitaro Ohmori   +7 more
doaj   +1 more source

Case Report: Long-Term Survival of a Dog With Chronic Lymphocytic Leukemia Treated With Chlorambucil, Prednisolone, and Imatinib

Frontiers in Veterinary Science, 2022
A 7-year-old castrated male Poodle dog presented with chronic progressive lymphocytosis. Hematologic and peripheral blood smear findings included remarkable lymphocytosis with well-differentiated small lymphocytes. Cytology of bone marrow aspirate showed
Ga-Won Lee, Min-Hee Kang, Jin-Ha Jeon, Doo-Won Song, Woong-Bin Ro, Heyong-Seok Kim, Hee-Myung Park   +6 more
doaj   +1 more source