Results 41 to 50 of about 23,600 (247)

Chemical Reactivity of Chlorambucil in Organic Solvents: Influence of 4-Chloro Butyronitrile Nucleophile to Voltammogram Profiles

International Journal of Electrochemical Science, 2011
Chlorambucil is one of anticancer drug that has been mainly used in the treatment of cancer disease. It is an alkylating agent and can be given orally.
Henry Setiyanto, Vienna Saraswaty, Rukman Hertadi, Indra Noviandri, Buchari Buchari   +4 more
doaj   +1 more source

Real-world clinical experience in the Connect® chronic lymphocytic leukaemia registry: a prospective cohort study of 1494 patients across 199 US centres. [PDF]

, 2016
The clinical course of chronic lymphocytic leukaemia (CLL) is heterogeneous, and treatment options vary considerably. The Connect® CLL registry is a multicentre, prospective observational cohort study that provides a real-world perspective on the ...
Farber, Charles M, Flick, E Dawn, Flinn, Ian W, Flowers, Christopher R, Grinblatt, David L, Kay, Neil E, Kipps, Thomas J, Kiselev, Pavel, Kozloff, Mark F, Lamanna, Nicole, Mato, Anthony, Nabhan, Chadi, Sharman, Jeff P, Sullivan, Kristen, Swern, Arlene S, Weiss, Mark A   +15 more
core   +1 more source

Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7

International Journal of Molecular Sciences, 2020
l-type amino acid transporter 1 (LAT1) is an amino acid transporter that is overexpressed in several types of cancer and, thus, it can be a potential target for chemotherapy.
Piman Pocasap, N. Weerapreeyakul, Juri M. Timonen, Juulia Järvinen, J. Leppänen, Jussi Kärkkäinen, J. Rautio   +6 more
semanticscholar   +1 more source

Chronic lymphocytic leukaemia: Up-dated recommendations on diagnosis and treatment [PDF]

, 2004
Diagnosis and treatment of chronic lymphatic leukaemia (CLL) are currently undergoing great change. New knowledge of prognosis factors and the numerous new therapeutic procedures now available, such as purine analogues, high-dose treatment and monoclonal
Bergmann, M., Emmerich, B., Hallek, M.
core   +1 more source

Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves [PDF]

, 2016
To the Editor: Makkar et al. (Nov. 19 issue)(1) report possible subclinical leaflet thrombosis in up to 40% of patients involved in a clinical trial of transcatheter aortic-valve replacement (TAVR).
Burriesci, Gaetano, Colli, Andrea, Ducci, Andrea   +2 more
core   +2 more sources

Chlorambucil-Induced Acute Interstitial Pneumonitis

Case Reports in Hematology, 2014
Chlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL ...
Hammad Shafqat, Adam J. Olszewski
doaj   +1 more source

The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia [PDF]

, 1988
We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL).
Aabo, Anderson, Boumsell, Byhardt, Catovsky, Durum, Enno, Foa, Foa, Herrman, Horning, Johnson, Markey, Martin, McCann, Mills, Mittelman, Paule, Platsoucas, Roncadin, Rovston, Spivak, Terstappen, Terstappen, Vann   +24 more
core   +3 more sources

Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors

Molecules, 2019
Extracellular acidification is an important feature of tumor microenvironments but has yet to be successfully exploited in cancer therapy. The reversal of the pH gradient across the plasma membrane in cells that regulate intracellular pH (pHi) has ...
Michael P. Hay, Hong Nam Shin, Way Wua Wong, Wan Wan Sahimi, Aaron T.D. Vaz, Pooja Yadav, Robert F. Anderson, Kevin O. Hicks, William R. Wilson   +8 more
doaj   +1 more source

DNA crosslinking and biological activity of a hairpin polyamide–chlorambucil conjugate [PDF]

, 2003
A prototype of a novel class of DNA alkylating agents, which combines the DNA crosslinking moiety chlorambucil (Chl) with a sequence-selective hairpin pyrrole-imidazole polyamide ImPy-beta-ImPy-gamma-ImPy-beta-Dp (polyamide 1), was evaluated for its ...
Beerman, Terry A., Dervan, Peter B., Dziegielewska, Barbara, Dziegielewski, Jaroslaw, Wang, Yong-Dong, Wurtz, Nicholas R.   +5 more
core   +2 more sources

A five‐year follow‐up of untreated patients with chronic lymphocytic leukaemia treated with ofatumumab and chlorambucil: final analysis of the Complement 1 phase 3 trial

British Journal of Haematology, 2020
The Complement 1 trial investigated the efficacy and safety of ofatumumab + chlorambucil with chlorambucil monotherapy in patients with previously untreated chronic lymphocytic leukaemia (CLL). On long‐term follow‐up in the chemoimmunotherapy arm vs. the
F. Offner, T. Robak, A. Janssens, K. Govind Babu, J. Kłoczko, S. Grosicki, J. Mayer, P. Panagiotidis, A. Schuh, A. Pettitt, M. Montillo, Olena Werner, Ghislaine Vincent, Sadhvi Khanna, P. Hillmen   +14 more
semanticscholar   +1 more source