Results 41 to 50 of about 10,072 (202)
Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors
Molecules, 2019 Extracellular acidification is an important feature of tumor microenvironments but has yet to be successfully exploited in cancer therapy. The reversal of the pH gradient across the plasma membrane in cells that regulate intracellular pH (pHi) has ...
Michael P. Hay +8 more
doaj +1 more source
Haematologica, 2019 The aim of this study was to investigate long-term outcome following first-line therapy in consecutive chronic lymphocytic leukemia (CLL) patients in a well-defined geographic area: Sweden.
Sandra Eketorp Sylvan +16 more
doaj +1 more source
Journal of Feline Medicine and Surgery Open Reports, 2023 Case summary A 12-year-old male neutered domestic shorthair cat presented with a 2-week history of serous unilateral nasal discharge, swelling of the nasal bridge and sneezing.
Sho Goto +3 more
doaj +1 more source
Pharmaceutics, 2022 Cancer with all its more than 200 variants continues to be a major health problem around the world with nearly 10 million deaths recorded in 2020, and leukemia accounted for more than 300,000 cases according to the Global Cancer Observatory. Although new
Paul A. Valle +4 more
doaj +1 more source
BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
Necrobiotic xanthogranuloma treated with chlorambucil
Dermatology Online Journal, 2006 We report a case of necrobiotic xanthogranuloma that responded to treatment with chlorambucil. A 56-year-old man presented with a 5-year history of multiple, mildly pruritic, brown-to-violaceous plaques with central ulceration and atrophy involving the periorbital area, extremities, and trunk.
Torabian, Sima Z +2 more
openaire +4 more sources
Hybrid inhibitors of DNA and HDACs remarkably enhance cytotoxicity in leukaemia cells
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Chlorambucil is a nitrogen mustard-based DNA alkylating drug, which is widely used as a front-line treatment of chronic lymphocytic leukaemia (CLL). Despite its widespread application and success for the initial treatment of leukaemia, a majority of ...
Yoojin Song +4 more
doaj +1 more source
Chronic Lymphocytic Leukemia in Elderly Patients: Own Experience
Львівський клінічний вісник, 2017 Introduction. The annual incidence rate of chronic lymphocytic leukemia (CLL) in Europe is 14 per 100 000 population. The disease is more common in older patients.
Vyhovska O. +7 more
doaj +1 more source
Cancer therapy and reproductive impact
International Journal of Gynecology &Obstetrics, EarlyView.Abstract All patients where the cancer treatment has gonadotoxic potential should be referred for oncofertility advice. The effect of chemotherapy and radiotherapy on the human ovary can vary from no impact to full‐blown premature ovarian failure due to hormonal and follicular depletion.
Dov Feldberg, Nikhil Purandare
wiley +1 more source
Frontiers in Oncology, 2020 Previous studies investigated the efficacy and the safety of bendamustine (B) vs. chlorambucil (Chl) associated with rituximab (R) in fludarabine-ineligible patients with treated and untreated chronic lymphocytic leukemia (CLL).
Francesco Autore +19 more
doaj +1 more source