Results 41 to 50 of about 19,748 (246)

The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia [PDF]

open access: yes, 1988
We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL).
Aabo   +24 more
core   +3 more sources

Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors

open access: yesMolecules, 2019
Extracellular acidification is an important feature of tumor microenvironments but has yet to be successfully exploited in cancer therapy. The reversal of the pH gradient across the plasma membrane in cells that regulate intracellular pH (pHi) has ...
Michael P. Hay   +8 more
doaj   +1 more source

First-line treatment of chronic lymphocytic leukemia with ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab: final analysis of the randomized, phase III iLLUMINATE trial

open access: yesHaematologica, 2022
iLLUMINATE is a randomized, open-label phase III study of ibrutinib plus obinutuzumab (n=113) versus chlorambucil plus obinutuzumab (n=116) as first-line therapy for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.
Carol Moreno   +15 more
doaj   +1 more source

Chronic lymphocytic leukaemia: Up-dated recommendations on diagnosis and treatment [PDF]

open access: yes, 2004
Diagnosis and treatment of chronic lymphatic leukaemia (CLL) are currently undergoing great change. New knowledge of prognosis factors and the numerous new therapeutic procedures now available, such as purine analogues, high-dose treatment and monoclonal
Bergmann, M., Emmerich, B., Hallek, M.
core   +1 more source

Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves [PDF]

open access: yes, 2016
To the Editor: Makkar et al. (Nov. 19 issue)(1) report possible subclinical leaflet thrombosis in up to 40% of patients involved in a clinical trial of transcatheter aortic-valve replacement (TAVR).
Burriesci, Gaetano   +2 more
core   +2 more sources

Direct C─H Lactonization of Carboxylic Acids Enabled by LMCT Photoactivation

open access: yesAngewandte Chemie, Volume 138, Issue 1, 2 January 2026.
We report a photochemical method for oxidative γ‐C─H lactonization of simple carboxylic acid substrates upon LMCT photoactivation. Intriguingly, these conditions suppress the rapid decarboxylation characteristic of oxidized carboxylates, suggesting the intermediacy of metal‐stabilized acyloxy radical instead of the dissociative process typically ...
Kathryn M. Weber   +6 more
wiley   +2 more sources

First-line therapy in chronic lymphocytic leukemia: a Swedish nation-wide real-world study on 1053 consecutive patients treated between 2007 and 2013

open access: yesHaematologica, 2019
The aim of this study was to investigate long-term outcome following first-line therapy in consecutive chronic lymphocytic leukemia (CLL) patients in a well-defined geographic area: Sweden.
Sandra Eketorp Sylvan   +16 more
doaj   +1 more source

Successful rescue treatment using chlorambucil for presumed recurrence of sinonasal lymphoma in a cat

open access: yesJournal of Feline Medicine and Surgery Open Reports, 2023
Case summary A 12-year-old male neutered domestic shorthair cat presented with a 2-week history of serous unilateral nasal discharge, swelling of the nasal bridge and sneezing.
Sho Goto   +3 more
doaj   +1 more source

Chemoimmunotherapy Administration Protocol Design for the Treatment of Leukemia through Mathematical Modeling and In Silico Experimentation

open access: yesPharmaceutics, 2022
Cancer with all its more than 200 variants continues to be a major health problem around the world with nearly 10 million deaths recorded in 2020, and leukemia accounted for more than 300,000 cases according to the Global Cancer Observatory. Although new
Paul A. Valle   +4 more
doaj   +1 more source

Low Dose Pegylated Interferon Alpha as a First‐Line Treatment for Necrobiotic Xanthogranuloma

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Necrobiotic xanthogranuloma (NXG) is a rare, progressive granulomatous disorder frequently associated with monoclonal gammopathy, particularly monoclonal gammopathy of undetermined significance (MGUS). It typically presents with indurated to ulcerative yellowish plaques or nodules, often with ocular involvement.
Ishana Dixit   +2 more
wiley   +1 more source

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