Results 251 to 260 of about 242,404 (349)

Antimicrobial Photodynamic Therapy in the Treatment of Diabetic Foot Ulcers: A Pilot Randomized Clinical Trial

open access: yesJournal of Biophotonics, Volume 19, Issue 5, May 2026.
This randomized pilot study evaluated photodynamic therapy as an adjunctive treatment for diabetic foot ulcers compared with conventional care. The findings demonstrated a greater reduction in lesion area in the intervention group and potential benefits in the microbiological profile of the wounds, suggesting the clinical relevance and therapeutic ...
Maria Girlane Sousa Albuquerque Brandão   +6 more
wiley   +1 more source

Population Pharmacokinetics and Dosing Simulations of Pentobarbital in the Pediatric Population

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Pentobarbital is a barbiturate with sedative and anticonvulsant properties, occasionally used in pediatric patients for preoperative sedation, deep sedation during mechanical ventilation, and seizure control. Despite its long‐standing clinical use, age‐appropriate dosing remains challenging due to variability across studies and limited ...
Victoria Etges Helfer   +12 more
wiley   +1 more source

Outer Membrane Vesicles Mediate the Secretion and Nuclear Trafficking of a Bacterial Nucleomodulin

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
(A) We propose that Helicobacter pylori secretes a nucleomodulin, Tumour Necrosis Factor‐α‐inducing protein (Tipα), predominantly via extracellular vesicles (EVs), also known as outer membrane vesicles, rather than as free protein. (B) EVs carrying Tipα enter eukaryotic cells by endocytosis and independently of surface‐expressed nucleolin, then traffic
Jack K. Emery   +14 more
wiley   +1 more source

Host Factor Induced Bacterial Extracellular Vesicles Promote Horizontal Gene Transfer in Vibrio cholerae

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
Antimicrobial stressors, that is, bile or mitomycin C, induce enlarged, nucleic acid‐rich bacterial extracellular vesicles in Vibrio cholerae that facilitate horizontal gene transfer in vitro and during intestinal colonisation. The findings provide a detailed comparison of control versus stress‐induced vesicles, identify bile as a host factor shaping ...
Dominik Fleischhacker   +6 more
wiley   +1 more source

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