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Intraventricular Chloramphenicol

Pediatric Neurosurgery, 1978
Very high intraventricular chloramphenicol levels can be obtained if the standard systemic dose is supplemented with a small intraventricular dose. Chloramphenicol sodium succinate can be hydrolyzed to the microbiologically active chloramphenicol in the ventricular fluid.
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Chloramphenicol Interactions

Pediatrics, 1982
In a recent report describing chloramphenicol pharmacokinetics1 it was stated that patients changing from intravenous to oral administration of the antibiotic exhibited prolonged half-life (t½ = 6.5 ± 2.5 [SD] hours) compared with values obtained during intravenous administration ( t½ = 4.0 ± 1.4 [SD] hours).
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Inactivation of Chloramphenicol by Chloramphenicol-Resistant Bacteria

Journal of Pharmaceutical Sciences, 1964
Virtually all (94.5 per cent of 110) chloramphenicol-resistant strains of Sbigella, Escherichia , and Staphylococcus isolated from clinical cases caused significant inactivation of the antibiotic, but none of the 29 resistant pseudomonads did so. None of the 235 clinically isolated sensitive strains, representing five genera, inactivated the drug ...
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Clinical Pharmacokinetics of Chloramphenicol and Chloramphenicol Succinate

Clinical Pharmacokinetics, 1984
In recent years there has been a renewal of interest in chloramphenicol, predominantly because of the emergence of ampicillin-resistant Haemophilus influenzae, the leading cause of bacterial meningitis in infants and children. Three preparations of chloramphenicol are most commonly used in clinical practice: a crystalline powder for oral administration,
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Chloramphenicol

Pediatric Clinics of North America, 1968
D, Ingall, J D, Sherman
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Chloramphenicol

Pediatrics In Review, 1999
M R, Sills, D, Boenning
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Chloramphenicol Acetyltransferases

Annual Review of Biophysics and Biophysical Chemistry, 1989
W V, Shaw, A G, Leslie
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Chloramphenicol toxicity

The Journal of Pediatrics, 1986
J C, Christenson, M I, Marks
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