Results 71 to 80 of about 135,377 (214)

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

The Absence of E. coli Nucleoid‐Associated Protein FIS at Low Temperature Leads to an Adaptation Response That Causes a Shift Towards Genome Compaction in Small Rods

Molecular Microbiology, EarlyView.
Unlike the wild‐type BW25113, the fis null mutant is characterized by biphasic growth at 12°C. During the first phase of growth, the absence of FIS results in the formation of filaments with dispersed nucleoids. During the acclimation phase, the FIS Null Adaptation Response is activated that leads to an increase in cell division and nucleoid ...
Pamela G. Jones
wiley   +1 more source

Structure of chloramphenicol-bound MexB reveals residues in the distal binding pocket that are critical for substrate recognition. [PDF]

J Biochem
Ueda Y, Yonehara R, Ishizaka-Ikeda E, Nakagawa A, Yamashita E.   +4 more
europepmc   +1 more source

Protein STM3547 From Salmonella typhimurium Is a Phosphofructose Kinase B‐Type Enzyme With Ribose Kinase Activity

Molecular Microbiology, EarlyView.
The metabolism of ribose starts with the phosphorylation of its 5′ hydroxyl group. Salmonella typhimurium has two kinases that perform this function, namely ribose rinase (RbsK) and deoxyribose kinase (DeoK). Here we report a new ribose kinase that we named RikA. The illustration was partially created in BioRender.
Regan D. McCormick, Aatif A. Jabbar, Jorge C. Escalante‐Semerena   +2 more
wiley   +1 more source

Potentially Hazardous Drugs in the Paediatric ICU: A Narrative Review on the Exemplary Cases of Propofol, Chloramphenicol, and Acetylsalicylic Acid. [PDF]

Children (Basel)
Beckers L, Verbruggen J, Saldien V, De Dooy J, van Zanten E, Peros T, Wiggelinkhuizen M, Jorens PG.   +7 more
europepmc   +1 more source

Chloramphenicol Misuse [PDF]

Nature, 1970
openaire   +2 more sources

Roles of PknB and CslA in Cell Wall Morphogenesis of Streptomyces

Molecular Microbiology, EarlyView.
Streptomyces grow by extending hyphal tips, a process regulated by polarisome complexes anchored by DivIVA. Using a genetic screen based on toxic DivIVA overproduction, we identified the kinase PknB as a key regulator of cell envelope construction.
Marta Derkacz, Andrew Watson, Akshada Gajbhiye, Michał Tracz, Dagmara Jakimowicz, Matthias Trost, Jeff Errington, Bernhard Kepplinger   +7 more
wiley   +1 more source

4-Hydroxycinnamic acid and Itaconic acid exhibit broad spectrum synergy with conventional antibiotics in inhibiting multidrug-resistant Salmonella Typhimurium. [PDF]

Sci Rep
Phasaludeen B, Sheffield H, Pancholi K, Bharathan G, Darwich DM, Khan H, Mudgil P, Habib I, Huber L, Buhr R, Nazir A, Srikumar S.   +11 more
europepmc   +1 more source

Chain‐Length Regulation by WzzE Is Necessary for, but Genetically Separable From, Cyclic Enterobacterial Common Antigen Synthesis

Molecular Microbiology, EarlyView.
Here, we demonstrate that polysaccharide chain length regulation plays a distinct role in enabling formation of a cyclic molecule important for the bacterial cell surface. However, this function is necessary, but not sufficient for the cyclic molecule's biosynthesis.
Joseph F. Carr, Yohannes H. Rezenom, Jennifer S. Rudolf, Daniel J. Warzecha, Angela M. Mitchell   +4 more
wiley   +1 more source

Rapid Optical Nanomotion-Based Antibiotic Susceptibility Testing of Kombucha-Associated Acetic Acid Bacteria and <i>Escherichia coli</i>. [PDF]

Foods
Moreno Córdoba M, Radonicic V, Kasas S, Willaert RG.   +3 more
europepmc   +1 more source