Results 91 to 100 of about 594 (190)
Smart Molecules, EarlyView.Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu +15 more
wiley +1 more source
Monoalcohol‐Directed Shape Control in a Surfactant‐Free Gold Nanoplate Synthesis
Small Methods, EarlyView.Surfactant‐free monoalcohol syntheses are advantageous in that they yield colloidal nanostructures that are free of persistent shape‐directing agents but at the expense of realizing only spherically‐shaped nanoparticles. In this work, this limitation is overcome using a low‐complexity light‐driven synthetic protocol yielding periodic arrays of gold ...
Brendan D. Nieukirk +7 more
wiley +1 more source
The Chemical Record, EarlyView.Hydrophilic substituents were introduced onto the silicon atoms of random polysilsesquioxanes (PSQs) to improve water permeability and absorptivity for exploring the applications of PSQ materials as heat‐ and chlorine‐resistant water desalination reverse osmosis (RO) membranes and scratch‐resistant antifogging coating materials.
Takashi Hamada +2 more
wiley +1 more source
Decoupling Fe0 Application and Bioaugmentation in Space and Time Enables Microbial Reductive Dechlorination of Trichloroethene to Ethene: Evidence from Soil Columns. [PDF]
Environ Sci Technol, 2023 Mohana Rangan S +7 more
europepmc +1 more source
Avoiding pitfalls when modelling ligands in macromolecular crystallography
Acta Crystallographica Section D, EarlyView.Flawed protein–ligand X‐ray structures can misdirect drug discovery based on PDB‐deposited models. This review uses publicly available PDB examples to highlight potential pitfalls, from absent ligands to incorrect chemistry, and presents a practical validation approach to improve model reliability.The determination of protein–ligand complex structures ...
Oliver S. Smart +4 more
wiley +1 more source
Acidophilic methanotrophs: Occurrence, diversity, and possible bioremediation applications. [PDF]
Environ Microbiol Rep, 2023 Hwangbo M, Shao Y, Hatzinger PB, Chu KH.
europepmc +1 more source
Temporal Evolution of Contaminant Mass Discharge: Effect of Source Remediation at Contaminated Sites
Groundwater Monitoring &Remediation, EarlyView.Abstract Contaminant mass discharge (CMD) is a key metric for evaluating remediation performance at contaminated sites posing a risk to groundwater. This study assesses temporal CMD trends and associated uncertainties using a geostatistical approach at a chlorinated solvent contaminated site following source zone remediation, supported by two decades ...
Anton Bøllingtoft +4 more
wiley +1 more source
Editorial: Organohalide respiration: New findings in metabolic mechanisms and bioremediation applications, Volume II. [PDF]
Front Microbiol, 2022 Wang S, He J, Shen C, Manefield MJ.
europepmc +1 more source
Groundwater Monitoring &Remediation, EarlyView.Abstract At many sites, chlorinated ethenes in some of the monitoring wells remain above cleanup goals, even though the water produced by the pumped wells of the pump‐and‐treat system meets the goals. Regulators and site risk managers need tools to determine whether it is appropriate to shut‐down the pump‐and‐treat system and transition to monitored ...
John T. Wilson +8 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Salt stress and nitrogen utilisation efficiency (NUE) represent critical constraints affecting worldwide crop productivity. While nitrate transporter proteins (NPFs) have been implicated in saline chloride (Cl−) ion transport, the mechanistic linkage between chloride stress and NUE remains poorly understood.
Zeqi Zhao +6 more
wiley +1 more source