Results 121 to 130 of about 125,568 (336)
Advanced Science, EarlyView.This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen +7 more
wiley +1 more source
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2
Nature, 2020 M. Hoffmann +9 more
semanticscholar +1 more source
Advanced Science, EarlyView.Cysteine attracts interest due to its unique electrochemical activity and emerging relationship with disulfidptosis. This study develops a new electrochemical nanosensor, which represents the first of its kind capable of detecting intracellular cysteine for various types of tumor cells and primary tumor cells in mice to evaluate disulfidptosis ...
Congcong Zhang +12 more
wiley +1 more source
Chloroquine and hydroxychloroquine as available weapons to fight COVID-19
International Journal of Antimicrobial Agents, 2020 P. Colson +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen +14 more
wiley +1 more source
Artemether-Lumefantrine Versus Chloroquine for the Treatment of Uncomplicated Plasmodium knowlesi Malaria: An Open-Label Randomized Controlled Trial CAN KNOW [PDF]
, 2017 Matthew J. Grigg +11 more
openalex +1 more source
Advanced NanoBiomed Research, EarlyView.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
"THE EFFECT OF CHLOROQUINE ON THE INFECTIVITY OF RODENT MALARIA PARASITES TO ANOPHELES STEPHENSI " [PDF]
Iranian Journal of Public Health, 1977 There was a statistically significant difference in the number of oocysts, developed in Anopheles stephensi which had fed on mice infected with chloroquine resistant strains (NY 151./2B and. P.y.
A.N., Hamidi
doaj