Results 271 to 280 of about 125,568 (336)

Searching for Novel Antiviral Agents as COVID19 Treatments: Guanidino Diaryl Thioureas

ChemMedChem, Volume 21, Issue 1, January 2026.
Structure of the "hit‐compound" found and the proposed interaction with the active site of the TMPRSS2 protease, involving a reversible mechanism of action, are shown. The COVID‐19 pandemic highlighted the urgent need for effective antiviral treatments targeting SARS‐CoV‐2.
Marco Minneci, Barbara Farkaš, Adeyemi Rahman, Amy Kempf, Inga Nehlmeier, Stefan Pöhlmann, Isabel Rozas   +6 more
wiley   +1 more source

Issues associated with malaria self-medication in sub-Saharan Africa: A systematic literature review and meta-analysis. [PDF]

Malariaworld J
Amaka JI, MacLeod E, Picozzi K, Fyfe J, Ezenyi IC, Ijaiya IS, Attah DD, Godwin BA, Obisike VU, Galamaji MM.   +9 more
europepmc   +1 more source

Cholesterol Deficiency Directs Autophagy‐Dependent Secretion of Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Inhibition of cholesterol biosynthesis within models of rare disease and cancer causes increased release of small extracellular vesicles (sEVs) with distinct biological properties. Mechanistically, cholesterol depletion leads to impaired autophagic flux, redirection of autophagosomes to late endosomes, and subsequently increased sEV secretion ...
Jazmine D. W. Yaeger, Sonali Sengupta, Austin L. Walz, Mayu Morita, Terry K. Morgan, Paola D. Vermeer, Kevin R. Francis   +6 more
wiley   +1 more source

Design, Synthesis, and Antimalarial Evaluation of New Spiroacridine Derivatives. [PDF]

Antibiotics (Basel)
Cavalcanti MAT, Albino SL, Menezes KJDS, de Araújo WJS, Campos FFGR, Dos Reis MML, Morais I, Duarte DMFA, Nascimento IJDS, Rodrigues-Junior VDS, Nogueira F, Moura RO.   +11 more
europepmc   +1 more source

Oral Melatonin in Critically Ill Patients With COVID‐19: A Quasi‐Experimental Pragmatic Trial

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Melatonin has demonstrated antioxidant, anti‐inflammatory, and potential antiviral properties. Its therapeutic role in critically ill COVID‐19 patients admitted to intensive care was underexplored at the start of the pandemic. We conducted a quasi‐experimental, pragmatic study over 4 consecutive uninterrupted time periods alternating control ...
Miguel Sánchez‐García, Jesús A.F. Tresguerres, Manuel Álvarez‐González, Belén de la Hera, Virginia Puebla, Lidia Ybañez, José‐Manuel Martínez‐Sesmero, Antonio Blesa, Juan‐Carlos Martín‐Benítez, Fernando Martínez‐Sagasti, Paloma González‐Arenas, Sara Domingo, Cándido Pardo, Silmary Maichle, Carolina Postigo, Sara De‐Miguel, María Bringas, Raquel González‐Casanova, Viktor Yordanov, Alberto Delgado‐Iribarren, Esther Culebras, Miguel A. Armengol‐de la‐Hoz, Antonio Núñez‐Reiz   +22 more
wiley   +1 more source

Marked platelet transfusion refractoriness caused by anti-HLA-I and anti-HPA-5b antibodies: A case report. [PDF]

Medicine (Baltimore)
Wang Y, Liu Z, Duan S, Lin C, Jin Y, Wang H, Wang Y, Tang L, Wang M.   +8 more
europepmc   +1 more source

Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways

MedComm, Volume 7, Issue 1, January 2026.
Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. It restores synaptic function impaired by Aβ toxicity and improves cognitive performance in AD mouse models, APP/PS1 and 3xTg‐AD.
Yongeun Cho, Jeongmi Lee, Bo Youn Choi, Jin‐Ho Yun, Sukmin Han, Seung Hyun Baek, Jinsu Park, Yoonsuk Cho, Hark Kyun Kim, Eunae Kim, Leon F. Palomera, Jeein Lim, Yeji Jeon, Jeonghyeong Im, Ju‐Mi Hong, Tai Kyoung Kim, Sung Hyun Kim, Joung Han Yim, Dong‐Gyu Jo   +18 more
wiley   +1 more source

Benzilmonoximethiocarbohydrazide Schiff bases as multifunctional antimalarial and antioxidant scaffolds: synthesis, biological evaluation, and mechanistic insights. [PDF]

RSC Adv
Singh SK, Bagul A, Kumar M, Tufail A, Kulkarni SW, Sharma S, Dubey A.   +6 more
europepmc   +1 more source

Obestatin Treatment Counteracts Muscle Wasting by Reactivation of Autophagy in Duchenne Muscular Dystrophy

MedComm, Volume 7, Issue 1, January 2026.
Obestatin signaling reactivates autophagy by NEDD4‐L activation under DMD conditions. Tyrosine switch on NEDD4‐L activates autoubiquitination that serves as a scaffold to recruit USP10 to form a deubiquitination complex, which stabilizes VPS34 to promote autophagy by activation of the Beclin1 complex. In parallel, NEDD4‐L favors AMPK exposure to CaMKKß
Icía Santos‐Zas, Silvia Costas‐Abalde, Andrea C. Lodeiro, Fátima Fernández‐Barreiro, Tania Cid‐Díaz, Saúl Leal‐López, Jessica González‐Sánchez, Mar García‐Lamela, Lucía Debasa‐Corral, Carlos S. Mosteiro, Kamel Mamchaoui, Vincent Mouly, Xesús Casabiell, Rosalía Gallego, José Luis Relova, Yolanda Pazos, Jesus P. Camiña   +16 more
wiley   +1 more source

From Forestry By-Product to Functional Food Ingredient Innovation: Antiproliferative, Antimetastatic and Antiplasmodial Activities of Norway Spruce Sawdust Extract. [PDF]

Foods
Carvalho Cardoso Consentini J, Furlaneto G, Alves Bento N, Caputo Silva T, Vitor Vieira F, Kilpelainen P, Paiva da Silva GK, Bofill Verdaguer I, Crispim M, Dos Santos Lima A, Azevedo L.   +10 more
europepmc   +1 more source