Results 191 to 200 of about 5,666 (226)

Chlorothiazid in Diabetes Insipidus

Nature, 1959
LARAGH and his co-workers1 have demonstrated that chlorothiazid administered to normal subjects in the midst of a sustained water diuresis provokes a flow of urine of substantially higher concentration for a given rate of total osmolar output than urine formed by water-loaded subjects to whom meralluride is given.
J. D. Crawford, G. C. Kennedy
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TREATMENT OF HYPERTENSION WITH CHLOROTHIAZIDE

Journal of the American Medical Association, 1959
When chlorothiazide is used, lower and, hence, less toxic dosages of other hypertensive agents become effective in controlling blood pressure. Chlorothiazide does not reduce blood pressure in normotensive subjects, although the drug induces the same increase in salt excretion. Regarding the mechanism of antihypertensive effect of chlorothiazide, it may
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CHLOROTHIAZIDE IN HYPERTENSIVE AND NORMOTENSIVE PATIENTS

Annals of the New York Academy of Sciences, 1958
This was one of Freis's first attempts to evaluate chlorothiazide, a new diuretic that acted to increase the excretion of water and salt, and therefore reduced fluid in blood volume and decreased blood pressure. Here, along with several colleagues from the Veterans Administration and Georgetown University, he recognized the promise that this ...
Alvin E. Parrish, Annemarie Wanko, Ilse M. Wilson, Edward D. Freis   +3 more
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Bioavailability of Chlorothiazide Tablets in Humans

Journal of Pharmaceutical Sciences, 1979
A urinary excretion bioavailability study was conducted in 12 healthy male subjects to evaluate three 250-mg and three 500-mg chlorothiazide tablet products. The study was a crossover design, and urine samples were collected 1, 2, 3, 4, 6, 8, 12, and 24 hr after administration of each dose. The resulting data were statistically analyzed for significant
Armen P. Melikian, Marvin C. Meyer, Arthur B. Straughn   +2 more
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The binding of chlorothiazide to plasma proteins

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1971
Abstract Association constants and values for the enthalpy and entropy of binding of chlorothiazide to human serum albumin have been determined by a variety of methods. The influence of chlorothiazide binding on the plasma levels of the hypotensive drug pempidine has been considered.
A. Rosen, A. Breckenridge
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PURPURA DUE TO CHLOROTHIAZIDE (DIURIL)

Journal of the American Medical Association, 1958
Chlorothiazide (Diuril) is an orally administered, nonmercurial, diuretic agent. Chemically, it is known as 6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide. 1 It was made available commercially only this year; but, in its use thus far reported, the absence of toxic and otherwise undesirable side-effects has been especially noted.
Manuel O. Jaffe, Robert R. Kierland
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Photosensitivity Due to Chlorothiazide and Hydrochlorothiazide

New England Journal of Medicine, 1959
CHLOROTHIAZIDE and hydrochlorothiazide are aromatic sulfonamides differing from each other only in that in the hydrochlorothiazide the 3, 4 carbon-nitrogen bond is saturated by 2 hydrogen atoms whe...
Leonard C. Harber, Rudolf L. Baer, Alvin M. Lashinsky   +2 more
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Polythiazide and Chlorothiazide

JAMA: The Journal of the American Medical Association, 1963
To the Editor: —The editorial, "Clinical Evaluation of New Drugs" (184:233 [April 20] 1963), and the article by Dr. Spiekerman and his colleagues in the same issue ofThe Journal(p 191) were read with interest. I am surprised that more attention was not devoted to the duration of action of chlorothiazide as compared with polythiazide, since this is ...
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Mechanism of the Phosphaturia due to Chlorothiazide

1980
CTZ caused a phosphaturia when baseline phosphate excretion was not already high. Furthermore, when th influence of PTH is withdrawn, the excretion of phosphate appears to be largely affected by changes in urinary pH.
P. Teredesai, Joseph Winaver, Jules B. Puschett   +2 more
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Clinical pharmacology of chlorothiazide compounds

Clinical Pharmacology & Therapeutics, 1962
The chlorothiazide compounds are effective, safe diuretics. They are as potent when administered by mouth as when given parenterally. They augment the excretion of water, salt, and to a lesser extent K+ and HCO3‐ ions. They combine the saluretic action of the organic mercurials with the carbonic anhydrase inhibitory action of sulfonamyl compounds.
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