Results 1 to 10 of about 292 (97)

Extinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases [PDF]

Molecular Medicine
Background NLRP3 inflammasome immoderate activation results in the occurrence of various inflammatory diseases, but the clinic medications targeting NLRP3 inflammasome are still not available currently.
Zhilei Wang, Jingwen Liu, Yu Mou, Yuchen Li, Wenhao Liao, Menglin Yao, Ting Wang, Hongping Shen, Qin Sun, Jianyuan Tang   +9 more
doaj   +5 more sources

Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase [PDF]

ACS Central Science
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited treatment options. Thus, it is essential to investigate potential druggable targets to improve IPF treatment outcomes. By screening a curated library of 201 small
Xiangyu Yang, Geng Lin, Yitong Chen, Xueping Lei, Yitao Ou, Yuyun Yan, Ruiwen Wu, Jie Yang, Yiming Luo, Lixin Zhao, Xiuxiu Zhang, Zhongjin Yang, Aiping Qin, Ping Sun, Xi-Yong Yu, Wenhui Hu   +15 more
doaj   +5 more sources

Chlorquinaldol, a topical agent for skin and wound infections: anti-biofilm activity and biofilm-related antimicrobial cross-resistance [PDF]

Infection and Drug Resistance, 2019
Alessandro Bidossi,1 Marta Bottagisio,1 Roberta De Grandi,1 Lorenzo Drago,2 Elena De Vecchi11Laboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy; 2Laboratory of Clinical Microbiology, Department of ...
Bidossi A, Bottagisio M, De Grandi R, Drago L, De Vecchi E   +4 more
doaj   +5 more sources

In vitro Antimicrobial Activity of Chlorquinaldol against Microorganisms Responsible for Skin and Soft Tissue Infections: Comparative Evaluation with Gentamicin and Fusidic Acid [PDF]

Frontiers in Microbiology, 2017
Skin and soft tissue infections (SSTIs) are a major therapeutic challenge for clinicians. The emergence of pathogens with decreased susceptibility to available therapies has become an emerging problem often associated with treatment failure. Hence, there
Monica Bortolin, Alessandro Bidossi, Elena De Vecchi, Maura Avveniente, Lorenzo Drago, Lorenzo Drago   +5 more
doaj   +7 more sources

Insight into the Mode of Action of 8-Hydroxyquinoline-Based Blockers on the Histamine Receptor 2 [PDF]

Biosensors, 2023
Histamine receptor 2 (HRH2) blockers are used to treat peptic ulcers and gastric reflux. Chlorquinaldol and chloroxine, which contain an 8-hydroxyquinoline (8HQ) core, have recently been identified as blocking HRH2.
Amisha Patel, Paola L. Marquez-Gomez, Lily R. Torp, Lily Gao, Pamela Peralta-Yahya   +4 more
doaj   +2 more sources

GSH-Responsive Nano-Photosensitizer for Potentiating Photodynamic Therapy Through Multi-Pronged Synergistic Upregulation of Ferroptosis Sensitivity [PDF]

Antioxidants
Impeded by the limited light penetration of photodynamic therapy (PDT) to tissues and the hypoxic environment of solid tumors, the clinical therapeutic efficacy and application are below expectations.
Yunong Ma, Kexin Xu, Jing Feng, Xi Zhao, Peilin Tian, Jiayang Luo, Luyao Xu, Jiaxing Song, Cuixia Lu   +8 more
doaj   +2 more sources

Identification of Agents Active against Methicillin-Resistant Staphylococcus aureus USA300 from a Clinical Compound Library [PDF]

Pathogens, 2017
Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat for effective treatment of several difficult-to-treat infections in humans.
Hongxia Niu, Rebecca Yee, Peng Cui, Lili Tian, Shuo Zhang, Wanliang Shi, David Sullivan, Bingdong Zhu, Wenhong Zhang, Ying Zhang   +9 more
doaj   +2 more sources

Perilla frutescens seeds enhance lamb immunity and antioxidant capacity via the microbiota-gut-liver-muscle axis [PDF]

Journal of Animal Science and Biotechnology
Background Perilla frutescens seeds (PFS) are gaining recognition as a natural alternative to antibiotics in livestock, supporting sustainable farming and animal health. However, the underlying molecular mechanisms through which PFS influence host immune
Yue Yu, Boyan Zhang, Xianzhe Jiang, Yimeng Cui, Yuqing Shang, Yanqin Jin, Tiancheng Sun, Ziwei Yuan, Zihan Zhang, Hailing Luo, Sokratis Stergiadis, Bing Wang   +11 more
doaj   +2 more sources

Vaginal foreign body mimicking cervical cancer in postmenopausal woman – case study [PDF]

Menopause Review, 2015
We present a case report of a 73-year-old, postmenopausal woman with detailed history of breast cancer and oncology treatment including tamoxifen therapy. She presented at the clinic of gynecology and obstetrics with recurrent inflammation of the urinary
Michał Ciebiera, Aneta Słabuszewska-Jóźwiak, Witold Ledowicz, Grzegorz Jakiel   +3 more
doaj   +2 more sources

Chlorquinaldol targets the β-catenin and T-cell factor 4 complex and exerts anti-colorectal cancer activity.

Pharmacological Research, 2020
Aberrant activation of Wnt signaling plays a critical role in the initiation and progression of colorectal cancer (CRC). Chlorquinaldol (CQD) is a topical antimicrobial agent used to treat skin infections. Little is known about the anticancer activity of
Ling Wang, K. Deng, L. Gong, Liang Zhou, Sapna Sayed, Huan Li, Qi Sun, Zi-jie Su, Zhongyuan Wang, Shanshan Liu, Huifang Zhu, Jiaxing Song, D. Lu   +12 more
semanticscholar   +3 more sources