Results 151 to 160 of about 228,451 (311)
Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy
Advanced Science, EarlyView.Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee +11 more
wiley +1 more source
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, EarlyView.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
Биопрепараты: Профилактика, диагностика, лечение, 2018 Perfusion cultivation process for CHO cells producing recombinant B-domen deleted coagulation factor VIII was developed. Cell culture medium and feed supplement were optimized by screening of big panel of prototype media and supplements.
A. N. Morozov +4 more
doaj
Advanced Science, EarlyView.We used a zinc oxide–carbon composite interlayer (ZnO@C) via the electron‐beam (e‐beam) irradiation method to fabricate a cost‐effective, high‐energy‐density, anode‐free solid‐state battery. Chemical anchoring between the ZnO and carbon enabled uniform nanoscale morphology, mitigating the high surface energy of the ZnO NPs.
Joonhyeok Park +16 more
wiley +1 more source
Advanced Science, EarlyView.A CCM‐based architectural strategy is introduced for high‐temperature PEM fuel cells, enabling MPL‐free carbon paper gas diffusion layers via decal‐transfer processing. By co‐engineering the CCM, GDL, and a G‐foam flow field, oxygen transport is enhanced while phosphoric‐acid leakage is suppressed, resulting in high power density and stable operation ...
Seongmin Cho +6 more
wiley +1 more source
Zero Thermal Expansion and Local Structure in KxMnxFe2‐xMo3O12‐Based Materials
Advanced Science, EarlyView.Local structure engineering via ion insertion drives local structural transformation from low‐symmetry P21/a to high‐symmetry R‐3c, enhancing structural flexibility and realizing a transition from positive thermal expansion to wide‐temperature‐range zero thermal expansion in KxMnxFe2‐xMo3O12‐based materials.
Gongsen He +13 more
wiley +1 more source
Advanced Science, EarlyView.Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole +17 more
wiley +1 more source
Hyperosmolality on protein glycosylation in CHO cells [PDF]
Biotechnology and Bioengineering, 2017 openaire +2 more sources
Advanced Science, EarlyView.A Cu‐mediated Ni(OH)2 catalyst with orthogonal activity by precise valence engineering simultaneously accelerates rate‐determining aldehyde C─H activation in HMF oxidation and impedes O─H deprotonation in competing OER. This multi‐functional synergistic catalysis enables FDCA production at industrial‐level current densities without sacrificing FEFDCA ...
Junge Yang +7 more
wiley +1 more source
Advanced Science, EarlyView.Jin et al. developed IEICO‐F nanoparticles with enhanced photothermal conversion efficiency via optimized push‐pull effect. Under 808 nm laser, these nanoparticles effectively generated heat to kill osteosarcoma cells and exhibited significant tumor suppression in vivo. Therefore, this novel A‐D‐A type molecule‐based photothermal therapy strategy holds
Zhijian Jin +9 more
wiley +1 more source