Results 351 to 360 of about 11,449,307 (399)
A hierarchical structure in the N-glycosylation process governs the N-glycosylation output: prolonged cultivation induces glycoenzymes expression variations that are reflected in the cellular N-glycome but not in the protein and site-specific glycoprofile of CHO cells. [PDF]
GlycobiologyArigoni-Affolter I +4 more
europepmc +1 more source
Prevalence of Cystic Fibrosis Carrier Status in Chronic Rhinosinusitis Without Nasal Polyp
International Forum of Allergy &Rhinology, EarlyView.
Do‐Yeon Cho +4 more
wiley +1 more source
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Journal of Biotechnology, 2017
Chinese hamster ovary (CHO) cells account for the production of the majority of biopharmaceutical molecules - however, the molecular basis for their versatile properties is not entirely understood yet and the underlying cellular processes need to be characterized in detail.
Wippermann, Anna, Noll, Thomas
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Chinese hamster ovary (CHO) cells account for the production of the majority of biopharmaceutical molecules - however, the molecular basis for their versatile properties is not entirely understood yet and the underlying cellular processes need to be characterized in detail.
Wippermann, Anna, Noll, Thomas
openaire +3 more sources
Glycoengineering of CHO Cells to Improve Product Quality
Methods in molecular biology, 2017Chinese hamster ovary (CHO) cells represent the predominant platform in biopharmaceutical industry for the production of recombinant biotherapeutic proteins, especially glycoproteins. These glycoproteins include oligosaccharide or glycan attachments that represent one of the principal components dictating product quality. Especially important are the N-
Michael J. Betenbaugh +3 more
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Current Drug Discovery Technologies, 2020
Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used ...
S. Sharker, Atiqur Rahman
semanticscholar +1 more source
Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used ...
S. Sharker, Atiqur Rahman
semanticscholar +1 more source
Chromosome stability in CHO cells
Somatic Cell Genetics, 1977The established cell line derived many years ago from Chinese hamster ovary (CHO cells) has been studied for the extent of chromosomal variation. Because this cell line is used extensively for genetic studies, the contribution of chromosome variability to genetic variability has also been examined. The quasidiploid CHO cells were found to have a banded
Chin Chin Ho +2 more
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Biotechnology progress (Print), 2018
The culture of Chinese Hamster Ovary (CHO) cells for modern industrial applications, such as expression of recombinant proteins, requires media that support growth and production.
Frank V Ritacco +2 more
semanticscholar +1 more source
The culture of Chinese Hamster Ovary (CHO) cells for modern industrial applications, such as expression of recombinant proteins, requires media that support growth and production.
Frank V Ritacco +2 more
semanticscholar +1 more source
Dynamic model of CHO cell metabolism
Metabolic Engineering, 2011Fed-batch cultures are extensively used for the production of therapeutic proteins. However, process optimization is hampered by lack of quantitative models of mammalian cellular metabolism in these cultures. This paper presents a new kinetic model of CHO cell metabolism and a novel framework for simulating the dynamics of metabolic and biosynthetic ...
Kyongbum Lee, Ryan P. Nolan
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A CHO-cell mutant with a defect in cytokinesis
Somatic Cell Genetics, 1976In a selection procedure designed to enrich for temperature-sensitive mutant cells blocked in mitosis a CHO-cell mutant was isolated which has a defect in cytokinesis as the basis of its temperature-sensitive phenotype. Cultures of the mutant had an abnormally high percentage (ie.
Patricia A. Lindl +3 more
openaire +3 more sources