Results 91 to 100 of about 2,199,001 (304)
Behavioral Biases in Annuity Choice: An Experiment [PDF]
We conduct a neutral-context laboratory experiment to systematically investigate the role of the hit-by-bus concern in explaining the annuitization puzzle: the low rate of retirement-asset annuitization relative to the predictions of standard models.
Lina Walker, Robert S. Gazzale
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
HYPOTHETICAL (NON)BIAS IN CHOICE EXPERIMENTS: EVIDENCE FROM FRESHWATER PRAWNS [PDF]
A mail survey choice experiment and in-store controlled experiment were conducted concurrently in the same location to test for hypothetical bias in choice experiments using a new product—freshwater prawns.
Darren Hudson +2 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Resources, 2018 Alpine mountains represent one of the most important tourist destinations in the world, constituting approximately 3.1% of the global tourism market when considering the tourist flows coming from abroad.
Tiziano Tempesta, Daniel Vecchiato
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Snack preferences among school-aged children: evidence from discrete choice experiments
BMC Public HealthBackground Accelerated economic development and innovative food industry trends have contributed to worsening dietary imbalanced among Chinese school-aged population.
Hanyi Li +11 more
doaj +1 more source
City Retailers’ Perceptions of Competition: A Choice Experiment [PDF]
The increase and expansion of out-of-town shopping centres is often criticized for out-competing retail business within city centres. City retailers’ own perceptions of competition within and between retail districts are here analyzed via choice ...
Lang, Åsa
core