Results 201 to 210 of about 1,768,620 (297)

Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish [PDF]

, 2014
A Amsterdam, A Amsterdam, A Bari, A Muto, AB Fernando, Alistair J. Brock, Ari Sudwarts, B Cole, B Cole, BJ Everitt, C Winstanley, Caroline H. Brennan, D Belin, D Economidou, D Economidou, D Michelson, E Rink, E Rink, E Rink, ER Behrend, ES Robinson, F Bymaster, G Golling, G Urcelay, J Dalley, J Holzschuh, J Hosking, J Korf, JA Milstein, L Bizarro, M Bitterman, M Carli, M Lange, M Parker, M Parker, M Parker, M Parker, M Westerfield, Matthew O. Parker, MO Parker, PM Ma, R Navarra, RA Barkley, S Alessi, S Guo, S Guo, S Pliszka, SR Chamberlain, T Darland, T Robbins, T Tay, WT Woodward   +51 more
core   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

A theory of decision-making using diffusion-to-bound models: choice, reaction-time and confidence [PDF]

BMC Neurosci, 2014
Schustek P, Moreno-Bote R.
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Sustained attention is associated with error processing impairment: evidence from mental fatigue study in four-choice reaction time task. [PDF]

PLoS One, 2015
Xiao Y, Ma F, Lv Y, Cai G, Teng P, Xu F, Chen S.   +6 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The effect of sleep deprivation on choice reaction time and anaerobic power of college student athletes. [PDF]

Asian J Sports Med, 2012
Taheri M, Arabameri E.
europepmc   +1 more source