Results 91 to 100 of about 35,855 (199)

Ultrasound for the Detection of Gallbladder Malignancy in Primary Sclerosing Cholangitis

Liver International, Volume 45, Issue 9, September 2025.
ABSTRACT Background and Aims In primary sclerosing cholangitis (PSC), the risk for gallbladder malignancy is increased. Surveillance imaging is used for early diagnosis. The study aims to assess the reliability of ultrasound and magnetic resonance imaging (MRI) for the detection of gallbladder polyps in people with PSC and to define a polyp size as a ...
Johannes Altenmüller, Christiane Wiegard, Marcial Sebode, Ansgar W. Lohse, Christina Villard, Stergios Kechagias, Emma Nilsson, Fredrik Rorsman, Hanns‐Ulrich Marschall, Kalle Jokelainen, Annika Bergquist, Martti Färkkilä, Christoph Schramm   +12 more
wiley   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Volume 20, Issue 16, August 16, 2025.
Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Contribution of Endoscopy in the Diagnosis and Treatment of Patients With Primary Sclerosing Cholangitis

Digestive Endoscopy, EarlyView.
Mamoru Takenaka, Masatoshi Kudo
wiley   +1 more source

Effect of Mild to Moderate Hepatic Impairment on Valemetostat Pharmacokinetics: An Open‐Label, Phase I Study

Clinical Pharmacology in Drug Development, Volume 14, Issue 8, Page 631-641, August 2025.
Abstract Valemetostat tosylate (valemetostat) is a dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1, approved in Japan for the treatment of relapsed/refractory peripheral T‐cell lymphoma and adult T‐cell leukemia/lymphoma. This Phase I, open‐label study evaluated the pharmacokinetics and safety of a single 50‐mg oral dose of valemetostat in
Masaya Tachibana, Thuy Vu Craveiro, Thomas C. Marbury, Samuel Oberstein, George J. Atiee, Ben Tao, Takako Shimizu, Yvonne Lau, Malaz A. Abutarif   +8 more
wiley   +1 more source

Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism

Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.
Loss of intestinal epithelial fucosylation exacerbates alcohol‐related liver injuries. Intestinal epithelial deletion of Fut2 disrupts nicotinamide (NAM) metabolism due to the decline in bacterial nicotinamidase (PncA). Supplemented with pncA overexpressed E.coli to restore gut PncA levels can improve liver damage in alcohol‐induced intestinal ...
Liuying Chen, Zhongwei Yin, Luorui Shang, Hang Yuan, Wenkang Gao, Shuhan Wang, Shuyan Wang, Xiaohua Hou, Shenglan Yang, Huikuan Chu   +9 more
wiley   +1 more source

Intrahepatic bile duct strictures in a liver allograft recipient mimicking recurrent primary sclerosing cholangitis - Follow-up of a case report [PDF]

, 1991
Demetris, AJ, Gordon, R, Hartman, GG, Lerut, J, Starzl, TE   +4 more
core   +1 more source

Current and Emerging Autoantibodies in Ulcerative Colitis

European Journal of Immunology, Volume 55, Issue 8, August 2025.
Autoantibodies in ulcerative colitis target neutrophil and mucosal components, including NETs, goblet cells, and integrins‐offering insight into disease pathophysiology. Understanding these interactions may support biomarker development, enable earlier diagnosis, aid patient stratification, and drive future therapeutic innovation.
Erick A. Mendieta‐Escalante, Klaas Nico Faber, Gerard Dijkstra   +2 more
wiley   +1 more source

Dissecting the Genetic Correlations and Causal Effects of Gut Microbiota on Pan‐Cancer Phenotype: Driven by Common Dietary Preferences

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Cancer is one of the leading causes of death worldwide. Our study indicates that common dietary preferences can influence pan‐cancer risk by driving changes in gut microbiota composition. We recommend that populations at risk of cancer consider appropriate probiotic or dietary interventions.
Yuhang Zhou, Yun Feng, Yue Wang, Yiwen Wang, Xiaolin Liu, Tao Sun, Junnan Xu   +6 more
wiley   +1 more source

Empiric Antibiotic Use With Rescue Infliximab Does Not Improve Outcomes in Acute Severe Ulcerative Colitis: A Retrospective Cohort Study

Health Science Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Background and Aims Antibiotics are sometimes prescribed as concurrent therapy in the management of acute severe ulcerative colitis (ASUC) with a rationale of treating any presumed concurrent infections. It is unclear if there are data indicating any benefit of this clinical practice.
Kofi Clarke, Dominic Amakye, Jiqing Shi, Shannon Dalessio, Kara DiJoseph, Matthew D. Coates   +5 more
wiley   +1 more source

Malignancies Presenting With ANCA Positivity: Two Case Reports and Diagnostic Considerations

Immunity, Inflammation and Disease, Volume 13, Issue 8, August 2025.
ABSTRACT Background ANCA‐associated vasculitides (AAV) are small‐vessel inflammatory disorders characterized by the presence of anti‐neutrophil cytoplasmic antibodies (ANCA), including those against proteinase 3 (PR3) and myeloperoxidase (MPO).
Min Zhao, Yue Lu, Ling Li
wiley   +1 more source