The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease. [PDF]
, 2018 BACKGROUND: Patients with primary sclerosing cholangitis associated with inflammatory bowel disease (PSC-IBD) have a very high risk of developing colorectal neoplasia.
Bao, X +7 more
core +1 more source
Primary sclerosing cholangitis and pregnancy
Clinics and Practice, 2011 Primary sclerosing cholangitis is a progressive disease, and coincidentally in pregnancy it is rare. It is characterized by progressive inflammation and destruction of bile ducts finally resulting in liver failure.
Casper Q. Kammeijer +2 more
doaj +1 more source
Latent class mixed modelling for phenotypic stratification of primary biliary cholangitis patients on first line treatment [PDF]
arXiv, 2022 In patients with primary biliary cholangitis (PBC), the serum liver biochemistry measured during treatment with ursodeoxycholic acid (the UDCA response) accurately predicts long-term outcome. In this study we sought to use liver biochemistry, and in particular alkaline phosphatase (ALP), as a surrogate marker of disease activity, for phenotypic ...
arxiv
Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis [PDF]
, 2011 Background/Aims: The chromosome 4q27 region harboring IL2 and IL21 is an established risk locus for ulcerative colitis (UC) and various other autoimmune diseases.
Albers HM +51 more
core +1 more source
Maximum likelihood estimation of hidden Markov models for continuous longitudinal data with missing responses and dropout [PDF]
arXiv, 2021 We propose an inferential approach for maximum likelihood estimation of the hidden Markov models for continuous responses. We extend to the case of longitudinal observations the finite mixture model of multivariate Gaussian distributions with Missing At Random (MAR) outcomes, also accounting for possible dropout.
arxiv
The incidence of portal vein thrombosis at liver transplantation [PDF]
, 1992 The incidence of portal vein thrombosis was examined in 885 patients who received orthotopic liver transplantations for various end‐stage liver diseases between 1989 and 1990. The thrombosis was classified into four grades.
Iwatsuki, S +3 more
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Deep Generative Survival Analysis: Nonparametric Estimation of Conditional Survival Function [PDF]
arXiv, 2022 We propose a deep generative approach to nonparametric estimation of conditional survival and hazard functions with right-censored data. The key idea of the proposed method is to first learn a conditional generator for the joint conditional distribution of the observed time and censoring indicator given the covariates, and then construct the Kaplan ...
arxiv
Intrahepatic cholangiocarcinoma: review and update [PDF]
, 2018 Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies that could develop at any level from the biliary tree. CCA is currently classified into intrahepatic (iCCA), perihilar and distal on the basis of its anatomical location.
Alvaro, Domenico +7 more
core +1 more source
Comparison of Baseline Covariate Adjustment Methods for Restricted Mean Survival Time [PDF]
arXiv, 2022 The restricted mean survival time is a clinically easy-to-interpret measure that does not require any assumption of proportional hazards. We focus on two ways to directly model the survival time and adjust the covariates. One is to calculate the pseudo-survival time for each subject using leave-one-out, and then perform a model analysis using all ...
arxiv
Journal of Medical Case Reports, 2010 Introduction Although myasthenia gravis is frequently associated with other disorders, it has not been reported together with primary sclerosing cholangitis, complicating the administration of liver-toxic immunosuppressive therapy. Case presentation A 73-
Höflich Sonja, Finsterer Josef
doaj +1 more source