Results 31 to 40 of about 28,815 (254)
Background Diagnostic work-ups in transplanted immunosuppressed patients are a challenge as non-specific findings may be interpreted as transplant-related complications. If the disease in question is rare and slowly developing like pseudomyxoma peritonei
Ebbe Billmann Thorgersen +4 more
doaj +1 more source
Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown etiology. Immunogenetic factors are considered important in its pathogenesis. The genetic susceptibility to primary sclerosing cholangitis is associated, in part, with the HLA HLA-DRB1, DQA1, DQB1 haplotype.
Martins, E, Chapman, R
openaire +6 more sources
Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis [PDF]
Background/Aims: The chromosome 4q27 region harboring IL2 and IL21 is an established risk locus for ulcerative colitis (UC) and various other autoimmune diseases.
Denk, Gerald Ulrich +15 more
core +1 more source
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. [PDF]
TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to
Bergquist Annika +186 more
core +1 more source
Primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease caused by diffuse inflammation and fibrosis that can involve the entire biliary tree. The progressive pathological process obliterates intrahepatic and extrahepatic bile ducts, leading ultimately to biliary cirrhosis, portal hypertension and hepatic failure.
E R, Dickson, N F, LaRusso, R H, Wiesner
openaire +5 more sources
Difficulties in Diagnosing Isolated IgG4-associated Sclerosing Cholangitis
The most common causes of recurrent cholangitis are biliary stones and neoplasia. Primary types of sclerosing cholangitis such as IgG4-associated sclerosing cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) are rare causes of recurrent ...
Gábor Zsóri +3 more
doaj +1 more source
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder characterized by strictures and dilatations of the biliary tree. The median survival has been reported to be 12 years from diagnosis but patients diagnosed during the last decade have been shown to have longer survival of a median of 18 years.
Björnsson, E, Chapman, R
openaire +2 more sources
Primary Sclerosing Cholangitis
Malik S, Dbouk N, Grant LM, Samant H.
europepmc +3 more sources
Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by strictures of the biliary tree complicated by cirrhosis and cholangiocarcinoma. It is immune mediated, although the precise aetiology remains unknown.Research into etiopathogenesis and epidemiology, diagnosis of cholangiocarcinoma, associations with inflammatory ...
Maggs, JR, Chapman, R
openaire +3 more sources
Primary sclerosing cholangitis: a pre-malignant condition [PDF]
Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease with no known cure. It is a serious condition, and diagnosis comes with an increased risk of developing cancer of the gallbladder, bile ducts or liver.
Gerri Mortimore, Mortimore, Gerri
core +1 more source

