Results 91 to 100 of about 50,779 (198)
DEN OpenObjectives Malignant double obstruction, defined as the simultaneous presence of biliary and gastric outlet obstruction, represents a challenging clinical scenario.
Giuseppe Vanella +14 more
doaj +1 more source
Endoscopic small bowel therapies for type 2 diabetes
Nutrition in Clinical Practice, EarlyView.Abstract Type 2 diabetes is a global epidemic despite current medical treatments. Many patients are not responsive to medications, and patients with obesity are hesitant about bariatric surgery. Studies investigating the metabolic effects of Roux‐en‐Y gastric bypass have increasingly demonstrated that the duodenum plays a key role in the ...
Roma Patel +4 more
wiley +1 more source
Portal Hypertension &Cirrhosis, EarlyView.Cirrhosis is frequently accompanied by varying degrees of lipid profile abnormalities. This study confirms that these profiles are differentially affected by disease etiology and progressively worsen—with significant reductions in TC, HDL‐C, and LDL‐C—as liver disease severity increases. TIPS improves lipid profiles, particularly by increasing HDL‐C in
Jiamin Xu +6 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño +4 more
wiley +1 more source
Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2
Rheumatology &Autoimmunity, EarlyView.Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li +5 more
wiley +1 more source
World Journal of Surgery, EarlyView.Biliary anastomotic strictures (BAS) after liver transplant (LT) are a significant contributor to post‐transplant morbidity. Although surgical technique has been proposed as a risk factor, accurate evaluation of technique has been limited by inherent bias in conventional definitions for BAS.
Samith Minu Alwis +7 more
wiley +1 more source
World Journal of Surgery, EarlyView.To describe surgical indications, procedures and outcomes in patients operated for Zollinger‐Ellison syndrome (ZES) in multiple endocrine neoplasia type 1 (MEN1) using a large nationwide cohort. ABSTRACT Objective To describe surgical indications, procedures and outcomes in patients operated for Zollinger‐Ellison syndrome (ZES) in multiple endocrine ...
Sébastien Gaujoux +27 more
wiley +1 more source
When Enzymes Mislead: Assessing the Value of MRCP in Suspected Choledocholithiasis
ANZ Journal of Surgery, EarlyView.ABSTRACT Background The diagnosis of choledocholithiasis (CDL) requires balancing timely intervention against the risks of unnecessary invasive procedures. Although liver function tests (LFTs) are widely used for risk stratification, their static values and short‐term trends remain poorly defined in predicting persistent common bile duct stones.
Renato Pitesa +4 more
wiley +1 more source
Characterisation and Prognostic Implication of Cholestasis After Burn Injury
Alimentary Pharmacology &Therapeutics, EarlyView.In 532 burn ICU patients, we quantified trajectories of cholestasis markers and validated burn‐associated cholestasis definitions. Bilirubin dynamics, particularly hyperbilirubinemia ≥ 2× ULN within 14 days, independently predicted excess in‐hospital and overall mortality beyond burn and critical‐illness severity, identifying a high‐risk subgroup after
Lorenz Semmler +16 more
wiley +1 more source