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New Treatment Paradigms in Primary Biliary Cholangitis.
Clinical Gastroenterology and Hepatology, 2023Primary biliary cholangitis (PBC) is an archetypal autoimmune disease. Chronic lymphocytic cholangitis is associated with interface hepatitis, ductopenia, cholestasis and a progressive biliary fibrosis.
C. Levy, M. Manns, G. Hirschfield
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A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis
New England Journal of Medicine, 2016 Pietro Andreone +2 more
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Lancet, The
Primary biliary cholangitis is a chronic, autoimmune, cholestatic disease that mainly affects women aged 40-70 years. Recent epidemiological studies have shown an increasing incidence worldwide despite geographical heterogeneity and a decrease in the ...
Xiong, John M Vierling
exaly +2 more sources
Primary biliary cholangitis is a chronic, autoimmune, cholestatic disease that mainly affects women aged 40-70 years. Recent epidemiological studies have shown an increasing incidence worldwide despite geographical heterogeneity and a decrease in the ...
Xiong, John M Vierling
exaly +2 more sources
A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis
New England Journal of Medicine, 2018 Background Patients with primary biliary cholangitis who have an inadequate response to therapy with ursodeoxycholic acid are at high risk for disease progression.
Christophe Corpechot +2 more
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World Journal of Surgery, 1984
AbstractComparative study of the clinical features of 125 cases of acute cholangitis revealed that acute obstructive suppurative cholangitis (AOSC, 19 cases) was characterized by leukocytosis, high transaminase levels, bilirubinemia, and a marked thrombocytopenia. Most species of bacilli isolated from the purulent bile were gram‐negative and in 9 of 12
H, Kinoshita +4 more
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AbstractComparative study of the clinical features of 125 cases of acute cholangitis revealed that acute obstructive suppurative cholangitis (AOSC, 19 cases) was characterized by leukocytosis, high transaminase levels, bilirubinemia, and a marked thrombocytopenia. Most species of bacilli isolated from the purulent bile were gram‐negative and in 9 of 12
H, Kinoshita +4 more
openaire +2 more sources
Gut, 2021
Objective Multiple clinical similarities exist between IgG4-related sclerosing cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC), and while gut dysbiosis has been extensively studied in PSC, the role of the gut microbiota in IgG4-SC remains ...
Qiaoyan Liu +22 more
semanticscholar +1 more source
Objective Multiple clinical similarities exist between IgG4-related sclerosing cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC), and while gut dysbiosis has been extensively studied in PSC, the role of the gut microbiota in IgG4-SC remains ...
Qiaoyan Liu +22 more
semanticscholar +1 more source
Primary sclerosing cholangitis
Lancet, The, 2018Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterised by intrahepatic or extrahepatic stricturing, or both, with bile duct fibrosis.
Jessica K Dyson +2 more
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Journal of Pediatric Surgery, 1986
Oriental cholangitis is a progressive hepatic disease characterized by episodic biliary obstruction and sepsis. This is the report of a case of Oriental cholangitis in a nine-year-old girl. Oriental cholangitis should be considered in the differential diagnosis of upper abdominal pain in the susceptible population.
K S, Bergman, B H, Harris
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Oriental cholangitis is a progressive hepatic disease characterized by episodic biliary obstruction and sepsis. This is the report of a case of Oriental cholangitis in a nine-year-old girl. Oriental cholangitis should be considered in the differential diagnosis of upper abdominal pain in the susceptible population.
K S, Bergman, B H, Harris
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A Phase 3 Trial of Seladelpar in Primary Biliary Cholangitis.
New England Journal of MedicineBACKGROUND Effective treatments for patients with primary biliary cholangitis are limited. Seladelpar, a peroxisome proliferator-activated receptor delta agonist, has potential benefits.
G. Hirschfield +22 more
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Baillière's Clinical Gastroenterology, 1997
Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disease whose aetiopathogenesis is unknown. PSC is frequently associated with inflammatory bowel disease, in particular chronic ulcerative colitis, is most commonly observed in young males and is clinically characterized by fatigue, pruritus and jaundice.
P J, Marotta, N F, LaRusso, R H, Wiesner
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Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disease whose aetiopathogenesis is unknown. PSC is frequently associated with inflammatory bowel disease, in particular chronic ulcerative colitis, is most commonly observed in young males and is clinically characterized by fatigue, pruritus and jaundice.
P J, Marotta, N F, LaRusso, R H, Wiesner
openaire +2 more sources