Results 1 to 10 of about 94,453 (216)
Ductular Reaction Underlies Development of Portal Hypertension in Biliary Atresia. [PDF]
Liver IntABSTRACT Background & Aims As better understanding of pathophysiology and reliable predictors for portal hypertension (PH) are needed, we investigated how histological ductular reaction (DR) and liver fibrosis predict PH in biliary atresia (BA). Methods 60 BA patients treated between 1987 and 2024 at Helsinki University Hospital were enrolled. Patients
Luokkala P +4 more
europepmc +2 more sources
Effects of post-hepatic portoenterostomy adjuvant therapy on liver transplantation in children with biliary atresia: A systematic review. [PDF]
JPGN RepAbstract Objectives Biliary atresia (BA) is a cholangiopathy characterized by obstruction of the intrahepatic and extrahepatic bile ducts. Hepatic portoenterostomy (HPE) is the primary palliative treatment and there is still an urgent need to improve post‐HPE management.
de Almeida Silva BF +7 more
europepmc +2 more sources
Maternal risk factors for biliary atresia in neonates: a systematic review and meta-analysis [PDF]
Frontiers in PediatricsObjectiveThe risk factors for neonatal biliary atresia remain unclear. This study aimed to systematically analyze maternal risk factors associated with the development of neonatal biliary atresia (BA).MethodsA systematic search was conducted in PubMed ...
Ke Zhang, Zhu Chen
doaj +2 more sources
JHEP Reports, 2023 Background & Aims: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare liver disease caused by biallelic variations in ABCB4. Data reporting on the impact of genotype and of response to ursodeoxycholic acid (UDCA) therapy on long ...
Emmanuel Gonzales +18 more
doaj +1 more source
Diagnostics, 2021 Biliary atresia is an aggressive liver disease of infancy and can cause death without timely surgical intervention. Early diagnosis of biliary atresia is critical to the recovery of bile drainage and long-term transplant-free survival.
Wenying Zhou, Luyao Zhou
doaj +1 more source
Genetic Factors and Their Role in the Pathogenesis of Biliary Atresia
Frontiers in Pediatrics, 2022 Biliary Atresia, a common basis for neonatal cholestasis and primary indication for Liver Transplantation, accounts for 60% of pediatric Liver Transplantations.
Li-Na Wu +7 more
doaj +1 more source
Hepatology, EarlyView., 2022 Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel +93 more
wiley +1 more source
Clinical Case Reports, 2023 Key Clinical Message A newborn with a rare form of biliary atresia had posterior fossa bleed and subarachnoid hemorrhage despite vitamin K prophylaxis, indicating biliary atresia is a causality rather than chance.
Susmin Karki +5 more
doaj +1 more source
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Hepatology, EarlyView., 2022 Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr +19 more
wiley +1 more source
Annals of Hepatology, 2021 Introduction and objectives: Differentiating biliary atresia from other causes of neonatal cholestasis is challenging, particularly when cytomegalovirus (CMV) and biliary atresia occur simultaneously.
Dongying Zhao +6 more
doaj +1 more source